ANTIHYPERURICEMIA SCREENING OF Mimosa pudica L. HERB EXTRACT THROUGH ITS ANALGESICS AND ANTIINFLAMMATORY ACTIVITY ASSAY

Abstrak

Traditionally, herbs of Mimosa pudica L. are being used
to treat insomnia, hematuria, inflammation, emesis,
dismenorrhoea, menorrhagia, arthritis rhematoid, convultion,
depresion, and diabetes. Previous in vitro study
showed that herbs extract of Mimosa pudica L inhibited
uric acid formation via xanthine oxidase inhibition of
82.11 and 62.10% for concentration of 125 and 62.5 μg/
mL, respectively. Hyperuricemia is indicated by pain and
oedema which are the symptoms of inflammation. This in
vivo study was perfor-med to screen antihyperuricemia
activity of herbs extract of Mimosa pudica L through
analgesic and antiinflammatory assays on mice.
Analgesic activity of Mimosa pudica L herb extract at
dosage of 125, 250 and 500 mg/kg of body weight was
observed on mice using writhing reflex method with
acetic acid 0,07 % as inducer. The results showed that
all three dosages inhibited pain at the percentage of
9.58, 45.35, and 60.28% respectively. Antiinflammatory
activity assay was done using carageenan-induced paw
edema method on white male rats. Dosages used were
250, 500 and 1000 mg/kg of body weight. The results
showed that all three dosages inhibited edema at the
percentages of 35.20, 42.74, and 51.10% respectively. It is
concluded that herbs extract of Mimosa pudica L can be
proposed as an antihyperuricemia.
Keywords: Antihyperuricemia, Analgesic, Anti-inflammatory,
Mimosa pudica L.