Hypoglycemic Effect of Aquatic Extract of Stevia in Pancreas of Diabetic Rats: PPARγ – Dependent Regulation or Antioxidant Potential: Review

Abdurahman Ridho, Ellin Febrina

Abstrak


Obat tradisional dengan efek antidiabetes dianggap cocok untuk mengobati diabetes. Di antara tanaman-tanaman herbal, Stevia rebaudiana (Bert.) terkenal karena rasa manis dan efek yang menguntungkan dalam pengaturan glukosa. Namun, sedikit yang diketahui tentang mekanisme yang tepat dari stevia di jaringan pankreas. Oleh karena itu, studi ini meneliti efek yang mungkin dari stevia pada pankreas dalam mengontrol hiperglikemia yang dilihat dengan metode uji toleransi glukosa, induksi streptozotocin, dan aloksan menggunakan tikus Sprague-Dawley dan tikus Wistar. Banyak penelitian yang menyatakan bahwa stevia bekerja pada jaringan pankreas untuk meningkatkan kadar insulin dan memberikan efek hipoglikemia yang menguntungkan melalui mekanisme yang tergantung PPARγ dan sifat antioksidan stevia.

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DOI: https://doi.org/10.24198/jf.v14i3.10580

DOI (PDF): https://doi.org/10.24198/jf.v14i3.10580.g5062

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