SELULOSA MIKROKRISTAL : ISOLASI, KARAKTERISASI, DAN APLIKASI DALAM BIDANG FARMASETIK

Ina Widia, Nasrul Wathoni

Abstrak


Selulosa mikrokristal merupakan selulosa murni yang diisolasi dari alfa selulosa. Selulosa mikrokristal dapat diisolasi dari beberapa sumber alam seperti tanaman berkayu, kulit kapas, jerami, ampas tebu dengan tahapan delignifikasi menggunakan larutan basa, bleaching, dan hidrolisis α-selulosa dengan menggunakan larutan asam encer pada suhu  tinggi. Karakterisasi selulosa mikrokristal dapat dilakukan melalui uji organoleptik, analisis kualitatif, uji pati, kelarutan, susut pengeringan, pH, daya alir dan sudut diam, kompresibilitas, serta dengan menggunakan instrumen Fourier Transform Infrared (FTIR), Scanning Electron Microscope Energy-Dispersive X-ray Spectrofotometry (SEM-EDS), dan Difraktometer sinar-x.  Aplikasi selulosa mikrokristal dalam bidang farmasetik dapat digunakan sebagai pengisi tablet untuk metode kempa langsung, selain itu dapat berfungsi juga sebagai pengikat, penghancur tablet, mempercepat sistem penyampaian obat, dan pembawa padat yang tidak larut air.

Kata kunci : selulosa mikrokristal, isolasi, karakterisasi, aplikasi dalam bidang farmasetik.


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Referensi


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DOI: https://doi.org/10.24198/jf.v15i2.13068

DOI (PDF): https://doi.org/10.24198/jf.v15i2.13068.g6026

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