AKTIVITAS ANTIPROLIFERASI SENYAWA KALKON DARI DAUN JAMBU AIR (Eugenia aquea Burm f.) TERHADAP SEL KANKER PROSTAT DU145

Abstrak

ABSTRAK

Senyawa kalkon telah dilaporkan memiliki aktivitas farmakologis terhadap beberapa sel kanker, diantaranya adalah terhadap sel kanker ovarium (Qi et al., 2014), hati (SMMC-7721) (Ye et.al., 2004), HeLa (Zi et.al., 2005) dan payudara MCF-7 (Subarnas et al., 2012) .

Telah dilakukan uji aktivitas penghambatan senyawa kalkon 2',4'‑dihydroxy‑6‑methoxy‑3,5‑dimethyl­chalcone dari daun jambu air Eugenia aquea Burm f. terhadap sel kanker prostat DU145 dengan pengamatan profil pertumbuhan sel menggunakan metoda MTS assay. Hasil uji MTS menghasilkan nilai IC₅₀  pada pengamatan 24 jam adalah sebesar 7,47 μg/mL dan pada pengamatan 48 jam sebesar 5,84 μg/mL.

ABSTRACT

Chalcone has been reported that it has pharmacology activity towards cancer cells, one of them is ovarium (Qi et al., 2014), liver (SMMC-7721), HeLa (Zi et.al., 2005), and breast cancer cell line MCF-7(Subarnas et al., 2012). This research has conducted the activity test of chalcone 2',4'‑dihydroxy‑6‑methoxy‑3,5‑dimethyl­chalcone inhibition from Eugenia aquea Burm f. leaves towards lung cancer cell A549 by observation of cell growth profile using MTS assay technique. The result of MTS test showed the value of IC₅₀ at 24 hours observation was 7.47 μg/mL and meanwhile, at 48 hours observation was 5.84 μg/mL.