REVIEW ARTIKEL :WARFARIN DAN INTERAKSINYA DENGAN OBAT OBAT LAIN (ANTIDEPRESAN, ANTIBIOTIK, ANTIINFLAMASI NONSTEROID, DAN PARASETAMOL)

syafira aulia, Resmi Mustarichie

Abstrak


Warfarin sangat populer digunakan sebagai antikoagulan semenjak tahun 1954. Namun, warfarin ini masih memiliki keterbatasan, yakni indeks terapi yang sempit serta interaksinya dengan obat dapat menyebabkan efek yang tidak diinginkan. Obat obat yang memiliki interaksi antara lain sertraline, citalopram-escitalopram, paroxetin, fluvoxamine, fluoxetine, venlafaxine, duloxetin, azithromycin, levofloxacin, trimetoprim /sulfametoksazol, antifungi golongan azol, meloxicam, dan paracetamol. Efek interaksi ini dapat berupa risiko pendarahan, peningkatan International Normalized Ratio (INR) hingga toksisitas warfarin.

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Referensi


Ament, P.W., J.G. Bertolino and J.L. Liszewski. 2000. Clinically Significant Drug Interactions. Am Fam Physician, Vol 61 (6): 1745 – 54.

Bachawati, M. 2010. Anticoagulation and Psychotropic Medications. Curr Psychiatry Rep, Vol 12 (3): 265 – 71.

Bertolini,A., A. Ferrari, A. Ottani, S. Guerzoni, R. Tacchi and S. Leone. 2007. Paracetamol: New Vistas of an Old Drug. CNS Drug Rev, Vol 12 (3): 250 -75.

Choi, K.H., A.J. Kim, I.J. Son, K.K. Hwan, K.K Bong, H. Ahn, et al. 2010. Risk Factor of Drug Interaction between Warfarin and Nonsteroidal Anti-Inflammatory Drugs in Practical Setting. J Korean Med Sci, Vol 25 (3): 337 – 41.

Cozza and Armstrong. 2001. Drug Interaction Principles for Medical Practice. Washington: American Psychiatric Publishing.

Dean, L. 2012. Warfarin Therapy and VKORC1 and CYP Genotype. Available from https://www.ncbi.nlm.nih.gov/books/NBK84174/ [Accessed on July 2nd 2018]

Delaney, J.A., L. Opatrny, J.M. Brophy and S. Suissa. 2007. Drug Drug Interaction between Antithrombotic Medications and The Risk of Gastrointestinal Bleeding. CMAJ, Vol 177(4): 347 – 51.

Fischer, H.D., D.N. Juurlink, M.M. Mamdani, A. Kopp and A. Laupacis. 2010. Hemorrhage During Warfarin Therapy Associated with Contrimoxazole and Other Urinanry Tract Anti-infective Agent. Arch Intern Med, Vol 170 (7): 617 – 21.

Forbes, H.L., and T.M. Polasek. 2017. Potential Drug-Drug Interaction with Direct Oral Anticoagulants in Ederly Hospitalized Patient. Ther Adv Drug Saf , Vol 8 (10): 319 - 28.

Ghaswalla, P.K., S.E. Harpe, D. Tassone and P.W. Slattum. 2012. Warfarin-Antibiotic Interactions in Older Adult of an Outpatient Antikoagulan Clinic. The American Journal of Geriatric Pharmacotherapy, Vol 10 (6): 352- 60.

Goodman and Gilman. 2008. Manual of Pharmacology and Therapeutics. California: Mc-Graw Hill.

Ho, L.H., and T. Brighton. 2002. Warfarin, Antiplatelet Drugs and Their Interactions. Aust Prescr, Vol 25 (4): 81-5.

Jacobs, L.G. 2008. Warfarin Pharmacology, Clinical Management, and Evaluation of Hemorrhagic Risk for the Elderly. Cardiol Clin, Vol 26 (2): 157 – 67.

Johnson, J.A., L. Gong., M.W. Carillo, B.F. Gage, S.A. Scott, C.M. Stein, et al. 2011. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing. Clin Pharmacol Ther, Vol 90 (4): 625 – 29.

Launiainen, T., A. Sajantila, and I. Rasanen, E. Vuori and I. Ojanpera. 2010. Adverse Interaction of Warfarin and Paracetamol: Evidence From a Post-Mortem Study. European Journal of Clinical Pharmacology, Vol 66 (1): 97-103.

Lopes, R.D., J.D. Horowiz, D.A. Garcia, M.A. Crowther and E.M. Hylek. 2011. Warfarin and Acetaminophen Interaction : A Summary of The Evidence and Biologic Plausibility. Blood, 118 (24): 6269 -73.

Monastero, R., R. Camarda and C. Camarda. 2007. Potential Drug-Drug Interaction Between Duloxetine and Acenocoumarol in a Patient with Alzheimers Disease. Clinical Therapeutics, Vol 29 (12) : 2706 – 09.

Nelson, W.W., Wang, L., O. Baser, C.V. Damaraju and J.R. Schein. 2015. Out-of-Range INR Values and Outcomes among New Warfarin Patient with Non-Valvular Atrial Fibrillation. Int J Clin Pharm 37 (1): 53-9.

Oden, A and M. Fahlen. 2002. Oral Anticoagulation and Risk of Death: a Medical Record Linkage Study. BMJ, Vol 325(7372) : 1073-5.

Opatrny, L., J.A.C. Delaney and S. Suissa. 2008. Gastro-intestinal Haemorrhage Risks of Selective Serotonin Receptor Antagonist Therapy: A New Look. British Journal Clinical Pharmacology, Vol 66 (1): 76-81.

Preskorn, S., S.B. Gonzales, and D. Flockhart. 2006. Clinically Relevant Pharmacology of Neuropsychiatric Drugs Approved Over the Last Three Years: Part II. Journal of Psychiatric Practice, Vol 12 (5): 312 – 6.

Sansone, R.A., and L.A. Sansone. 2009. Warfarin and Antidepressants. Psychiatry (Edgmont), Vol 6 (7): 24 -9.

Sayal, K.S., D. McConnel, H.W. McConnel, and D.M. Taylor. 2000. Psychotropic Interactions with Warfarin. Acta Psychiatr Scand, Vol 102 (4): 250 - 5.

Shalansky, S., L. Lynd, K. Richardson, A. Ingaszewski and C. Kerr. 2007. Risk of Warfarin-related Bleeding Events and Supratherapeutic International Normalized Ratios Associated with Complementary and Alternative Medicine: a Longitudinal Analysis. Pharmacotherapy, Vol 27 (9): 1237 – 47.

Teklay, G., N. Shiferaw, B. Legesse and M.L. Bekele. 2014. Drug – Drug Interactions and Risk of Bleeding among Inpatients on Warfarin Therapy: a Prospective Observational Study. Thrombosis Journal, 12 (20): 1 – 8.

Vieira, M.D.L.T, and S.M. Huang. 2012. Botanical-Drug Interactions: a Scientific Perspective. Planta Medica, Vol 78(13): 1400 – 15.

Wardrob, D., and D. Keeling. 2008. The Story of the Discovery of Heparin and Warfarin. British Journal of Haematology, Vol 141 (6): 757 – 63.

Wittkowsky, A.K., S.J. Boccuzzi, J. Wogen, G. Wygant, P. Patel and O. Hauch. 2004. Frequency of Concurrent Use of Warfarin with Potentially Interacting Drugs. Pharmacotherapy, Vol 24 (12): 1668 – 74.




DOI: https://doi.org/10.24198/jf.v16i1.17427

DOI (PDF): https://doi.org/10.24198/jf.v16i1.17427.g8629

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