Email Artikel ini METODE PENAMBAHAN SURFAKTAN SEBAGAI SUBSTRAT PG-P UNTUK MENINGKATKAN KELARUTAN OBAT LIPOFILIK : ARTICLE REVIEW
Abstrak
Saat ini, pengembangan obat berkembang cepat dan terus dilakukan. Salah satu permasalahan formulasi yang mempengaruhi efektivitas obat adalah kelarutan, terutama pada obat dengan kelarutan rendah. Obat-obat yang termasuk BCS kelas II mempunyai sifat permeabilitas tinggi dengan kelarutan rendah karena termasuk obat lipofilik. Metode yang digunakan untuk meningkatkan kelarutan adalah penambahan surfaktan sebagai substrat p-glikoprotein. Tujuan formulasi tersebut adalah mendapatkan bioavailabilitas untuk mencapai efek terapetik. Penambahan surfaktan sudah dibuat dalam berbagai bentuk sediaan, seperti nanokristal, granul, mikroemulsi, dan lain-lain. Hasil dari berbagai penambahan surfaktan dan bentuk sediaan tersebut berfungsi sebagai substrat p-glikoprotein sehingga kelarutan obat lipofilik meningkat dan bioavailabilitasnya menjadi lebih baik.
Kata Kunci: surfaktan, BCS kelas II, kelarutan.
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DOI: https://doi.org/10.24198/jf.v16i2.17620
DOI (PDF): https://doi.org/10.24198/jf.v16i2.17620.g8700
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