REVIEW : STUDI IN-VIVO SEDIAAN TRANSDERMAL KETOPROFEN SEBAGAI ANTIINFLAMASI

QONITA ZAHRA FADHILA, TIANA MILANDA

Abstrak


ABSTRAK

 

Ketoprofen merupakan obat analgesik yang bekerja sebagai antiinflamasi. Bentuk sediaan transdermal ketoprofen lebih efektif dan lebih nyaman digunakan dibandingkan bentuk sediaan lainnya, karena mampu menghantarkan obat ke dalam sistem aliran darah dengan lebih baik juga efek samping yang ditimbulkan lebih ringan. Pengujian sediaan transdermal ketoprofen secara in-vivo telah dilakukan untuk mengetahui distribusi ketoprofen secara intravena dalam beberapa hewan uji, yang dianalisis menggunakan kromatografi cair kinerja tinggi (KCKT).

 

Kata kunci: ketoprofen, transdermal, in-vivo, KCKT.

 

ABSTRACT

 

Ketoprofen is an analgesic drug that works as anti-inflammatory. The ketoprofen transdermal dosage form is more effective and more convenient to use than other dosage forms, as it can deliver the drug into the bloodstream system better and the side effects are milder. In-vivo transdermal ketoprofen dosage form analysis has been performed to determine the distribution of ketoprofen intravenously in some test animals, which were analyzed using high performance liquid chromatography (HPLC).

 

Keywords : ketoprofen, transdermal, in-vivo, HPLC


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Referensi


Adachi , H. 2011. Physical Characteristics, Pharmacological Properties And Clinical Efficacy of The Ketoprofen Patch: A New Patch Formulation. European Review For Medical And Pharmacological Sciences, 15(7).

Ali, A., Afzal, S., Ashraf, M., Amin, S., Javeed, A., Usman, M. 2012. Pharmacokinetic Study of Ketoprofen in Healthy Sheep Under Local Conditions of Pakistan. The Journal of Animal & Plant Sciences, 22(3).

Chien Y.W. 1992. Concepts and System Design for Rate Controlled Drug Delivery, 2nd Ed. New York: Marcel Dekker Inc,

Chien Y.W. 1987. Controlled Drug Delivery: Fundamentals And Applications, 2nd Edn. New York: Marcel Dekker Inc.

Depkes RI. 2014. Farmakope Indonesia Edisi 5. Jakarta:Depkes RI.

Gowda, D.V. 2011. Development And Evaluation Of Ketoprofen Loaded Biopolymerbased Transdermal Film. Der Pharmacia Lettre, 3(3).

Gupta, A.M., Mundhada D.R, Yeole P.G, Pande, V.V. 2007. Studies Of Oleoresins As Penetration Enhancer For Transdermal Patch Of Ketoprofen. Asian Journal Of Pharmaceutics, Vol.1, Issue 1

Hartwig. 2011. Transdermal Delivery Of Ketoprofen Polar Derivatives. United States Patent.

Hosny, M. (2013). Ketoprofen Emulgel: Preparation, Characterization, And Pharmacodinamic Evaluation. International Journal Of Pharmaceutical Sciences Review And Research 20 (2), 306-310.

Patil, P., Praveen, S., Rani, R., & Paradkar, A. (2005). Bioavailability Assessment Of Ketoprofen Incorporated In Gelled Self-Emulsifying Formulation: A Technical Note. Aaps Pharmscitech 6(1).

Rehman, Z.U. Ashraf, M., Khan, M.A., Jabbar, M.A., Rasheed, M.A. 2012. Pharmacokinetics Of Ketoprofen In Healthy Horses In Pakistan. The Journal Of Animal & Plant Sciences, 22(3).

Rehman, Z.U., Ashraf, M., Khan, M.A., Jabbar, M.A., Abbas, M., Khan, M. 2013. Pharmacokinetics Of Ketoprofen In Healthy Buffalo Calves In Pakistan. The Journal Of Animal & Plant Sciences, 23(2).

Tripathi, K.D. 2008. Essentials Of Medical Pharmacology. New Delhi: Jaypee Brothers Medical Publisher (P) Ltd.




DOI: https://doi.org/10.24198/jf.v16i3.17764

DOI (PDF): https://doi.org/10.24198/jf.v16i3.17764.g8992

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