REVIEW ARTIKEL: PENELUSURAN AKTIVITAS ANTIKANKER PAYUDARA DARI TANAMAN SABLO (Acalypha wilkesiana)
Abstrak
ABSTRAK
Menurut Riset Kesehatan Dasar (Riskesdas) 2018, prevalensi kanker di Indonesia meningkat tiap tahunnya. Pada wanita terdapat 2 penyakit kanker dengan penderita terbanyak yang menjadi penyebab kematian, yaitu kanker payudara dan kanker leher rahim. Banyak cara untuk mengani penyakit kanker baik secara medis atau alternatif, seperti tindakan operasi, radiasi, kemoterapi, terapi pijat, terapi bekam, dan lain-lain. Salah satu terapi alternatif yang dianggap aman dan tidak memakan banyak biaya adalah penggunaan tanaman herbal. Metode penulisan review artikel ini adalah studi pustaka. Dalam review artikel ini akan dibahas mengenai bagian tanaman dari Acalypha wilkesiana yang memiliki aktivitas anti kanker payudara. Didapatkan Bagian tanaman dari Acalypha wilkesiana yang memiliki aktivitas anti kanker payudara yaitu daun, biji, dan benih.
Kata kunci: Acalypha wilkesiana, aktivitas anti kanker payudara, kanker payudara
ABSTRACT
According to Basic Health Research (Riskesdas) 2018, the prevalence of cancer in Indonesia is increasing every year. In women, there are 2 cancers with the most sufferers which cause death, namely breast cancer and cervical cancer. There are many ways to treat cancer either medically or alternatively, such as surgery, radiation, chemotherapy, massage therapy, cupping therapy, and others. One alternative therapy that is considered safe and does not cost much is the use of herbs. The method of writing this article review is a literature study. In reviewing this article, we will discuss about the plant part of Acalypha wilkesiana which has anti breast cancer activity. Obtained part of the plant from Acalypha wilkesiana which has anti breast cancer activity namely leaves, seeds, and seeds.
Keywords: Acalypha wilkesiana, anti breast cancer activity, breast cancer
Teks Lengkap:
PDFReferensi
DAFTAR PUSTAKA
Adesina SK, Idowu O, Ogundaini AO, Oladimeji H, Olugbade TA, Onawunmi GO et al. 2000. Antimicrobial constituents of the leaves of Acalypha wilkesiana and Acalypha hispida. Phytother Res, 14: 371-374.
Adhvaryu, M.R., Reddy, N., Parabia, M.H. 2008. Anti-tumor Activity ff Four Ayurvedic Herbs in Dalton Lymphoma Ascites Bearing Mice and their Shortterm In Vitro Cytotoxicity on DLAcell-Line. Afr J Tradit Complement Altern Med, 5: 409-418.
Alwan A, MacLean DR, Riley LM, d’Espaignet ET, Mathers CD, Stevens GA, et al. 2010. Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries. Lancet, 376:1861–1868.
Anokwuru, C P., Sinisi, A.,Samie, A.,TaglialatelaScafati, O. 2015. Antibacterial and antioxidant constituents of Acalypha wilkesiana. Natural Product Research, 29(12): 1180-1183.
Awe, FA., Giwa-Ajeniya, AO., Akinyemi, AA., Ezeri, GNO. 2013. Phytochemical analysis of Acalypha wilkesiana, Leucaena leucocephala, Pepperomia pellucida and Senna alata leaves. The International Journal of Engineering and Sciences (IJES), 2(9):41–44.
Büssing, A., Stein, G., Herterich-Akinpelu, I and Pfüller, U. 1999. Apoptosis associated generation of reactive oxygen intermediates and release of pro-inflammatory cytokines in human lymphocytes and granulocytes by extracts from the seeds of Acalypha wilkesiana. Journal of Ethnopharmacology, 66(3): 301-309.
Chu, Jessica Hoi-Yan. 2014. Investigating in vitro anticancer properties of Malaysian rainforest plants: Acalypha wilkesiana Müll, Arg. Archidendron ellipticum (Blume) Hassk. Duabanga grandiflora Walp. Pseuduvaria macrophylla (Oliv.) Merr. Thesis at the University of Nottingham, University of Nottingham, United Kingdom.
El-raey, M.A., Mohamed, T.K., El-kashak, W.A., Fayad, W.O. 2016. Phenolic Constituents and Biological Activities of Acalypha wilkesiana
F. Tricolor Müll. Arg.Seeds. International Journal of Pharmacognosy and Phytochemical Research, 8(3): 386-392.
Fisher, B., Costantino, J.P., Wickerham, L.D., Cecchini, R.S., Croni, W.M., Robidoux, A., Bevers, T.B., Kavanah, M.T., Atkins, J.N., Margolese, R.G., Runowicz, C.D., James, J.M., Ford, L.G., Wolmark, N., 2005. Tamoxifen for the prevention ofbreast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of National Cancer Institute 97, 1652–1662.
Forcados GE,. Chinyere CN,. Shu ML. 2016. Acalypha wilkesiana: Therapeutic and Toxic Potential. J Med Surg Pathol, 1: 122. doi:10.4172/2472-4971.1000122
GBIF Backbone Taxonomy. 2017. Acalypha wilkesiana Müll.Arg. Tersedia online di https://www.gbif.org/species/3057221 [Diakses pada 29 Mei 2019].
Girish, L., and Vaidya, S. 2018. Research Article : A Review on Acalypha wilkesiana Müll.Arg. International Jounal of Current Reasearch, 10(2): 65323-65329.
Gruiz, K., 1996. Fungitoxic activity of saponins: practical use and fundamental principles. Advances in Experimental Medicine Biology, 404, 527–534.
Gupta, P.B., Kuperwasser, C., 2006. Contributions of estrogen to ER-negative breast tumor growth. Journal of Steroid Biochemistry and Molecular Biology. 102, 71–78.
Hidayat, R.S., dan Napitupulu, R.M. 2015. Kitab Tumbuhan Obat I. Jakarta: Agriflo, hal 121.
Hoshyar, R., Mohaghegh, Z., Torabi, N., And Abolghasemi, A. 2015. Antitumor Activity ff Aqueous Extract Ofziziphus Jujube Fruit in Breast Cancer: An In Vitro and In Vivo Study. Asian Pacific Journal Of Reproduction, 4(2): 116- 122.
Huang, W.Y., Cai, Y.Z., Zhang, Y. 2009. Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention. Nutrition and Cancer, 62(1): 1-20.
Ikewuci, Jude C. 2013. Moderation of hematological and plasma biochemical indices of subchronic salt-loaded rats, by an aqueous extract of the leaves of Acalypha wilkesiana ‘Godseffiana’ Muell Arg (Euphorbiaceae). Asian Pacific Journal of Tropical Medicine, 37-42.
Jia, L., Jin, H., Zhou, J., Chen, L., Lu, Y., Ming, Y. and Yu, Y. 2013. A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways. BMC complementary and alternative medicine, 13(1):33.
Kaplan, M. 2008. The Hispanic Outlook in Higher Education. Paramus, 18(17): 42-44.
Kingsley, O., Marshall, A.A., Inegbenose, I.I., Meg, I.A. 2013. Phytochemical, Proximate and Elemental Analysis of Acalypha Wilkesiana Leaves. Scientific Journal of Pure and Applied Sciences, 2(9): 323-331.
Kingsley, O., and Marshall, A.A. 2014. Medicinal Potential of Acalypha wilkesiana Leaves. Advances in Research, 2(11): 655-665.
Lee, IR., & Yang, MY. 1994. Phenolic Compounds from Duchesnea Chrysantha and Their Cytotoxic Activities in Human Cancer Cell. Archives of pharmacal research, 17(6): 476-479.
Lim, SW, Ting, KN, Bradshaw, TD, Zeenathul, NA., Wiart, C, Khoo, T J and Loh, HS. 2011. Acalypha wilkesiana Extracts Induce Apoptosis by Causing Single Strand and Double Strand DNA Breaks. Journal of ethnopharmacology, 138(2): 616-623.
Michael, HN. 2007. Polyphenolic compounds of the aerial parts of Acalypha wilkesiana. Current Topics in Phytochemistry, 8: 29-32.
Oladunmoye MK. 2006. Comparative evaluation of antimicrobial activities and phytochemical screening of two varieties of Acalypha wilkesiana. Int J Trop Med, 1:134-136.
Ong, H.C. 2006. Tanaman Hiasan: Khasiat Ubatan & Kegunaan Lain. Kuala Lumpur: Utusan Publication and Distribution.
Rao, A.V., Sung, M.K., 1995. Saponins as anticarcinogens. Journal of Nutrition 125, 717S–724S.
Richie, R.C., and Swanson, J.O. 2003. Breast Cancer: A Review of the Literature. J Insur Med, 35:85–101.
Shanmugapriya, R., Ramanathan, T., and Thirunavukkarasu, P. 2011. Evaluation of Antioxidant Potential and Antibacterial Activity of Acalypha indica Linn. Using in vitro Model. Asian Journal of Biomedical and Pharmaceutical Sciences, 1(1): 18-22.
DOI: https://doi.org/10.24198/jf.v17i1.22105
DOI (PDF): https://doi.org/10.24198/jf.v17i1.22105.g12512
Refbacks
- Saat ini tidak ada refbacks.
Sitasi manajer:
Jurnal ini diindeks dalam:
Farmaka by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Copyright © 2013 Jurnal Farmaka - All Right Reserved