Perubahan Disintegran Pada Formula Tablet untuk Efisiensi Biaya Produksi

NADYA GALUH KURNIASARI, Nyi Mekar Saptarini, Dika Pramita Destiani

Abstrak


Formula alternatif diperlukan dalam proses pengembangan formula, formula ini dibuat untuk menurunkan biaya produksi tanpa menurunkan kualitas produk. Pada formula tablet yang akan dikembangkan dilakukan penggantian eksipien yaitu disintegran karena konsentrasi disintegran yang digunakan lebih tinggi jika dibandingkan eksipien lainnya dan memiliki harga yang cukup mahal. Disintegran pada formula sebelumnya adalah croscarmellose sodium dengan 5% yang merupakan jenis superdisintegran. Dalam mengganti disintegran diperlukan studi literatur untuk membandingkan kemampuan disintegran tersebut, selain itu juga harus mempertimbangkan harga dari bahan baku. Hasil studi literatur dan perbandingan harga, menunjukkan bahwa sodium starch glikolat dengan konsentrasi 4% merupakan disintegran yang paling tepat untuk menggantikan croscarmellose sodium.

Kata kunci: Formula alternatif, disintegran, efisiensi biaya.


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Referensi


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DOI: https://doi.org/10.24198/farmaka.v19i4.32278

DOI (PDF): https://doi.org/10.24198/farmaka.v19i4.32278.g16837

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