REVIEW ARTIKEL: KAJIAN PROFIL FITOKIMIA DAN AKTIVITAS FARMAKOLOGI RIMPANG TEMU HITAM (Curcuma aeruginosa Roxb.)
Abstrak
Dalam pengobatan tradisional, berbagai tanaman rimpang-rimpangan seperti kunyit, jahe, temulawak, dan kencur sering dimanfaatkan untuk menjaga kesehatan dan mengobati bermacam penyakit. Salah satu rimpang berkhasiat yang masih jarang diketahui, ialah temu hitam (Curcuma aeruginosa Roxb.). Secara turun-temurun rimpang temu hitam dipercaya dapat mengatasi sakit perut, batuk, asma, kudis, mempercepat pengeluaran lokia selama masa nifas, kegemukan, rematik, kecacingan dan gangguan mental. Dengan ditulisnya review artikel ini diharapkan dapat memberikan informasi tentang kandungan fitokimia beserta beberapa efek farmakologi rimpang temu hitam (C. aeruginosa) yang telah teruji baik secara in vitro, in vivo maupun uji klinis. Semua literatur diperoleh dari Scopus dan Pubmed yang dipilih berdasarkan kriteria inklusi dan eksklusi yang telah ditentukan. Hasil studi diperoleh rimpang temu hitam mengandung alkaloid, flavonoid, tanin, saponin dan terpenoid, dengan kandungan utama berupa senyawa-senyawa turunan terpenoid. Senyawa-senyawa terpenoid inilah yang membuat rimpang temu hitam memiliki aktivitas sebagai antioksidan, anti inflamasi, anti kanker, antidiabetes, antimikroba dan antiandrogen.
Teks Lengkap:
PDFReferensi
Akarchariya, N., Sirilun, S., Julsrigival, J., & Chansakaowa, S. (2017). Chemical profiling and antimicrobial activity of essential oil from Curcuma aeruginosa Roxb., Curcuma glans K. Larsen & J. Mood and Curcuma cf. xanthorrhiza Roxb. collected in Thailand. Asian Pacific Journal of Tropical Biomedicine, 7(10), 881–885. https://doi.org/https://doi.org/10.1016/j.apjtb.2017.09.009
Asiyanbola, I. D., Daniyan, M. O., Opoggen, T. S., Olayemi, I. O., Adeoye, O. B., Ekundina, V. O., & Oyemitan, I. A. (2024). Neuroprotective potentials of the essential oil of Curcuma aeruginosa Roxburg rhizomes in mice with cerebral malaria. Phytomedicine Plus, 4(3), 100581. https://doi.org/https://doi.org/10.1016/j.phyplu.2024.100581
Awin, T., Mediani, A., Maulidiani, Leong, S. W., Muhd Faudzi, S. M., Shaari, K., & Abas, F. (2019). Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics. Journal of Food Composition and Analysis, 77, 66–76. https://doi.org/https://doi.org/10.1016/j.jfca.2019.01.004
Dalimartha, S. (2007). Atlas Tumbuhan Obat Indonesia. Puspa Swara.
Daryanti, E., Asriningtyas, D., & Kautsari, F. (2022). Gambaran Pengetahuan Masyarakat Tentang Macam Rimpang Temu Sebagai Jamu Di Indonesia. Jurnal SENRIABDI, 2(1), 1–8.
Dewi, I. P., Dachriyanus, Aldi, Y., Ismail, N. H., Hefni, D., Susanti, M., Syafri, S., & Wahyuni, F. S. (2024). Curcuma aeruginosa Roxb. Extract Inhibits The Production of Proinflammatory Cytokines on RAW 264.7 Macrophages. International Journal of Applied Pharmaceutics, 16(Special Is), 41–44. https://doi.org/10.22159/ijap.2024.v16s1.08
GBIF Secretariat. (2023). Curcuma aeruginosa Roxb. GBIF Backbone Taxonomy.
Hossain, C. F., Al-Amin, M., Sayem, A. S., Siragee, I. H., Tunan, A. M., Hassan, F., Kabir, M. M., & Sultana, G. N. N. (2015). Antinociceptive principle from Curcuma aeruginosa. BMC Complement Altern Med, 15, 191. https://doi.org/10.1186/s12906-015-0720-6
Kementerian Kesehatan RI. (2012). Vademekum Tanaman Obat (Vol. 3). Kementerian Kesehatan RI.
Panyajai, P., Viriyaadhammaa, N., Tima, S., Chiampanichayakul, S., Dejkriengkraikul, P., Okonogi, S., & Anuchapreeda, S. (2024). Anticancer activity of Curcuma aeroginosa essential oil and its nano-formulations: cytotoxicity, apoptosis and cell migration effects. BMC Complement Med Ther, 24(1), 16. https://doi.org/10.1186/s12906-023-04261-9
Razak, M. R., Afzan, A., Ali, R., Amir Jalaluddin, N. F., Wasiman, M. I., Shiekh Zahari, S. H., Abdullah, N. R., & Ismail, Z. (2014). Effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant Plasmodium falciparum. BMC Complement Altern Med, 14, 492. https://doi.org/10.1186/1472-6882-14-492
Safitri, M., Megawati, S., Aprilliani, A., & Febriyanti, A. (2023). Uji Aktivitas Hepatoprotektor Ekstrak Etanol Rimpang Temu Hitam (Curcuma aeruginosa Roxb.) Pada Mencit Putih (Mus musculus L.) Yang Diinduksi (CCl4). Medical Sains : Jurnal Ilmiah Kefarmasian, 8(3), 1125–1134.
Sillapachaiyaporn, C., Rangsinth, P., Nilkhet, S., Moungkote, N., & Chuchawankul, S. (2021). HIV-1 Protease and Reverse Transcriptase Inhibitory Activities of Curcuma aeruginosa Roxb. Rhizome Extracts and the Phytochemical Profile Analysis: In Vitro and In Silico Screening. Pharmaceuticals (Basel), 14(11). https://doi.org/10.3390/ph14111115
Srivilai, J., Khorana, N., Waranuch, N., Wisuitiprot, W., Suphrom, N., Suksamrarn, A., & Ingkaninan, K. (2016). Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells. Nat Prod Commun, 11(9), 1225–1228. https://www.ncbi.nlm.nih.gov/pubmed/30807005
Srivilai, J., Nontakhot, K., Nutuan, T., Waranuch, N., Khorana, N., Wisuthiprot, W., Scholfield, C. N., Champachaisri, K., & Ingkaninan, K. (2018). Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study. Skin Pharmacol Physiol, 31(2), 99–106. https://doi.org/10.1159/000486136
Srivilai, J., Phimnuan, P., Jaisabai, J., Luangtoomma, N., Waranuch, N., Khorana, N., Wisuitiprot, W., Scholfield, C. N., Champachaisri, K., & Ingkaninan, K. (2016). Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial. Phytomedicine, 25, 29–38. https://doi.org/10.1016/j.phymed.2016.12.007
Srivilai, J., Waranuch, N., Tangsumranjit, A., Khorana, N., & Ingkaninan, K. (2018). Germacrone and sesquiterpene-enriched extracts from Curcuma aeruginosa Roxb. increase skin penetration of minoxidil, a hair growth promoter. Drug Deliv Transl Res, 8(1), 140–149. https://doi.org/10.1007/s13346-017-0447-7
Theanphong, O., Mingvanish, W., & Kirdmanee, C. (2015). Chemical Constituents And Biological Activities Of Essential Oil From Curcuma aeruginosa Roxb. Rhizome. In Science and Technology BHST (Vol. 13, Issue 1).
Tunnisa, F., Nur Faridah, D., Afriyanti, A., Rosalina, D., Ana Syabana, M., Darmawan, N., & Dewi Yuliana, N. (2022). Antioxidant and antidiabetic compounds identification in several Indonesian underutilized Zingiberaceae spices using SPME-GC/MS-based volatilomics and in silico methods. Food Chem X, 14, 100285. https://doi.org/10.1016/j.fochx.2022.100285
Wahyuni, W. T., Batubara, I., & Tambunan, D. Y. (2017). Antibacterial and teeth biofilm degradation activity of Curcuma aeruginosa essential oil. J. Biol. Sci. (Faisalabad), 17(2), 84–90. https://doi.org/10.3923/jbs.2017.84.90
Waras, N., Nurul, K., Muhamad, S., Maria, B., & Ardyani, I. D. A. A. C. (2015). Phytochemical screening, antioxidant and cytotoxic activities in extracts of different rhizome parts from Curcuma aeruginosa RoxB. International Journal of Research in Ayurveda and Pharmacy, 6(5), 634–637. https://doi.org/10.7897/2277-4343.065118
Zheng, J., Sun, P., Sun, N., Hao, Z., Fan, K., Yin, W., Khan, A., Guo, J., Zheng, X., & Li, H. (2022). Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs. BMC Vet Res, 18(1), 453. https://doi.org/10.1186/s12917-022-03531-x
Zohmachhuana, A., Malsawmdawngliana, Lalnunmawia, F., Mathipi, V., Lalrinzuali, K., & Kumar, N. S. (2022). Curcuma aeruginosa Roxb. exhibits cytotoxicity in A-549 and HeLa cells by inducing apoptosis through caspase-dependent pathways. Biomed Pharmacother, 150, 113039. https://doi.org/10.1016/j.biopha.2022.113039
DOI: https://doi.org/10.24198/farmaka.v22i3.56079
DOI (PDF): https://doi.org/10.24198/farmaka.v22i3.56079.g26098
Refbacks
- Saat ini tidak ada refbacks.
##submission.license.cc.by-nc4.footer##
Sitasi manajer:
Jurnal ini diindeks dalam:
Farmaka by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Copyright © 2013 Jurnal Farmaka - All Right Reserved