α-Mangostin dari Buah Manggis, Kandidat Obat Antikanker Baru
Abstrak
Kulit buah manggis memiliki banyak manfaat dalam mengobati berbagai penyakit. Ekstrak dari kulit buah ini telah diuji memiliki aktivitas sebagai antikanker dengan nilai pengambatan 50% kurang. α-mangostin dari kulit manggis telah terbukti memiliki berbagai efek farmakologis diantarnya adalah antioksidant, antiinflamasi, antinyeri, antialergi, antifungi, antibakteri, antiobesitas, antiparasit, antituberkolosis, Alzheimer, dapat meningkatkan sistem imun, dan sebagai anti kanker. Dalam mini review artiken ini didiskusikan terkait bukti-bukti ilmiah anti kanker dari α-mangostin.
Kata kunci : α-mangostin, kanker, buah manggis
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Aisha, A., Abu-Salah, K., Ismail, Z., Abdul, M.A., 2012. in vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract. BMC Complement. Alternat. Med. 12, 104–112.
Hung, S.H., Shen, K.H., Wu, C.H., Liu, C.L., Shih, Y.W., 2009. aMangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinaseplasminogen expression through the JNK signaling pathway. J. Agric Food Chem. 57, 1291–1298.
Ibrahim, Mohamed Yousif, Najihah Mohd Hashim, Abdalbasit Adam Mariod, Syam
Mohan, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab, and Ismail Adam Arbab.
“α-Mangostin from Garcinia mangostana Linn: an updated review of its pharmacological
properties.” Arabian journal of Chemistry 9, no. 3 (2016): 317-329.
Kaomongkolgit, R., Chaisomboon, N., Pavasant, P., 2011. Apoptotic effect of alpha-
mangostin on head and neck squamous carcinoma cells. Arch. Oral Biol. 56, 483–490
Krajarng, A., Nilwarankoon, S., Suksamrarn, S., Watanapokasin, R., 2012. Antiproliferative
effect of a-mangostin on canine osteosarcoma cells. Res. Vet. Sci. 93, 788–794.
Lee, Y.B., Ko, K.C., Shi, M.D., Liao, Y.C., Chiang, T.A., Wu, P.F., Shih, Y.X., Shih, Y.W., 2010. a-
Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9
expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma
cells. J. Food Sci. 75, H13–H23
Matsumoto, K., Akao, Y., Kobayashi, E., Ohguchi, K., Ito, T., Tanaka, T., Iinuma, M., Nozawa,
Y., 2003. Induction of apoptosis by xanthones from mangosteen in human leukemia cell
lines. J. Nat. Prod. 66, 1124–1127.
Matsumoto, K., Akao, Y., Ohguchi, K., Ito, T., Tanaka, T., Iinuma, M., Nozawa, Y., 2005.
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells.
Bioorg. Med. Chem. 13, 6064–6069.
Nabandith, V., Suzui, M., Morioka, T., Kaneshiro, T., Kinjo, T., Matsumoto, K., Akao, Y.,
Iinuma, M., Yoshimi, N., 2004. Inhibitory effects of crude alpha-mangostin, a xanthone
derivative, on two different categorie of colon preneoplastic lesions induced by 1, 2-
dimethylhydrazine in the rat. Asian Pac. J. Cancer Prev. 5, 433–438
Nakagawa, Y., Iinuma, M., Naoe, T., Nozawa, Y., Akao, Y., 2007. Characterized mechanism
of a-mangostin-induced cell death: Caspase-independent apoptosis with release of
endonuclease-G from mitochondria and increased miR-143 expression in human
colorectal cancer DLD-1 cells. Bioorg. Med. Chem. 15, 5620–5628.
Sato, A., Fujiwara, H., Oku, H., Ishiguro, K., Ohizumi, Y., 2004. ALPHA.-mangostin induces
Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells. J Pharmacol.
Sci. 95, 33–40.
Shibata, M.-A., Iinuma, M., Morimoto, J., Kurose, H., Akamatsu, K., Okuno, Y., Akao, Y.,
Otsuki, Y., 2011. a-Mangostin extracted from the pericarp of the mangosteen (Garcinia
mangostana Linn) reduces tumor growth and lymph node metastasis in an
immunocompetent xenograft model of metastatic mammary cancer carrying a p53
mutation. BMC Med. 9, 69–76.
Shih, Y.W., Chien, S.T., Chen, P.S., Lee, J.H., Wu, S.H., Yin, L.T., 2010. a-Mangostin
suppresses phorbol 12-myristate 13-acetateinduced MMP-2/MMP-9 expressions via avb3
integrin/FAK/ERK and NF-jB signaling pathway in human lung adenocarcinoma A549
cells. Cell Biochem. Biophys. 58, 31–44
Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N.,
Suksamrarn, A., 2006. Cytotoxic prenylated xanthones from the young fruit of Garcinia
mangostana. Chem. Pharm. Bull. 54, 301–305.
Verma, R. K. et al. α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic
carcinogenesis by targeting cancer stem cells in human, and transgenic (KrasG12D, and
KrasG12D/tp53R270H) mice. Sci. Rep. 6, 32743; doi:Wang, J.J., Sanderson, B.J.S., Zhang, W., 2011. Cytotoxic effect of xanthones from pericarp
of the tropical fruit mangosteen (Garcinia mangostana Linn.) on human melanoma cells.
Food Chem. Toxicol. 49, 2385–2391.
Yoo, J.-H., Kang, K., Jho, E.H., Chin, Y.-W., Kim, J., Nho, C.W., 2011. a- and c-mangostin
inhibit the proliferation of colon cancer cells via b-catenin gene regulation in Wnt/cGMP
signalling. Food Chem. 129, 1559–1566 10.1038/srep32743 (2016).
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