Review : In Situ Gel Optalmik

Lutfiah Yusuf, Iyan Sopyan

Abstrak

In situ gel optalmik merupakan sediaan gel untuk mata yang awalnya berupa larutan, namun ketika diteteskan pada mata akan berubah menjadi gel sehingga waktu kontak dengan mata akan lebih lama. Pembuatan in situ gel menggunakan matriks-matriks yang mengental apabila berada pada kondisi fisiologi tertentu seperti pH, suhu dan konsentrasi ion. Sediaan optalmik konvensional seperti larutan, suspense dan salep memiliki kelemahan yaitu waktu kontak yang singkat dengan kornea mata serta tidak nyaman digunakan. In situ gel dibuat untuk mengatasi kelemahan atau kekurangan yang terkait dengan drug delivery system (Sistem Penghantaran Obat) dan memiliki potensi yang besar untuk dijadikan sebagai ocullar therapy karena memiliki waktu kontak yang lama dengan kornea mata.

Kata Kunci : In situ gel, Optalmik, Sistem penghantaran obat.

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/farmasetika.v4i4.23065

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