Formulasi Nanopartikel Tanaman Herbal Untuk Terapi Kanker

AI Masitoh, Iyan Sopyan

Abstrak

Kanker termasuk masaalah kesehatan utama di Dunia dan termasuk penyebab kematian nomor dua setelah kardiovaskular. Obat herbal saat ini banyak digunakan untuk pengobatan kanker karena kelimpahan senyawa kimianya yang berpotensi sebagai anti-kanker. Namun tanaman herbal kebanyakan sediaannya kurang larut air dan memiliki bioavailabilitas yang kurang baik. Sehingga perlu dilakukan modifikasi secara fisik ataupun kimia untuk meningkatkan kelarutannya. Salahsatu modifikasi secara fisik yaitu dari segi Formulasi. Nanopartikel adalah salah satu formulasi yang dapat mengatasi masalah-masalah tersebut karena Nanopartikel mampu memperbaiki kelarutan obat herbal dan dapat masuk dan menargetkan sel kanker secara spesifik.

Kata kunci : kanker, nanopartikel, tanaman herbal

Teks Lengkap:

PDF

Referensi

Ambarwati , R. & Rahmawati , A., 2017. Pengembangan Sistem Pembawa Albumin Nanopartikel Untuk Silimarin Dan Kajian Sifat Fisik Serta Profil Pelepasannya Secara In Vitro. Fitofarmaka No. 2, 7(ISSN:2087-9164).

Andasari , S. D., 2017. Formulasi Nanopartikel Zerumbon dari Rimpang Lempuyang Gajah (Zingiber zerumbet L.) : Enkapsulasi dengan Kitosan dan Aktivitas Sitotoksiknya Terhadap Sel Kanker T47D. Jurnal UMS.

Bhardwaj, V., Naga , M. & Kumar, V. R., 2006. Polymeric nanoparticles for oral drug delivery. In: Gupta, R.B., Kompella, U.B. (Eds.), Nanoparticle Technology for Drug Delivery. Taylor & Francis Group, New York, US, pp. 231-271.

Daoud, A., Song, J., Xiao, F. & Shiang , J., 2014. B-9-3, a novel b-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro.. Eur. J. Pharmacol. 5 (724), pp. 219-230.

Depkes RI, 2007. Keputusan Menteri Kesehatan Republik Indonesia Nomor : 812/Menkes/SK/ VII/2007 Tentang Kebijakan Perawatan Paliatif.. Jakarta: Depkes RI.

Depkes RI, 2009. Pencegahan Kanker Leher Rahim dan Kanker Payudara.. Jakarta: Direktorat Pengendalian Penyakit Tidak Menular Direktorat Jenderal PPP Departemen Kesehatan RI.

Ding, C. et al., 2013. Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.. J. Med. Chem, 12(56), pp. 5048-5058.

Edityaningrum, C. A. & Rachmawati , H., 2015. Peningkatan Stabilitas Kurkumin Beta Siklodekstrin Nanopartikel Dalam Bentuk Gel.. Pharmaҫiana, 05(01), pp. 53-60.

Gamboa, J. M. & Leong , K. W., 2013. In vitro and in vivo models for the study of oral delivery of nanoparticles.. Adv. Drug Deliv. Rev., 6(65), pp. 800-810.

Howlader , N. et al., 2016. SEER Cancer Statistics Review, 1975–2011. National Cancer Institute, Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/.

Keen, J., 2008. Commentary: a step towards a new targeted nanotherapy for pancreatic cancer.. Cancer Biol Ther 2008;7(10):1591-2..

Khakim, A. N. & Atun , S., 2017. . The Preparation Of Kunci Pepet (Kaempferia rotunda) Extract Nanoparticles Loaded Alginate With Various Calsium Ion Concentration Calsium Concentration.. Jurnal Kimia Dasar, 6(1).

Koval, A. V. et al., 2014. Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling.. Biochem. Pharmacol., 4(87), pp. 571-578.

Lakshmi , V. & Bai , G. V. S., 2016. Anticancer Activity of Clerodendrum Phlomidis (L) Leaves and Its Nanoparticles. .. World Journal of Science and Research, 1(1), pp.12–25.

Lakshmi, V. & Bai, G. V. S., 2016. In Vitro Anticancer Activity of Clerodendrum phlomidis Leaves and Its Silver Nanoparticles on Human Breast Cancer Cell Line (MCF-7). .. Asian Journal of Innovative Research, 1(2), pp.1–5.

Li, S. D. & Huang, L., 2008. Pharmacokinetics and biodistribution of nanoparticles.. Mol. Pharm. 5 (4), 496–504 (PubMed PMID: 18611037)..

Liu, M., Dong , J., Yang , Y. & Xu, H., 2005. Anti-inflammatory effects of triptolide loaded poly (d.l-lactic acid) nanoparticles on an adjuvant-induced arthritis in rats.. J Ethnopharmacology 2005;97:219-225..

Mathiowitz, E. et al., 1997. Biologically erodable microspheres as potential oral drug delivery systems.. Nature 386 (6623), 410–414 (PubMed PMID: 9121559)..

Moschwitzer, J. & Miller , R. H., 2007. Drug nanocrystals – the universal formulation approach for poorly soluble drugs. In: Thassu, D., Dellers, M., Pathak, Y. (Eds.), Nanoparticulate Drug Delivery Systems.. Informa Healthcare USA Inc, New York, US, pp. 71–88..

Nagdeva, Katiyar, P. K. & Singh, R., 2012. Anticancer Activity of Leaves of Clerodendron Serratum Spreng. Am.. J. PharmTech Res, 2(4), pp.452–461..

Napsah, R. & Wahyuningsih, I., 2014. Preparasi Nanopartikel Kitosan-TPP/Ekstrak Etanol Daging Buah Mahkota Dewa (Phaleriamacrocarpa (Scheff) Boerl) Dengan Metode Gelasi Ionik.. Jurnal Farmasi Sains dan Komunitas No. 1. ISSN : 1693-5683., 11(01), pp. 7-12.

National Cancer Institue, 2006. Fact Sheet: Drug Discovery at the National Cancer Institute. National Institute of Health. [Online]

Available at: http://www.cancer.gov/cancertopics/factsheet/NCI/drugdiscovery

[Accessed 15 juny 2019].

Newman , D. J. & Cragg, G. M., 2007. Natural products as sources of new drugs over the last 25 years.. J Nat Prod. 2007;70:461-477..

Ningsi , S., 2013. Formulasi dan Karakterisasi Nanokapsul dari Ekstrak Daun Parang Romang (Boehmeria virgata (Forst) Guill) Berdasarkan Variasi Konsentrasi Inti dan Penyalut.. JF FIK UINAM Vol.1 No. 1.

Ningsih , N., Yasni , S. & Yulianti , S., 2017. Nanoparticle of Red Mangosteen Peel Extract Synthesis and the Functional Characteristics of Its Encapsulated Products.. J. Teknol. dan Industri Pangan. Vol. 28(1): 27-35 Th. 2017 ISSN: 1979-7788.

Pertiwi , R., Djajadisastra, J., Mutalie , A. & Pujiyanto , A., 2018. Pembuatan, Karakterisasi dan Uji In Vitro Nanopartikel Emas Berbasis Konjugat Gom Arab-Vinkristin.. Jurnal Ilmu Kefarmasian Indonesia, 16(ISSN 1693-1831), pp. 6-11.

Raman , R. P., 2015. Biogenic Silver Nanoparticles Synthesis Using The Extract of The Medicinal Plant Clerodendron serratum and Its In-Vitro Antiproliferative Activity.. Materials Letters. Available at: http://dx.doi.org/10.1016/j. Acces on : 15/06/2019.

Riki, Ambarsari, L. & Nurcholis , W., 2017. Potensi Nanopartikel Ekstrak Kurkuminoid Temulawak Terhadap Sel Line Kanker Serviks.. Indonesia Natural Research Pharmaceutical Journal, 2(01).

Sarkar , F. H., Li, Y., Wang , Z. & Padhye , S., 2010. Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs.. Curr Pharm Des., pp. 1801-1812.

Savjani , K. T., Gajjar , A. K. & Savjani, J. K., 2012. Drug solubility: importance and enhancement techniques. ). ISRN Pharm. 2012, 195727 (PubMed PMID: 22830056.

Tsuda, A. & Peter , G., 2015. Nanoparticles in the lung environmental exposure and drug delivery. CRC Press. Amerika Serikat. E-book. https://onlybooks.org/nanoparticles-in-the-lung-environmental-exposure-and-drug-delivery-18241.. [Online]

Available at: https://onlybooks.org/nanoparticles-in-the-lung-environmental-exposure-and-drug-delivery-18241.

[Accessed 15 Juny 2019].

Refbacks

  • Saat ini tidak ada refbacks.