Etosom sebagai Penghantar Obat Herbal Hidrofilik

Luthfia Azzahra, Ida Musfiroh

Abstrak

Sediaan herbal banyak mengandung zat aktif yang bersifat hidrofilik, sehingga terdapat masalah utama jika dibuat dalam bentuk sediaan topikal, yaitu saat proses penghantaran dan penetrasi obat menembus kulit. Oleh karena itu sebagai upaya untuk mengatasi masalah tersebut, berkembang sistem penghantaran menggunakan etosom. Etosom merupakan nanovesikel elastis dengan kandungan fosfolipid dan alkohol (>20%), yang dapat berpenetrasi menembus lapisan kulit terluar stratum corneum. Mekanisme kerjanya diduga karena kandungan alkohol dan fosfolipid yang terdapat dalam etosom. Tujuan dari review artikel ini diharapkan dapat memberikan informasi terkait etosom sebagai penghantar untuk obat herbal hidrofilik. Metode yang digunakan yaitu dengan mengumpulkan berbagai jurnal seputar etosom sebagai penghantar obat herbal. Hasil menunjukkan etosom sebagai penghantar obat herbal meningkatkan permeabilitas obat. Etosom dapat digunakan sebagai penghantar obat herbal.

Kata kunci : Etosom, Hidrofil, Herbal, Topikal

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/farmasetika.v3i4.23483

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