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Pengaturan Pelepasan Obat dari Tablet dengan Sistem Matriks Karagenan
Abstrak
Sistem matriks merupakan sistem pengaturan pelepasan obat dari tablet yang populer. Matriks tablet yang umum digunakan adalah golongan eter selulosa seperti hidroksi propil metil selulosa (HPMC), hidroksi propil selulosa (HPC) dan natrium karboksi metil selulosa (Na CMC). Golongan eter selulosa sintetik ini banyak digunakan karena memiliki sifat mengembang dan kompresibilitas yang baik. Polimer alam seperti karagenan telah banyak diteliti sebagai komponen penyusun matriks tablet untuk memperoleh pengaturan pelepasan obat dari matriks yang efektif. Karagenan dapat digunakan sebagai penyusun matriks mengingat polimer tersebut memiliki berat molekul yang besar dan mempunyai viskositas dan kemampuan membentuk gel yang tinggi. Dalam upaya pengembangan sistem matriks tablet dari bahan karagenan diperlukan pengetahuan yang baik mengenai karakteristik fisika kimia dari karagenan dan obat yang digunakan.
Kata kunci : sistem matriks, karagenan, pembentukan gel.
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