Stabilisasi Tablet yang Mengandung Zat Aktif Bersifat Higroskopis

Fitri Nurjanah, Sriwidodo Sriwidodo, Bambang Nurhadi

Abstrak

Rute pemberian obat secara oral banyak disukai masyarakat karena mudah digunakan. Salah satu bentuk sediaan oral yang paling disukai adalah tablet. Tablet adalah bentuk sediaan padat yang mengandung bahan aktif dengan atau tanpa eksipien. Dalam formulasi tablet, kandungan air zat obat dan eksipien padat merupakan parameter penting yang harus dipantau selama proses pengembangan produk obat. Pada sediaan padat, senyawa yang bersifat higroskopis dapat menimbulkan masalah yang dapat mempengaruhi aliran serbuk, kompresibilitas, dan kekerasan tablet. Pada review artikel ini akan di bahas mengenai pengaruh kelembapan terhadap karakteristik fisika tablet dan upaya menjaga stabilitas zat aktif yang sensitif terhadap kelembapan. Review ini menyimpulkan bahwa pemilihan eksipien, penyalutan tablet dan kemasan yang tepat dapat menjaga kestabilan tablet dari pengaruh kelembapan.

Kata Kunci

Tablet, zat aktif, stabilisasi, higroskopis

Teks Lengkap:

PDF

Referensi

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DOI: https://doi.org/10.24198/mfarmasetika.v6i1.27420

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