Stabilisasi Liposom dalam Sistem Penghantaran Obat

Sausan Rihhadatulaisy, Sriwidodo Sriwidodo, Norisca Aliza Putriana

Abstrak

Enkapsulasi obat dalam liposom telah memberikan peluang untuk meningkatkan terapeutik dan kestabilan pada berbagai senyawa aktif. Peran liposom sebagai sistem penghantaran obat adalah untuk memberikan obat dengan cara terkontrol, mengurangi toksisitas, dan meningkatkan kemanjuran obat yang dienkapsulasi. Meskipun liposom secara luas telah dipelajari dalam bidang farmasi, liposom memiliki masalah terkait dengan kestabilan, diantaranya partikel membentuk agregat, koalesensi, fusi, dan terjadinya kebocoran obat dalam vesikel yang disebabkan oleh beberapa faktor seperti suhu, pH, muatan permukaan, maupun komposisi lipid. Maka dari itu, studi stabilitas fisik diperlukan untuk menjamin integritas produk. Dari hasil review artikel dengan metode pencarian studi pustaka pada beberapa jurnal, didapatkan teknik untuk menjaga stabilitas liposom diantaranya, aktivasi tepi dengan surfaktan seperti tween dan polietilen glikol, modifikasi permukaan liposom dengan kitosan, polisakarida,dan poliekektrolit, pengeringan beku, serta penggabungan dengan polimer gel. Oleh karena itu, artikel ini dimaksudkan untuk membahas mengenai stabilisasi liposom dan berbagai parameter karakterisasi diantaranya, ukuran partikel, efisiensi penjerapan, muatan dan morfologi permukaan sebagai tolak ukur untuk stabilitas liposom.

Kata Kunci

Liposom, Stabilitas, karakterisasi, dan penghantaran obat.

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/mfarmasetika.v5i5.27456

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