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Design-Expert Software sebagai Alat Optimasi Formulasi Sediaan Farmasi
Abstrak
Salah satu tahap dalam pengembangan obat adalah formulasi untuk mendapatkan formula yang optimum. Dengan formula yang optimum maka kualitas sediaan baik dan memenuhi parameter-parameter baku. Tahap ini dilakukan melalui eksperimen laboratorium dan analisis hasil percobaan yang umunya cukup memakan waktu. Untuk mengatasi hal tersebut dapat dilakukan pendekatan menggunakan piranti lunak dengan teknologi komputer yaitu Design-Expert software dalam membantu mendesain variasi formula pada preformulasi dan analisis hasil percobaan post formulasi. Tujuan dari review ini adalah muntuk mengetahui pemanfaatan Design-Expert software dalam penelitian formulasi dan optimasi. Metode penulisan kajian pustaka dilakukan dengan pencarian pada Google scholar dan ScinceDirect dengan kata kunci “Formulation” dan “Design-Expert” menghasilkan penemuan 63 artikel dan skrining dengan menerapkan kriteria inklusi yaitu artikel penelitian optimasi formulasi dengan rentang tahun terbit antara 2011 – April 2020 dan eksklusi berupa artikel berbentuk review artikel. Berdasarkan hasil kajian pustaka dapat disimpulkan bahwa Design-Expert software banyak digunakan dan bermanfaat dalam mengurangi waktu, dan biaya pengembangan formulasi.
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