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Pendekatan Nanoteknologi Untuk Penghantaran Bahan Aktif Farmasi Dalam Terapi Acne Vulgaris
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Jerawat (Acne vulgaris) adalah kelainan kulit yang terjadi akibat penumpukan sebum yang dihasilkan oleh kelenjar minyak yang ada di kulit. Penumpukan sebum tersebut akan menstimulus pertumbuhan P. acne yang akan menyebabkan pertumbuhan jerawat. Terapi untuk jerawat telah banyak dikembangkan untuk berbagai bahan aktif dan metode yang digunakan sudah beragam dari yang konvensional hingga teknologi terbarukan. Penghantaran terbarukan seperti nanoteknologi dipilih karena dapat meningkatkan stabilitas bahan aktif, meningkatkan penetrasi pada kulit serta dapat menghantarkan zat aktif ke daerah terapi yang tertarget. Tujuan: review yang disusun untuk menjadi bahan acuan komprehensif mengenai jerawat. Metode: metode yang digunakan adalah pengumpulan artikel ilmiah dari sumber nasional dan internasional. Hasil: hasil yang didapatkan adalah metode nanopartikel adalah metode yang paling baik dalam penghantaran sediaan topikal khususnya untuk terapi jerawat. Adapun berbagai pengembangan terbarukan yaitu lipid nanopartikel, polimer nanopartikel dan metal nanopartikel. Review ini akan mengulas secara lengkap berbagai studi mengenai penghantaran terbarukan zat aktif dalam penghantaran nano teknologi untuk terapi jerawat.
Kata Kunci: Jerawat, Kulit, Nanopartikel,
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A. H. S. Heng and F. T. Chew, “Systematic review of the epidemiology of acne vulgaris,” Sci. Rep., vol. 10, no. 1, p. 5754, Apr. 2020, doi: 10.1038/s41598-020-62715-3.
F. A. Khamdan, M. A. Shah, M. A. Khamdan, and E. Albasri, “Acromegaly Presenting with Resistant Acne Vulgaris,” Case Rep. Dermatol., vol. 14, no. 2, pp. 151–156, May 2022, doi: 10.1159/000525069.
M. Bertolani et al., “The influence of Mediterranean diet in acne pathogenesis and the correlation with insulin-like growth factor-1 serum levels: Implications and results,” Dermatol. Rep., vol. 14, no. 1, Dec. 2021, doi: 10.4081/dr.2022.9143.
N. Afshari, M. Amirnia, D. Ahmadi, S. Kashefi, and V. Aghamohammadi, “Comparing the efficacy of intense pulsed light combined with oral azithromycin versus oral azithromycin alone in the treatment of moderate to severe papulopustular acne vulgaris,” Med. J. Tabriz Univ. Med. Sci. Health Serv., vol. 42, no. 6, pp. 621–626, Feb. 2021, doi: 10.34172/mj.2021.001.
M. Elmowafy et al., “Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies,” Int. J. Pharm., vol. 572, p. 118781, Dec. 2019, doi: 10.1016/j.ijpharm.2019.118781.
W. Sonyot et al., “In Vitro Antibacterial and Anti-Inflammatory Effects of Novel Insect Fungus Polycephalomyces phaothaiensis Extract and Its Constituents against Propionibacterium acnes,” Antibiotics, vol. 9, no. 5, p. 274, May 2020, doi: 10.3390/antibiotics9050274.
A. H. S. Heng, Y.-H. Say, Y. Y. Sio, Y. T. Ng, and F. T. Chew, “Epidemiological Risk Factors Associated with Acne Vulgaris Presentation, Severity, and Scarring in a Singapore Chinese Population: A Cross-Sectional Study,” Dermatology, vol. 238, no. 2, pp. 226–235, 2022, doi: 10.1159/000516232.
A. M. O’Neill et al., “Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne,” Sci. Transl. Med., vol. 14, no. 632, p. eabh1478, Feb. 2022, doi: 10.1126/scitranslmed.abh1478.
N. Kirsten, N. Mohr, and M. Augustin, “Prevalence and Cutaneous Comorbidity of Acne Vulgaris in the Working Population,” Clin. Cosmet. Investig. Dermatol., vol. Volume 14, pp. 1393–1400, Oct. 2021, doi: 10.2147/CCID.S322876.
P. Mawardi, I. Ardiani, P. P. Primisawitri, and A. Nareswari, “Dual role of Cutibacterium acnes in acne vulgaris pathophysiology,” Bali Med. J., vol. 10, no. 2, pp. 486–490, May 2021, doi: 10.15562/bmj.v10i2.2358.
S. Ahmad Nasrollahi, F. Koohestani, A. Naeimifar, A. Samadi, A. Vatanara, and A. Firooz, “Preparation and evaluation of adapalene nanostructured lipid carriers for targeted drug delivery in acne,” Dermatol. Ther., vol. 34, no. 2, Mar. 2021, doi: 10.1111/dth.14777.
A. Darjani et al., “Efficacy safety and tolerability of dapsone 5% gel and benzoyl peroxide 5% gel in combination with oral doxycycline in treating moderate acne vulgaris: a randomized clinical trial,” Iran. J. Dermatol., vol. 25, no. 2, Jun. 2022, doi: 10.22034/ijd.2021.273824.1324.
J. Tan, R. Bissonnette, D. Gratton, N. Kerrouche, and J. M. Canosa, “The safety and efficacy of four different fixed combination regimens of adapalene 0.1%/benzoyl peroxide 2.5% gel for the treatment of acne vulgaris: results from a randomised controlled study,” Eur. J. Dermatol., vol. 28, no. 4, pp. 502–508, Jul. 2018, doi: 10.1684/ejd.2018.3367.
N. Hayashi et al., “Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed-dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, invest,” J. Dermatol., vol. 45, no. 8, pp. 951–962, Aug. 2018, doi: 10.1111/1346-8138.14497.
A. Bisht et al., “Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne,” Drug Deliv. Transl. Res., vol. 12, no. 10, pp. 2501–2517, Oct. 2022, doi: 10.1007/s13346-021-01092-4.
V. D. Callender, H. Baldwin, F. E. Cook-Bolden, A. F. Alexis, L. Stein Gold, and E. Guenin, “Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice,” Am. J. Clin. Dermatol., vol. 23, no. 1, pp. 69–81, Jan. 2022, doi: 10.1007/s40257-021-00643-2.
K. Chilicka, A. M. Rogowska, R. Szyguła, and J. Taradaj, “Examining Quality of Life After Treatment with Azelaic and Pyruvic Acid Peels in Women with Acne Vulgaris,” Clin. Cosmet. Investig. Dermatol., vol. Volume 13, pp. 469–477, Jul. 2020, doi: 10.2147/CCID.S262691.
S. St. Surin-Lord and J. Miller, “Topical Treatment of Truncal Acne with Tretinoin Lotion 0.05% and Azelaic Acid Foam,” Case Rep. Dermatol. Med., vol. 2020, pp. 1–5, Mar. 2020, doi: 10.1155/2020/5217567.
I. Tomić, S. Miočić, I. Pepić, D. Šimić, and J. Filipović-Grčić, “Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris,” Pharmaceutics, vol. 13, no. 4, p. 567, Apr. 2021, doi: 10.3390/pharmaceutics13040567.
E. Touitou and H. Natsheh, “Topical Administration of Drugs Incorporated in Carriers Containing Phospholipid Soft Vesicles for the Treatment of Skin Medical Conditions,” Pharmaceutics, vol. 13, no. 12, p. 2129, Dec. 2021, doi: 10.3390/pharmaceutics13122129.
K. Balighi, M. Daneshpazhooh, V. Lajevardi, S. Talebi, and A. Azizpour, “Cheilitis in acne vulgaris patients with no previous use of systemic retinoid products,” Australas. J. Dermatol., vol. 58, no. 3, pp. 211–213, Aug. 2017, doi: 10.1111/ajd.12476.
M. Yaldiz, A. Kara, M. Güven, B. Solak, R. Kara, and M. T. Erdem, “Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-cis retinoid) therapy for acne vulgaris,” Adv. Dermatol. Allergol., vol. 37, no. 3, pp. 360–363, 2020, doi: 10.5114/ada.2018.79566.
S. E. Koçyi̇Ği̇T, M. Şahi̇N, Y. Houshyar, F. S. Dost Günay, and D. Çorapçioğlu, “Effects of Isotretinoin Treatment on Levels of Hormones Involved in the Etiopathogenesis of Acne,” Turk. J. Endocrinol. Metab., vol. 24, no. 3, pp. 237–246, 2020, doi: 10.25179/tjem.2020-75230.
E. Soebakti, M. Y. Listiawan, and E. Ervianti, “Kadar Hormon 17Α-Hydroxyprogesteron (17-OHP) Serum pada Pasien Pria dengan Akne Vulgaris Sedang-Berat dan tanpa Akne Vulgaris,” vol. 30, no. 1, 2018.
F. Tuğcu-Demiröz, S. Saar, A. A. Kara, A. Yıldız, E. Tunçel, and F. Acartürk, “Development and characterization of chitosan nanoparticles loaded nanofiber hybrid system for vaginal controlled release of benzydamine,” Eur. J. Pharm. Sci., vol. 161, p. 105801, Jun. 2021, doi: 10.1016/j.ejps.2021.105801.
S. L. Patwekar, S. R. Pedewad, and S. Gattani, “Development and evaluation of nanostructured lipid carriers-based gel of isotretinoin,” Part. Sci. Technol., vol. 36, no. 7, pp. 832–843, Oct. 2018, doi: 10.1080/02726351.2017.1305026.
R. Goyal, L. K. Macri, H. M. Kaplan, and J. Kohn, “Nanoparticles and nanofibers for topical drug delivery,” J. Controlled Release, vol. 240, pp. 77–92, Oct. 2016, doi: 10.1016/j.jconrel.2015.10.049.
F. C. Iswanti, I. Nurulita, S. Djauzi, M. Sadikin, A. B. Witarto, and T. Yamazaki, “Preparation, characterization, and evaluation of chitosan-based nanoparticles as CpG ODN carriers,” Biotechnol. Biotechnol. Equip., vol. 33, no. 1, pp. 390–396, Jan. 2019, doi: 10.1080/13102818.2019.1578690.
E. Alğin Yapar, “CİLT BEYAZLATICILARA GENEL BAKIŞ,” Marmara Pharm. J., vol. 21, no. 24530, pp. 48–53, Sep. 2016, doi: 10.12991/marupj.259880.
P. Dhillon, Mohd. A. Mirza, Md. K. Anwer, A. S. Alshetaili, S. M. Alshahrani, and Z. Iqbal, “Development and optimization of erythromycin-loaded lipid-based gel by Taguchi design: In vitro characterization and antimicrobial evaluation,” Braz. J. Pharm. Sci., vol. 55, p. e17395, 2019, doi: 10.1590/s2175-97902019000217395.
N. Fatima, S. Rehman, B. Nabi, S. Baboota, and J. Ali, “Harnessing nanotechnology for enhanced topical delivery of clindamycin phosphate,” J. Drug Deliv. Sci. Technol., vol. 54, p. 101253, Dec. 2019, doi: 10.1016/j.jddst.2019.101253.
S. Tolentino, M. N. Pereira, M. C. de Sousa, M. Cunha-Filho, G. M. Gelfuso, and T. Gratieri, “The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases,” J. Drug Deliv. Sci. Technol., vol. 59, p. 101895, Oct. 2020, doi: 10.1016/j.jddst.2020.101895.
F. M. Abdelhamed, N. F. Abdeltawab, M. T. ElRakaiby, R. N. Shamma, and N. A. Moneib, “Antibacterial and Anti-Inflammatory Activities of Thymus vulgaris Essential Oil Nanoemulsion on Acne Vulgaris,” Microorganisms, vol. 10, no. 9, p. 1874, Sep. 2022, doi: 10.3390/microorganisms10091874.
K. M. Hosny, K. S. Al Nahyah, and N. A. Alhakamy, “Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment,” Pharmaceutics, vol. 13, no. 1, p. 46, Dec. 2020, doi: 10.3390/pharmaceutics13010046.
K. Begum, A. Sarker, I. J. Shimu, M. M. I. Chowdhury, and R. U. Jalil, “Characterization of Nanoemulsion Prepared from Self-emulsifying Rifampicin and its Antibacterial Effect on Staphylococcus aureus and Stap. epidermidis Isolated from Acne,” Dhaka Univ. J. Pharm. Sci., vol. 14, no. 2, pp. 171–177, Jun. 2016, doi: 10.3329/dujps.v14i2.28507.
S. Wunnoo et al., “Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris,” Antibiotics, vol. 10, no. 2, p. 108, Jan. 2021, doi: 10.3390/antibiotics10020108.
C. Sankar, S. Muthukumar, G. Arulkumaran, S. Shalini, R. Sundaraganapathy, and S. joji samuel, “Formulation and Characterization of Liposomes containing Clindamycin and Green tea for Anti Acne,” Res. J. Pharm. Technol., vol. 12, no. 12, p. 5977, 2019, doi: 10.5958/0974-360X.2019.01038.2.
B. A. Habib, N. F. Abdeltawab, and I. Salah Ad-Din, “D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes,” Drug Deliv., vol. 29, no. 1, pp. 821–836, Dec. 2022, doi: 10.1080/10717544.2022.2048131.
F. Kashani-Asadi-Jafari and A. Hadjizadeh, “1 Niosome encapsulated doxycycline-hyclate for potentiation of acne therapy: 2 formulation and characterization”.
K. Begum, A. F. Khan, H. K. Hana, J. Sheak, and R. U. Jalil, “Rifampicin Niosome: Preparations, Characterizations and Antibacterial Activity Against Staphylococcus aureus and Staphylococcus epidermidis Isolated from Acne,” Dhaka Univ. J. Pharm. Sci., vol. 14, no. 1, pp. 117–123, Jun. 2015, doi: 10.3329/dujps.v14i1.23744.
A. Mistry and P. Ravikumar, “Development and Evaluation of Azelaic Acid Based Ethosomes for Topical Delivery for the Treatment of Acne,” Indian J. Pharm. Educ. Res., vol. 50, no. 3s, pp. S232–S243, Aug. 2016, doi: 10.5530/ijper.50.3.34.
R. R. Mustofa and . I., “PREPARATION AND CHARACTERIZATION OF ANTI-ACNE ETHOSOMES USING COLD AND THIN-LAYER HYDRATION METHODS,” Int. J. Appl. Pharm., vol. 10, no. 1, p. 338, Dec. 2018, doi: 10.22159/ijap.2018.v10s1.75.
Z. Yu, H. Lv, G. Han, and K. Ma, “Ethosomes Loaded with Cryptotanshinone for Acne Treatment through Topical Gel Formulation,” PLOS ONE, vol. 11, no. 7, p. e0159967, Jul. 2016, doi: 10.1371/journal.pone.0159967.
R. Bnyan et al., “Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic,” J. Pharm. Pharmacol., vol. 71, no. 10, pp. 1508–1519, Sep. 2019, doi: 10.1111/jphp.13149.
H. Park et al., “Lipase-Sensitive Transfersomes Based on Photosensitizer/Polymerizable Lipid Conjugate for Selective Antimicrobial Photodynamic Therapy of Acne,” Adv. Healthc. Mater., vol. 5, no. 24, pp. 3139–3147, Dec. 2016, doi: 10.1002/adhm.201600815.
C. P. Reis, N. Martinho, C. Rosado, A. S. Fernandes, and A. Roberto, “Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment,” Drug Dev. Ind. Pharm., vol. 40, no. 3, pp. 409–417, Mar. 2014, doi: 10.3109/03639045.2013.767826.
N. Srivastava, M. Choudhary, G. Singhal, and S. S. Bhagyawant, “SEM Studies of Saponin Silver Nanoparticles Isolated From Leaves of Chenopodium album L. for In Vitro Anti-acne Activity,” Proc. Natl. Acad. Sci. India Sect. B Biol. Sci., vol. 90, no. 2, pp. 333–341, Jun. 2020, doi: 10.1007/s40011-019-01100-1.
P. Sathishkumar et al., “Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract,” J. Photochem. Photobiol. B, vol. 163, pp. 69–76, Oct. 2016, doi: 10.1016/j.jphotobiol.2016.08.005.
H. Hidayat et al., “Antibacterial and photocatalytic activity of visible-light-induced synthesized gold nanoparticles by using Lantana camara flower extract,” Green Process. Synth., vol. 11, no. 1, pp. 1072–1082, Nov. 2022, doi: 10.1515/gps-2022-0091.
P. T. Huynh et al., “One-Pot, Surfactant-Free Synthesis of Gold Nanostars and Evaluation of Their Antibacterial Effects against Propionibacterium acnes,” J. Nanomater., vol. 2021, pp. 1–10, Mar. 2021, doi: 10.1155/2021/6650661.
N. Mahmoud, A. Alkilany, E. Khalil, and A. Al-Bakri, “Antibacterial activity of gold nanorods against Staphylococcus aureus and Propionibacterium acnes: misinterpretations and artifacts,” Int. J. Nanomedicine, vol. Volume 12, pp. 7311–7322, Oct. 2017, doi: 10.2147/IJN.S145531.
R. Goyal, L. K. Macri, H. M. Kaplan, and J. Kohn, “Nanoparticles and nanofibers for topical drug delivery,” J. Controlled Release, vol. 240, pp. 77–92, Oct. 2016, doi: 10.1016/j.jconrel.2015.10.049.
M. S. Adel Mehraban et al., “Effect of rose oil on Gastroesophageal Reflux Disease in comparison with omeprazole: A double-blind controlled trial,” Complement. Ther. Clin. Pract., vol. 43, no. March, p. 101361, 2021, doi: 10.1016/j.ctcp.2021.101361.
M. Jufri, M. Muthaharrah, E. Humairah, and E. H. Purwaningsih, “Stability of anti-acne niosome gels containing betel leaf (Piper betle L.) essential oil,” Int. J. Appl. Pharm., vol. 9, pp. 130–134, 2017, doi: 10.22159/ijap.2017.v9s1.72_79.
F. Tuğcu-Demiröz, S. Saar, A. A. Kara, A. Yıldız, E. Tunçel, and F. Acartürk, “Development and characterization of chitosan nanoparticles loaded nanofiber hybrid system for vaginal controlled release of benzydamine,” Eur. J. Pharm. Sci., vol. 161, no. March, 2021, doi: 10.1016/j.ejps.2021.105801.
S. Gurusamy et al., “Environmental friendly synthesis of TiO 2 -ZnO nanocomposite catalyst and silver nanomaterilas for the enhanced production of biodiesel from Ulva lactuca seaweed and potential antimicrobial properties against the microbial pathogens,” J. Photochem. Photobiol. B Biol., vol. 193, no. February, pp. 118–130, 2019, doi: 10.1016/j.jphotobiol.2019.02.011.
S. V. Sheen Mers, E. T. Deva Kumar, and V. Ganesh, “Gold nanoparticles-immobilized, hierarchically ordered, porous TiO2 nanotubes for biosensing of glutathione,” Int. J. Nanomedicine, vol. 10, pp. 171–182, 2015, doi: 10.2147/IJN.S80054.
P. T. Huynh et al., “One-Pot, Surfactant-Free Synthesis of Gold Nanostars and Evaluation of Their Antibacterial Effects against Propionibacterium acnes,” J. Nanomater., vol. 2021, 2021, doi: 10.1155/2021/6650661.
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