Pengaruh Metode Kokristalisasi Terhadap Laju Disolusi Asam Mefenamat Dengan Menggunakan Asam Sitrat Sebagai Koformer

Rizzqi Septiprajaamalia Rosdianto

Abstrak

Asam mefenamat merupakan obat antiinflamasi non steroid (AINS) yang memiliki kelarutan rendah dalam air, sehingga dapat mempengaruhi laju disolusinya. Kokristalisasi merupakan salah satu metode yang dapat meningkatkan kelarutan dan disolusi zat aktif melalui interaksi dengan koformer. Penelitian ini bertujuan untuk mengevaluasi pengaruh metode kokristalisasi terhadap laju disolusi asam mefenamat dengan menggunakan asam sitrat sebagai koformer. Kokristalisasi dilakukan dengan metode Liquid-Assisted Grinding (LAG) menggunakan etanol 96% sebagai pelarut. Karakterisasi hasil kokristal dilakukan menggunakan Fourier Transform Infrared (FTIR) untuk mengidentifikasi interaksi molekuler, Differential Scanning Calorimetry (DSC) untuk analisis termal, Powder X-Ray Diffraction (PXRD) untuk melihat perubahan kristalinitas, dan Scanning Electron Microscope (SEM) untuk mengamati morfologi partikel. Hasil karakterisasi menunjukkan adanya perubahan spektrum FTIR yang mengindikasikan pembentukan ikatan hidrogen antara asam mefenamat dan asam sitrat. Analisis DSC menunjukkan perubahan titik lebur, menandakan terbentuknya fase baru. Data PXRD mengungkapkan perubahan pola difraksi yang mengindikasikan munculnya perbedaan struktur kristalinitas dibandingkan dengan komponen murninya. Hasil SEM menunjukkan perubahan morfologi partikel yang lebih homogen dan berukuran lebih kecil. Uji disolusi menunjukkan bahwa KKAM 1:2 secara signifikan meningkatkan laju disolusi dibandingkan bentuk murninya. Dengan demikian, metode kokristalisasi menggunakan LAG dengan asam sitrat sebagai koformer terbukti efektif dalam meningkatkan laju disolusi asam mefenamat.

 

Kata Kunci

Asam mefenamat; asam sitrat; disolusi; kokristalisasi; Liquid-Assisted Grinding

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/mfarmasetika.v10i4.64634

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