Sistem Penghantaran Obat Oral dengan Tablet Lepas Lambat untuk Peningkatan Bioavailabilitas dan Efektivitas Terapi

Benni Iskandar, Ardihika Adinata, Aulia Siregar, Fauziah Nur Afifah, Fifi Suryani, Lathifa Calista Ramadhani, Muhammad Insankamil, Nurbaiti Jannah, Raysa Billa Rahmaliza, Siskha Agustina, Yesya Zahwalia, Zaskia Amelia Putri, Rodhia Ulfa

Abstrak

Sistem penghantaran obat oral dengan tablet lepas lambat (sustained-release) telah berkembang sebagai solusi untuk mengatasi keterbatasan sistem penghantaran obat konvensional, yang sering memerlukan dosis berulang dalam jangka waktu pendek. Tujuan penelitian ini adalah untuk mengeksplorasi berbagai aspek teknologi sustained-release, termasuk mekanisme pelepasan obat, jenis matriks polimer yang digunakan, serta dampaknya terhadap bioavailabilitas dan efektivitas terapi. Penelitian ini menggunakan pendekatan studi literatur, dengan memilih sepuluh artikel yang relevan dari basis data seperti ScienceDirect, PubMed, dan Google Scholar. Dari kajian terhadap 10 artikel menunjukkan bahwa sistem sustained-release dapat meningkatkan bioavailabilitas dengan mengontrol pelepasan obat secara stabil dan terkontrol. Penggunaan polimer seperti HPMC, Eudragit, dan Carbopol dalam formulasi tablet lepas lambat terbukti meningkatkan durasi efek terapeutik dan mengurangi frekuensi dosis, yang pada gilirannya meningkatkan kepatuhan pasien terhadap pengobatan. Stabilitas formulasi juga menjadi faktor penting, karena sistem ini membantu menjaga kualitas obat selama penyimpanan dan pemakaian. Meskipun banyak keuntungan yang dihasilkan, penelitian lebih lanjut diperlukan untuk mengoptimalkan formulasi dan teknik pemrosesan untuk mengatasi tantangan terkait efektivitas dan keamanan sistem ini.

 

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Referensi

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DOI: https://doi.org/10.24198/mfarmasetika.v11i5.71475

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