ANALISIS KADAR INTERLEUKIN- 8 PADA PERIODONTITIS AGRESIF

Abstract

Abstract

The etiopathogenesis of Aggressive Periodontitis based on clinical and histopathological study had been investigated abundantly. Nevertheless, the biomolecular mechanism especially in neutrophil chemotactic function were rarely studied. Interleukin-8 as chemoattractrant of neutrophil chemotactic which responsibility to host defense. The objective of this study was to examine and tho compare the level of IL-8 in aggressive periodontitis and non aggressive periodontitis patient. The research methode was case control study with consecutive sampling, consist of 32 aggressive periodontitis and 29 non aggressive periodontitis patient. The study was conducted during 20 months in Periodontic Clinic Rumah Sakit Gigi dan Mulut, Faculty of Dentistry, Padjadjaran University, Genetica Moleculer Medical Laboratory of Research Institution Padjadjaran University Bandung.The level of IL-8 of gingival crevicular fluid was asses by ELISA methode, The statistic analysis was chi-kuadrat test. The result showed that the average of the level IL-8 of aggressive periodontitis patient was 0,07053 (0,48761) pg/μl and non aggressive periodontitis was 0,12938(0,113063) pg/μl In conclusion the level of IL-8 of aggressive periodontitis significant lower than non aggressive periodontitis patient.

Key words: The level of IL-8, aggressive periodontitis, non aggressive periodontitis patient