Tinjauan Pustaka : Aktivitas Antioksidan In Vitro dari Kulit Buah Manggis (Garcinia mangostana L.)

Nabila Putri Azzahra, Raden Bayu Indradi

Abstrak


Abstrak

Antioksidan sebagai suatu zat yang pada konsentrasi rendah dapat menghambat proses stres oksidatif dari suatu subsrat yang dapat menetralkan efek reactive oxygen species (ROS) sehingga dapat mencegah berbagai penyakit. Jumlah antioksidan pada keadaan fisiologis normal seringkali tidak mencukupi untuk dapat menangkal radikal bebas, maka dari itu dibutuhkan tambahan asupan antioksidan. Salah satu sumber antioksidan alami dapat diperoleh dari kulit buah manggis (Garcinia mangostana L.). Telah banyak penelitian yang menunjukan aktivitas antioksidan dari kulit buah manggis menggunakan berbagai metode, sehingga tujuan dari review ini adalah untuk merangkum informasi dari penelitian-penelitian terkait yang telah dipublikasikan. Metode yang digunakan dalam penulisan artikel ini yaitu studi tinjauan pustaka (literauture review) dengan mencari kata kunci seperti antioksidan, Garcinia mangostana, metode in vitro dan lain-lain pada sumber basis data yaitu Pubmed, Google Scholar, dan Science Direct. Dari hasil tinjauan pustaka tersebut diperoleh berbagai senyawa bioaktif kulit buah manggis yang dievaluasi melalui berbagai metode pengujian in vitro serta beberapa faktor yang berpengaruh terhadap aktivitas antioksidan kulit buah manggis.


Teks Lengkap:

PDF

Referensi


Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: When to use the synthetic antioxidants. Oxidative Medicine and Cellular Longevity. 2013.

Shahidi F, Zhong Y. Measurement of antioxidant activity. Journal of Functional Foods. 2015.

Sindhi V, Gupta V, Sharma K, Bhatnagar S, Kumari R, Dhaka N. Potential applications of antioxidants – A review. J Pharm Res. 2013;

Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state. Nutrition Journal. 2016.

Boligon AA. Technical Evaluation of Antioxidant Activity. Med Chem (Los Angeles). 2014;

Tjahjani S, Widowati W, Khiong K, Suhendra A, Tjokropranoto R. Antioxidant Properties of Garcinia Mangostana L (Mangosteen) Rind. Procedia Chem. 2014;

Zhang X, Liu J, Yong H, Qin Y, Liu J, Jin C. Development of antioxidant and antimicrobial packaging films based on chitosan and mangosteen (Garcinia mangostana L.) rind powder. Int J Biol Macromol. 2020;

Li G, Thomas S, Johnson JJ. Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer. Frontiers in Pharmacology. 2013.

Widowati W, Fauziah N, Herdiman H, Afni M, Afifah E, Kusuma HSW, et al. Antioxidant and anti aging assays of Oryza sativa extracts, vanillin and coumaric acid. J Nat Remedies. 2016;

Zarena AS, Sankar KU. Phenolic acids, flavonoid profile and antioxidant activity in mangosteen (garcinia mangostana l.) pericarp. J Food Biochem. 2012;

Gondokesumo ME, Pardjianto B, Sumitro SB, Widowati W, Handono K. Xanthones analysis and antioxidant activity analysis (Applying ESR) of six different maturity levels of mangosteen rind extract (Garcinia mangostana Linn.). Pharmacogn J. 2019;

Jindarat S. Xanthones from mangosteen (Garcinia mangostana): Multi-targeting pharmacological properties. J Med Assoc Thail. 2014;

Siti Azima AM, Noriham A, Manshoor N. Anthocyanin content in relation to the antioxidant activity and colour properties of Garcinia mangostana peel, Syzigium cumini and Clitoria ternatea extracts. Int Food Res J. 2014;

Murugan R, Parimelazhagan T. Comparative evaluation of different extraction methods for antioxidant and anti-inflammatory properties from Osbeckia parvifolia Arn. - An in vitro approach. J King Saud Univ - Sci. 2014;

Wathoni N, Yuan Shan C, Yi Shan W, Rostinawati T, Indradi RB, Pratiwi R, et al. Characterization and antioxidant activity of pectin from Indonesian mangosteen (Garcinia mangostana L.) rind. Heliyon. 2019;

Iman Kamaludin NH, Mun LS, Sa’adi RA. Evaluation of antioxidant activity of some tropical fruit peel extracts: Extraction conditions optimization of rambutan peel extract. ARPN J Eng Appl Sci. 2016;

Indrianingsih AW, Rosyida VT, Ratih D, Batrisya. In Vitro Study of Antioxidant and Antimicrobial Activities of Garcinia mangostana L. Peel Extract. In 2020.

Sugita P, Arya S, Ilmiawati A, Arifin B. Characterization, antibacterial and antioxidant activity of mangosteen (Garcinia mangostana L.) pericarp nanosized extract. Rasayan J Chem. 2017;

Manasathien J, Khanema P. Antioxidant and cytotoxic activities of mangosteen garcinia mangostana pericarp extracts. Asia-Pacific J Sci Technol. 2015;

Samuagam L, Cm S, Ga A, Pn O, Hs Y. The Effect of Extraction Conditions on Total Phenolic Content and Free Radical Scavenging Capacity of Selected Tropical Fruits’ Peel. Heal Environ J. 2013;

Wittenauer J, Schweiggert-Weisz U, Carle R. In vitro-study of antioxidant extracts from Garcinia mangostana pericarp and Riesling grape pomace - a contribution to by-products valorization as cosmetic ingredients. J Appl Bot Food Qual. 2016;

Widowati W, Darsono L, Suherman J, Yelliantty Y, Maesaroh M. High Performance Liquid Chromatography (HPLC) Analysis, Antioxidant, Antiaggregation of Mangosteen Peel Extract (Garcinia mangostana L.). Int J Biosci Biochem Bioinforma. 2014;

Geetha S, Saraswathi K, Chakrapani GD, Sivaraj C, Dhivya M. Antioxidant and anticancer activities of pericarp of Garcinia mangostana L . 2020;9(4):1805–9.

Ghasemzadeh A, Jaafar HZE, Baghdadi A, Tayebi-Meigooni A. Alpha-mangostin-rich extracts from mangosteen pericarp: Optimization of green extraction protocol and evaluation of biological activity. Molecules. 2018;

Sukatta U, Takenaka M, Ono H, Okadome H, Sotome I, Nanayama K, et al. Distribution of major xanthones in the pericarp, aril, and yellow gum of mangosteen (garcinia mangostana Linn.) fruit and their contribution to antioxidative activity. Biosci Biotechnol Biochem. 2013;

Sungpud C, Panpipat W, Sae-Yoon A, Chaijan M. Polyphenol extraction from mangosteen (Garcinia mangostana Linn) pericarp by bio-based solvents. Int Food Res J. 2020;

Shekhar TC, Anju G. Antioxidant Activity byDPPH Radical Scavenging Method of Ageratum conyzoides Linn. Leaves. Am J Ethnomedicine. 2014;

Widiyarti G, Supiani S, Tiara Y. Antioxidant Activity and Toxicity of Puspa (Schima wallichii) Leaves Extract from Indonesia. J Trop Life Sci. 2018;

Diantini A, Subarnas A, Lestari K, Halimah E, Susilawati Y, Supriyatna, et al. Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. Oncol Lett. 2012;

Ro J, Kim Y, Kim H, Jang SB, Lee HJ, Chakma S, et al. Anti-oxidative activity of pectin and its stabilizing effect on retinyl palmitate. Korean J Physiol Pharmacol. 2013;

Kusmayadi A, Adriani L, Abun A, Muchtaridi M, Tanuwiria UH. Antioxidant activity of mangosteen peel (Garcinia mangostana L.) extracted using different solvents at the different times. Drug Invent Today. 2019;

Dong JW, Cai L, Xing Y, Yu J, Ding ZT. Re-evaluation of ABTS·G+ assay for total antioxidant capacity of natural products. Nat Prod Commun. 2015;

Martínez A, Hernández-Marin E, Galano A. Xanthones as antioxidants: A theoretical study on the thermodynamics and kinetics of the single electron transfer mechanism. Food Funct. 2012;

Sherikar A, Mahanthesh M. Evaluation of aqueous and methanolic extract of leaves of Epipremnum aureum for radical scavenging activity by DPPH Method, total phenolic content, reducing capacity assay and FRAP assay. J Pharmacogn Phytochem JPP. 2015;

García-Santamarina S, Boronat S, Hidalgo E. Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction. Biochemistry. 2014;

Mukhopadhyay D, Dasgupta P, Sinha Roy D, Palchoudhuri S, Chatterjee I, Ali S, et al. A Sensitive In vitro Spectrophotometric Hydrogen Peroxide Scavenging Assay using 1,10-Phenanthroline. Free Radicals Antioxidants. 2016;

Dungir SG, Katja DG, Kamu VS. Aktivitas Antioksidan Ekstrak Fenolik dari Kulit Buah Manggis (Garcinia mangostana L.). J MIPA. 2012;

Kusmayadi A, Adriani L, Abun A, Muchtaridi M, Tanuwiria UH. The effect of solvents and extraction time on total xanthone and antioxidant yields of mangosteen peel (Garcinia mangostana L.) extract. Drug Invent Today. 2018.

Suttirak W, Manurakchinakorn S. In vitro antioxidant properties of mangosteen peel extract. Journal of Food Science and Technology. 2014.

Manurakchinakorn S, Chainarong Y, Sawatpadungkit C. Quality of mangosteen juice colored with mangosteen pericarp. Int Food Res J. 2016.

Ibrahim UK, Austin EA, Mohd Salleh R. Effect of Drying Temperature and Time on Antioxidant and Total Phenolic Content in Garcinia mangostana Pericarp. Adv Mater Res. 2015.

Chaovanalikit A, Mingmuang A, Kitbunluewit T, Choldumrongkool N, Sondee J, Chupratum S. Anthocyanin and total phenolics content of mangosteen and effect of processing on the quality of Mangosteen products. Int Food Res J. 2012.

Setyawati DM, Mardliyati E, Rahman S, Wijaya AF. Spray drying of mangosteen (Garcinia mangostana L.) juice and analysis of antioxidant activity and total phenolic content. In: IOP Conference Series: Materials Science and Engineering. 2020.

Sagrin MS, Chong GH. Effects of drying temperature on the chemical and physical properties of Musa acuminata Colla (AAA Group) leaves. Ind Crops Prod. 2013.

Sie JO. Daya Antioksidan Ekstrak etanol kulit buah manggis (Garcinia mangostana Linn.) Hasil Pengadukan dan Reflux. J Ilm Mhs Univ Surabaya. 2013.




DOI: https://doi.org/10.24198/ijbp.v1i2.37404

DOI (PDF): https://doi.org/10.24198/ijbp.v1i2.37404.g16945

Refbacks

  • Saat ini tidak ada refbacks.


##submission.license.cc.by-nc4.footer##

IJBP by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License