Effect of Combination Herbal Plants Extracts on Diabetes Mellitus
Abstrak
Diabetes is a non-communicable disease with metabolic dysfunction characterized by high glucose levels due to damage to pancreatic β cells so that insulin cannot be secreted normally by the body. Diabetes mellitus cannot be cured, but it can only be controlled with appropriate treatment. Most of the available synthetic antidiabetic treatments have serious side effects and are quite expensive. Therefore, traditional herbal medicine is an alternative which is used for some people in maintaining normal blood sugar levels. The use of herbal therapy with a combination of plant extracts has the potential to be more effective in lowering blood sugar when compared to single plant extracts. The aim of this article review is that to compile and provide a scientific overview of the various studies which have been conducted previously regarding the effectiveness of combinations of herbal plant extracts in diabetes mellitus. A comprehensive literature study was conducted by using various electronic search databases with the keyword “Combination of antidiabetic extracts” and 30 international research journals which were combined into review articles were obtained which shows that combinations of plant extracts proved to be more effective in lowering blood glucose levels compared to single herbal plant extracts.
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American Diabetes Association Professional Practice Committee and American Diabetes Association Professional Practice Committee., 2022. Diabetes technology: standards of medical care in diabetes—2022, Vol. 45, pp.S97-S112.
Rahman, M.S., Hossain, K.S., Das, S., Kundu, S., Adegoke, E.O., Rahman, M.A., Hannan, M.A., Uddin, M.J. and Pang, M.G., 2021. Role of insulin in health and disease: an update. International journal of molecular sciences, 22(12), p.6403.
Vasiljević, J., Torkko, J.M., Knoch, K.P. and Solimena, M., 2020. The making of insulin in health and disease. Diabetologia, 63, pp.1981-1989.
Giri, B., Dey, S., Das, T., Sarkar, M., Banerjee, J. and Dash, S.K., 2018. Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: an update on glucose toxicity. Biomedicine & pharmacotherapy, 107, pp.306-328.
Accili, D., 2018. Insulin action research and the future of diabetes treatment: the 2017 banting medal for scientific achievement lecture. Diabetes, 67(9), pp.1701-1709.
Center for Disease Control and Prevention, 2023. Diabetes. Retrieved https://www.cdc.gov/diabetes/basics/diabetes.html
International Diabetes Federation, 2019. Diabetes Atlas 9th Edition 2019. Retrieved from https://diabetesatlas.org/atlas/ninth-edition/
Nagesh, M.R., Vijayakumar, N. and Bhavani, K., 2020. A review on diabetes mellitus-an annihilatory metabolic disorder. Journal of Pharmaceutical Sciences and Research, 12(2), pp.232-235.
Sivakumar, T. and Deepa, B., 2023. A critical review on Antidiabetic Potential of Herbal plants and its their bioactive components. J Univer Shanghai Sci Tech, 25(01), pp.303-314.
Gupta, R.C., Chang, D., Nammi, S., Bensoussan, A., Bilinski, K. and Roufogalis, B.D., 2017. Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications. Diabetology & metabolic syndrome, 9(1), pp.1-12
Alipin, K., Istiqamah, N. and Maryani, A., Madihah. 2019. The Potential of Combined Curcuma xanthorrhiza Rhizome and Averrhoa bilimbi Fruit Extract on Decreasing Blood Glucose Levels, Insulitis Degree and Liver Structure Repair of Diabetic Male Wistar Rats Streptozotocin-Induced. Journal of Diabetes and Metabolism, 10(835), pp.1-7.
Widharna, R.M., Tamayanti, W.D., Hendriati, L., Hamid, I.S. and Widjajakusuma, E.C., 2015. Antidiabetic effect of the aqueous extract mixture of Andrographis paniculata and Syzygium polyanthum leaf. European Journal of Medicinal Plants, 6(2), p.82.
Masaenah, E., Elya, B., Setiawan, H., Fadhilah, Z., Wediasari, F., Nugroho, G.A., Elfahmi, Mozef, T. 2021. Antidiabetic activity and acute toxicity of combined extract of Andrographis paniculata, Syzygium cumini, and Caesalpinia sappan. Heliyon, 7(12), e08561.
Kaur, G., Invally, M., Khan, M.K. and Jadhav, P., 2018. A nutraceutical combination of Cinnamomum cassia & Nigella sativa for Type 1 diabetes mellitus. Journal of Ayurveda and integrative medicine, 9(1), pp.27-37.
Fitrawan, Ariastuti, R., Tjandrawinata, R.R., Nugroho, A.E., Pramono, S. 2018. Antidiabetic effect of combination of fractionated-extracts of Andrographis paniculata and Centella asiatica: In vitro study. Asian Pacific Journal of Tropical Biomedicine, 8(11), p.527-532
Deepa, J., Aleykutty, N.A., Jyoti, H. 2018. Effect of Combination of Two Plant Extracts on Diabetes Mellitus. International Journal of Pharmacy and Pharmaceutical Sciences, 10(4), p. 49-52
Perumal, N., Nallappan, M., Shohaimi, S., Kassim, N.K., Tee, T.T. and Cheah, Y.H., 2022. Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex FH Wigg and Momordica charantia L. polyherbal combination. Biomedicine & Pharmacotherapy, 145, p.112401.
Kusumawati, I.G.A.W., Atikawati, Putra, I.M.W., Yogeswara, I.B.A. 2022. Antioxidant activity and α-amylase inhibitory of herbal drink from the combination of Blumea balsamifera L and Coccinia grandis L. Food Research, 6(4), p. 329 – 336
Aligita, W.I.D.H.Y.A., Kurniati, N.F. and Sukandar, E.Y., 2016. Antidiabetic study of combination of Andrographis paniculata (Burm. F.) Wallich. Ex Ness. Herbs extract and Guazuma ulmifolia Lamk. Leaves extract in obese diabetic mice model. Int J Pharm Pharm Sci, 8(1), pp.316-20.
Shokri, G., Fathi, H., Jafari Sabet, M., Nasri Nasrabadi, N. and Ataee, R., 2015. Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats. Pharmaceutical and Biomedical Research, 1(2), pp.20-29.
Naim, A., Trisna, M., Marjoni, M.R. 2018. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. National Journal of Physiology, Pharmacy and Pharmacology, 8(10), pp. 1446-1450.
Efiong, E.E., Igile, G.O., Mgbeje, B.I.A., Out, E.A. and Ebong, P.E., 2013. Hepatoprotective and anti-diabetic effect of combined extracts of Moringa oleifera and Vernonia amygdalina in streptozotocin-induced diabetic albino Wistar rats. Journal of Diabetes and Endocrinology, 4(4), pp.45-50.
Otunola, G.A. dan Afolayan, A.J. 2015. Antidiabetic effect of combined spices of Allium sativum, Zingiber officinale and Capsicum frutescens in alloxan-induced diabetic rats. Frontiers in Life Science, 8(4), 314-323,
Savych, A., Gerush, O. and Basaraba, R., 2021. Determinationof hypoglycemic activity of the herbal mixtures by means of glucose loading tests (message 3). PharmacologyOnLine, 2, pp.1128-1137.
Nivedha, V.M., Priyadarshini, R., Rajeshkumar, S., dan Sinduja, P. 2021. Anti-diabetic and Antioxidant Activity of Pterocarpus santalinus and Stevia Herbal Formulation. Journal of Pharmaceutical Research International, 33(62B), 124-134.
Bello, O.I., Ayoola, M.D., Obembe, O., Akinwunmi, K.F. 2022. Antidiabetic and Toxicity Studies of the Extract of Four Nigerian Medicinal Plants. European Journal of Medicinal Plants, 33(11), pp.32-45.
Savych, A. and Sinichenko, A., 2021. Screening study of hypoglycemic activity of the herbal mixtures used in folk medicine (message 4). PharmacologyOnLine, 2, pp.1254-1262.
Savych, A., Roksolana, B., and Oleg, G. 2021. Comparative Analysis of Hypoglycemic Activity of Herbal Mixtures by Glucose Tolerance Tests (Message 2). PharmacologyOnLine, 2, pp.1118-1127.
Savych, A. and Polonets, O., 2021. Study of hypoglycemic activity of antidiabetic herbal mixture on streptozotocin-nicotinamideinduced rat model of type 2 diabetes. PharmacologyOnLine, 2, pp.62-67.
Sotoudeh R, Hadjzadeh MA, Gholamnezhad Z, Aghaei A. 2019. The anti-diabetic and antioxidant effects of a combination of Commiphora mukul, Commiphora myrrha and Terminalia chebula in diabetic rats. Avicenna J Phytomed, 9(5), p.454-464.
Bastian, F., Chandra, M., Langkong, J., Elsa, S. and Winters, J.F., 2023, May. Combination of Gedi leaves (Abelmoschus Manihot L.) extract and arabica coffee (Coffea arabica L.) in making herbal coffee as an alternative therapy for diabetes mellitus. In AIP Conference Proceedings (Vol. 2596, No. 1). AIP Publishing.
Sunaryo, H., Hikmawanti, N.P.E. and Listyaningrum, H.A., 2018, August. Study in Activity Combination of Physalis Angulata and Hibiscus sabdariffa in 70% Ethanol Extract to Decrease Blood Sugar Levels and Histopathology of Pancreas Langerhans Island in Alloxan Induced Diabetic Rats. In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018) (pp. 117-122).
Berawi, K.N., Shidarti, L., Nurdin, S.U., Lipoeto, N.I. and Wahid, I., 2017. Comparison effectiveness of antidiabetic activity extract herbal mixture of soursop leaves (annona muricata), bay leaves (syzygium polyanthum) and pegagan leaves (centella asiatica). Biomedical and Pharmacology Journal, 10(3), pp.1481-1488.
Teugwa, C.M., Mejiato, P.C., Zofou, D., Tchinda, B.T. and Boyom, F.F., 2013. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae). BMC complementary and alternative medicine, 13, pp.1-9.
Okokon, J.E., Umoh, U.F., Ekpo, B.A.J., Etim, E.I. 2013. Antidiabetic study of combined extracts of Vernonia amygdalina, Ocimum gratissimum, and Gongronema latifolium on alloxan induced diabetic rats. Journal of Natural Pharmaceuticals, 4(1), pp.28-31.
Abdulazeez Mansurah, A., Kassim, I., Kenpia, B., Babvoshia Hope, B. and Abdullahi, Y., 2013. Effect of combined use of Ocimum gratissimum and Vernonia amygdalina extract on the activity of angiotensin converting enzyme, hypolipidemic and antioxidant parameters in streptozotocin-induced diabetic rats. African journal of biochemistry research, 7(9), pp.165-173.
El-Amin, M., Virk, P., Elobeid, M.A., Almarhoon, Z.M., Hassan, Z.K., Omer, S.A., Merghani, N.M., Daghestani, M.H. and Al-Olayan, E.M., 2013. Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats. Pak J Pharm Sci, 26(2), pp.359-65.
Sharma, A.K. and Gupta, R. 2017. Anti-Hyperglycemic Activity of Aqueous Extracts of Some Medicinal Plants on Wistar Rats. Journal of Diabetes and Metabolism, 8(7), pp. 1-7.
Borikar, S.P., Kallewar, N.G., Mahapatra, D.K., Dumore, N.G. 2018. Dried flower powder combination of Clitoria ternatea and Punica granatum demonstrated analogous anti-hyperglycemic potential as compared with standard drug metformin: In vivo study in Sprague Dawley rats. Journal of Applied Pharmaceutical Science, 8(11), pp. 075-079.
Kiani, Z., Hassanpour-Fard, M., Asghari, Z., Hosseini, M.. 2020. Experimental evaluation of a polyherbal formulation (Tetraherbs): antidiabetic efficacy in rats. Comp Clin Patho, pp. 1437–1445.
DOI: https://doi.org/10.24198/ijbp.v3i3.47737
DOI (PDF): https://doi.org/10.24198/ijbp.v3i3.47737.g22264
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