Role of Herbal Plants on Autophagy
Abstract
Autophagy is a biomolecular system known to play an important role in cell growth, development as well as defense mechanisms, and is also a physiological approach towards homeostasis maintenance. This phenomenon is an intermediary pathway in the pathogenesis and therapy of various disease types, and is currently a new treatment route in the medical world. Hence, it is necessary to deeply understand the regulations, to prepare a treatment strategy in the future. Conversely, there is a high utilization of drugs, in line with the numerous disease cases in the community. Some limited chemical forms have large but necessary side effects, including anticancer agents. The high incidence of resistance and polypharmacy has been implicated in adverse drug interactions, and exorbitant costs, thus the initiative to return back to natural means. Furthermore, herbal medicines have been used in treatments for thousands of years, prior to the discovery of modern medicine. The various types previously studied have been highly beneficial in various disease cases. This review on researches within the last 5 years identified some herbal research articles in the aspect of autophagy, which was then summarized in a table form. Meanwhile, autophagy has been used for cancer therapy, and many plants have the potential to be therapeutic for various diseases through this pathway. Hence, improving related knowledge adds a new dimension to herbal medicine application in the pharmaceutical industry.
Keywords: Autophagy, herbal, cancer, metabolic diseases, liver injury, neurological disorder
Peran Berbagai Tanaman Herbal pada Autofagi
Abstrak
Autofagi adalah sistem biomolekuler sel yang berperan penting dalam pertumbuhan sel, perkembangan dan mekanisme pertahanan, dan merupakan sebuah cara fisiologis untuk mempertahankan homeostasis. Autofagi digunakan sebagai jalur perantara untuk patogenesis dan terapi berbagai jenis penyakit, dan saat ini autofagi telah menjadi jalan pengobatan baru di dunia medis sehingga regulasi jalur autofagi harus dipelajari lebih dalam untuk mempersiapkan strategi pengobatan di masa depan. Di sisi lain, tingginya pemanfaatan obat-obatan sejalan dengan banyaknya kasus penyakit yang muncul di masyarakat. Beberapa obat kimia memiliki efek samping yang besar tetapi jumlahnya terbatas, misalnya pada obat antikanker. Selain itu, tingginya kasus resistensi obat dan polifarmasi menyebabkan interaksi obat yang merugikan dan biaya obat yang tinggi. Oleh karena itu, pengobatan kini telah kembali ke alam. Herbal telah digunakan sebagai pengobatan selama ribuan tahun sebelum pengobatan modern ditemukan. Berbagai jenis herbal telah dipelajari dan memiliki manfaat yang baik dalam berbagai kasus penyakit di masyarakat. Pada artikel review ini, ditelaah artikel-artikel penelitian herbal yang mengambil jalur autofagi dan hasilnya dirangkum dalam bentuk tabel. Studi yang dilakukan dalam kurun waktu 5 tahun terakhir dimasukkan dalam review ini. Sampai sekarang, autofagi telah lebih banyak digunakan untuk terapi kanker dibandingkan yang tanpa kanker. Banyak tanaman herbal yang memiliki potensi untuk menjadi terapi berbagai jenis penyakit melalui jalur autofagi. Pengetahuan tentang autofagi menambah dimensi baru pada pengobatan herbal dan dapat diterapkan dalam industri farmasi.
Kata kunci: Autofagi, gangguan metabolisme, gangguan saraf, herbal, kanker, kerusakan hati
Keywords
References
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. Dynamics and diversity in autophagymechanisms: Lessons from yeast. Nat Rev Mol Cell Biol. 2009;10:458–68. doi: 10.1038/nrm2708
Sedwick C. Yoshinori Ohsumi: Autophagy from beginning to end. J Cell Biol. 2012;197(2):164–5. doi: 10.1083/jcb.1972pi
Nakatogawa H, Ishii J, Asai E, Ohsumi Y. Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Autophagy. 2012;8(2):177–86. doi: 10.4161/auto.8.2.18373
Jiao J, Demontis F. Skeletal muscle autophagy and its role in sarcopenia and organismal aging. Curr Opin Pharmacol. 2017;34:1–6. doi: 10.1016/j.coph.2017.03.009
Glick D, Barth S, Macleod K.F. Autophagy: Cellular and molecular mechanisms. J Pathol. 2010;221(1):3–12. doi: 10.1002/path.2697
Sharma N, Thomas S, Golden EB, Hofman FM, Chen TC, Petasis NA, et al. Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalaria agent. Cancer Lett. 2012:326(2):143–54. doi: 10.1016/j.canlet.2012.07.029
Morselli E, Galluzzi L, Kepp O, Vicencio JM, Crriollo A, Maiuri MC, et al. Anti- and pro-tumor functions of autophagy. Biochim Biophys Acta. 2009;1793(9):1524–32. doi: 10.1016/j.bbamcr.2009.01.006
Sala-Cirtog M, Marian C, Anghel A. New insights of medicinal plant therapeutic activity—The miRNA transfer. Biomed Pharmacother. 2015;74:228–32. doi: 10.1016/j.biopha.2015.08.016
Liu C, Liao JZ, Li PY. Traditional chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. World J Gastroenterol. 2017;23(11):1964–73. doi: 10.3748/wjg.v23.i11.1964
Zou N, Wei Y, Li F, Yang Y, Cheng X, Wang C. The inhibitory effects of compound Muniziqi granule against B16 cells and harmine induced autophagy and apoptosis by inhibiting Akt/mTOR pathway. BMC Complement Altern Med. 2017;17(1):517–23. doi: 10.1186/s12906-017-2017-4
Huang Z, Ye B, Dai Z, Wu X, Lu Z, Shan P, et al. Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes. Mol Med Rep. 2015;11(6):4678–84. doi: 10.3892/mmr.2015.3322
Jin HR, Du CH, Wang CZ, Yuan CS, Du W. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death. Phytother Res. 2019;33(3):610–7. doi: 10.1002/ptr.6249
Liu YH, Weng YP, Tsai HY, Chen CJ, Lee DY, Hsieh CL, et al. Aqueous extracts of paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells. Phytomedicine. 2018;46:184–92. doi: 10. 1016/j.phymed.2018.03.037
Qin Y, Zhang Y, Tomic I, Hao W, Menger MD, Liu C, et al. Ginkgo biloba extract egb 761 and its specific components elicit protective protein clearance through the autophagy-lysosomal pathway in tau-transgenic mice and cultured neurons. J Alzheimers Dis. 2018;65(1):243–63. doi: 10.3233/JAD-180426
Lan YL, Zhou JJ, Liu J, Huo XK, Wang YL, Liang JH, et al. Uncaria rhynchophylla ameliorates parkinson’s disease by inhibiting hsp90 expression: Insights from quantitative proteomics. Cell Physiol Biochem. 2018;47(4):1453–64. doi: 10.1159/000490837
Li H, Zhang Y, Min J, Gao L, Zhang R, Yang Y. Astragaloside IV attenuates orbital inflammation in graves’ orbitopathy through suppression of autophagy. Inflamm Res. 2018;67(2):117–27. doi: 10. 1007/s00011-017-1100-0
Wang D, Yu W, Liu Y, Zhong G, Zhao Z, Yan X, et al. Roles of autophagy in ischemic heart diseases and the modulatory effects of chinese herbal medicine. Am J Chin Med. 2017;45(7):1401–19. doi: 10.1142/S0192415X17500768
Wong VKW, Zeng W, Chen J, Yao XJ, Leung ELH, Wang QQ, et al. Tetrandrine, an activator of autophagy, induces autophagic cell death via PKC-α inhibition and mTOR-dependent mechanisms. Front Pharmacol. 2017;8:351–4. doi: 10.3389/fphar.2017.00351
Cao ZX, Yang YT, Yu S, Li YZ, Wang WW, Huang J, et al. Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells. J Ethnopharmacol. 2017;202:20–7. doi: 10. 1016/j.jep.2016.07.028
Tang ZH, Chen X, Wang ZY, Chai K, Wang YF, Xu XH, et al. Induction of C/EBP homologous protein-mediated apoptosis and autophagy by Licochalcone A in non-small cell lung cancer cells. Sci Rep. 2016;6:262241. doi: 10.1038/srep26241
Liang Y, Zhu J, Huang H, Xiang D, Li Y, Zhang D, et al. SESN2/Sestrin 2 induction-mediated autophagy and inhibitory effect of Isorhapontigenin (ISO) on human bladder cancers. Autophagy. 2016;12(8):1229–39. doi: 10.1080/15548627.2016.1179403
Pratiwi YS, Lesmana R, Goenawan H, Sylviana N, Setiawan I, Tarawan VM, et al. Nutmeg extract increases skeletal muscle mass in aging rats partly via IGF1-AKT-mTOR pathway and inhibition of autophagy. Hindawi. Evid Based Complementary Altern Med. 2018:2810840. doi: 10.1155/2018/2810840
Zhang QR, Zhong ZF, Sang W, Xiong W, Tao HX, Zhao GD, et al. Comparative comprehension on the anti-rheumatic chinese herbal medicine Siegesbeckiae Herba: combined computational predictions and experimental investigations. J Ethnopharmacol. 2019;228:200–9. doi: 10. 1016/j.jep.2018.09.023
Dai, Y, Hu S. Recent insights into the role of autophagy in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford). 2016;55(3):403–10. doi: 10.1093/rheumatology/kev337
Utaipan T, Athipornchai A, Suksamrarn A, Jirachotikoon C, Yuan X, Lertcanawanichakul M, et al. Carbazole alkaloids from Murraya koenigii trigger apoptosis and autophagic flux inhibition in human oral squamous cell carcinoma cells. J Nat Med. 2017;71(1):158–69. doi: 10.1007/s11418-016-1045-6
Wu PF, Chiu CC, Chen CY, Wang HM. 7-Hydroxydehydronuciferine induces human melanoma death via triggering autophagy and apoptosis. Exp Dermatol. 2015;24(12):930–5. doi: 10.1111/exd.12805
Wang Li, Li MD, Cao PP, Zhang CF, Huang F, Xu XH, et al. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014;223: 1–9. doi: 10.1016/j.cbi.2014.09.003
Law BY, Mo JF, Wong VK. Autophagic effects of Chaihu (dried roots of Bupleurum Chinense DC or Bupleurum Scorzoneraefolium WILD). Chin Med. 2014;11(9):21–9. doi: 10.1186/1749-854 6-9-21
DOI: https://doi.org/10.15416/ijcp.2020.9.2.179
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