Isolation and Phisicochemical Characterization of Microcristalline Cellulose from Ramie (Boehmeria nivea L. Gaud) Based on Pharmaceutical Grade Quality

Desy Nawangsari; Anis Yohana Chaerunisaa; Marline Abdassah; Sriwidodo Sriwidodo; Taofik Rusdiana; Linda Apriyanti

doi:10.24198/ijpst.v5i2.15040

Isolation and Phisicochemical Characterization of Microcristalline Cellulose from Ramie (Boehmeria nivea L. Gaud) Based on Pharmaceutical Grade Quality

Desy Nawangsari, Anis Yohana Chaerunisaa, Marline Abdassah, Sriwidodo Sriwidodo, Taofik Rusdiana, Linda Apriyanti

Abstrak

Microcrystalline cellulose is the most used material for medicine, which able to be found in fibrous plants. Microcrystal celluloses are being used as filler or binder in dosage formulas in tablets and capsules. This research aimed to produce microcrystalline cellulose from ramie based on pharmaceutical grade parameters. Research method include hemp fiber preparation, α-cellulose isolation, microcrystalline cellulose production, and microcrystalline cellulose characterization which compare with Avicel^® PH 102 . Result shown microcrystalline cellulose yield is 57.26%. The result of physicochemical characterization that can comply the specifications of pharmaceutical grade as a pharmaceutical excipient.

Keywods : Microcrystalline cellulose, Ramie, physicochemical, pharmaceutical grade.

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Referensi

Anonim. United States Pharmacopeia and The National Formulary, Rockville (MD), The United States Pharmacopeial Convention; 2009.

Apriyanti, Linda. Pengaruh Proses Pengeringan Terhadap Kualitas Selulosa Mikrokristal dari Rami (Boehmeria nivea L. Gaud.) sebagai eksipien farmasi dengan kualitas pharmaceutical grade (skripsi). Bandung : Universitas Padjadjaran; 2017.

Azubuike C.P. dan Okhamafe A.O. Physicochemical, spectroscopic, and thermal properties of microcrystalline cellulose derivied from corn crobs. Int Journal Recycling of Org Waste Agric. 2012; 1(9): 1 – 7.

Behin, J., Mikaniki, F., dan Fadaei, Z. Dissolving Pulp (alpha-cellulose) from Corn Stalk by Kraft Process, Iranian Journal of Chemical Engineering. 2008; 5 (3): 14-28.

Ben, E.S. Teknologi Tablet. Padang. Andalas University Press; 2008.

Department of Health and Human Services US. The United States Pharmacopoeia, Thirtieth Revision-The National Formulary, Twenty-Fifth Edition. Rockville, Maryland: United States Pharmacopoeial Convention, Inc; 2008.

Hamisan, A. F., Abd-Aziz dan Kamaruddin: Delignification of oil palm empty fruit bunch using chemical and microbial pretreatment methods, International Journal of Agricultural Research, 2009; 4 (8): 250–256

DOI: https://doi.org/10.24198/ijpst.v5i2.15040