Indonesian Journal of Pharmaceutical Science and Technology
Activity Assay of Etanol Ectract of Lansau As Antihyperlipidemic
Abstrak
Hyperlipidemia is a condition due to increased levels of total cholesterol such as triglycerides, Low Density Lipoprotein (LDL) and decreased levels of High Density Lipoprotein (HDL). Hyperlipidemia can trigger wall thickening and narrowing of arteries, this condition can cause abnormality of fat metabolism in the blood and creates chronic disease. Lansau herb of the Muna tribe of Southeast Sulawesi consists of 44 ingredients of medicinal plants empirically used to treat various diseases such as koleseterol. The aim of this study was to determine the effect of ethanolic extract to the hispatology of the liver that had hyperlipidemia. The parameters are fatty cell and necrosis forming. Mice were induced by cholesterol and high-fat feed. 24 wistar rats were divided into 6 groups consisting of normal control (1% Na CMC), cholesterol and high fat diet food induction control, positive control (simvastatin 0.4 mg / kgbw), group 1 (dose 6.907 mg / kgbw) group II (dose 13.814 mg /kgbw), group III (dose 27.628 mg/kgbw). After 14 days of treatment, hispatological datas of liver were observed. The results showed that the ethanol extract of lansau had the potential activity as antihyperlipidemia, and cell repairing, especially in administering doses of 27.628 mg/kgbw and had effectiveness that was not much different from the administration of simvastatin in reducing fat degeneration and cell death.
Key word : Aterosclerosis, hyperlipidemic, Lansau, simvastatin.
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Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik; 2014 2 (2).
Rachmawati Syukur, Gemini Alam, Mufidah, Abdul Rahim, R. T., Aktivitas antiradikal bebas bebas beberapa ekstrak tanaman familia fabacea. Journal of Chemical Information and Modeling, 2013; 53(9), 1689-1699
Gilman, Goodman and Gilman: Dasar farmakologi terapi. Jakarta: EGC, 2012; Edisi 10. Vol 2,.
Ruslin, Henny K, Sunandar I, Suryani, Nur Samsiar, Ardiyanti, Zulfikar T, Rahmat D, Elsa, The identification of pharmacognostic on the extraction of tradisional medicine to lansau of Muna ethnic of Southeast Sulawesi Province. IAJPS 2017; 4 (11), 4170-4177
Elfrida, E., , Efek Antihiperlipidemia ekstrak etanol 70% buah parijoto (Medinilla speciosa Blume) terhadap jaringan hati tikus putih jantan, 2015; UIN Syarif Hidayatullah, Jakarta.
Swarayana, I.M.I., I Wayan, S., dan I Ketut, B., Perubahan histopatologi hati mencit (Mus musculus) yang diberikan ekstrak daun ashitaba (Angelica keiskei), Buletin Veteriner Udayana. 2012; 4 (2).
Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta Tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik. 2014; 2 (2).
Dimas, A. P., Rahmah, F. S dan Setyaningrum, T. R., Potensi antihiperlipidemia ekstrak etanol daun bayam merah (Amaranthus tricolor L.) terstandar secara in vivo berdasarkan parameter LDL (Low Density Lipoprotein), Jurnal Sains Farmasi & Klinis. 2016; 2(2).
Kamesh, V., and Thangarajan, S., Antihypercholesterolemic effect of bacopa monniera linn on high cholesterol diet induced hypercholesterolemia in rats, Asian Pasific Journal Of Tropical Medicine. 2012
Umarudin, S., dan Yuniastuti, A., Efektivitas ekstrak tanin seledri terhadap profil hiperkolesterolemi lipid tikus putih, Jurusan Biologi FMIPA Universitas Negeri Semarang Indonesia, Unnes Journal of Life Science. 2012
Desi Sartina. Pengaruh ektraksi etanol lansau terhadap histopatologi organ hati tikus putih wistar jantan yang mengalami hiperlipidemia. Skripsi UHO; 2018
Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik; 2014 2 (2).
Rachmawati Syukur, Gemini Alam, Mufidah, Abdul Rahim, R. T., Aktivitas antiradikal bebas bebas beberapa ekstrak tanaman familia fabacea. Journal of Chemical Information and Modeling, 2013; 53(9), 1689-1699
Gilman, Goodman and Gilman: Dasar farmakologi terapi. Jakarta: EGC, 2012; Edisi 10. Vol 2,.
Ruslin, Henny K, Sunandar I, Suryani, Nur Samsiar, Ardiyanti, Zulfikar T, Rahmat D, Elsa, The identification of pharmacognostic on the extraction of tradisional medicine to lansau of Muna ethnic of Southeast Sulawesi Province. IAJPS 2017; 4 (11), 4170-4177
Elfrida, E., , Efek Antihiperlipidemia ekstrak etanol 70% buah parijoto (Medinilla speciosa Blume) terhadap jaringan hati tikus putih jantan, 2015; UIN Syarif Hidayatullah, Jakarta.
Swarayana, I.M.I., I Wayan, S., dan I Ketut, B., Perubahan histopatologi hati mencit (Mus musculus) yang diberikan ekstrak daun ashitaba (Angelica keiskei), Buletin Veteriner Udayana. 2012; 4 (2).
Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta Tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik. 2014; 2 (2).
Dimas, A. P., Rahmah, F. S dan Setyaningrum, T. R., Potensi antihiperlipidemia ekstrak etanol daun bayam merah (Amaranthus tricolor L.) terstandar secara in vivo berdasarkan parameter LDL (Low Density Lipoprotein), Jurnal Sains Farmasi & Klinis. 2016; 2(2).
Kamesh, V., and Thangarajan, S., Antihypercholesterolemic effect of bacopa monniera linn on high cholesterol diet induced hypercholesterolemia in rats, Asian Pasific Journal Of Tropical Medicine. 2012
Umarudin, S., dan Yuniastuti, A., Efektivitas ekstrak tanin seledri terhadap profil hiperkolesterolemi lipid tikus putih, Jurusan Biologi FMIPA Universitas Negeri Semarang Indonesia, Unnes Journal of Life Science. 2012
Desi Sartina. Pengaruh ektraksi etanol lansau terhadap histopatologi organ hati tikus putih wistar jantan yang mengalami hiperlipidemia. Skripsi UHO; 2018
Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik; 2014 2 (2).
Rachmawati Syukur, Gemini Alam, Mufidah, Abdul Rahim, R. T., Aktivitas antiradikal bebas bebas beberapa ekstrak tanaman familia fabacea. Journal of Chemical Information and Modeling, 2013; 53(9), 1689-1699
Gilman, Goodman and Gilman: Dasar farmakologi terapi. Jakarta: EGC, 2012; Edisi 10. Vol 2,.
Ruslin, Henny K, Sunandar I, Suryani, Nur Samsiar, Ardiyanti, Zulfikar T, Rahmat D, Elsa, The identification of pharmacognostic on the extraction of tradisional medicine to lansau of Muna ethnic of Southeast Sulawesi Province. IAJPS 2017; 4 (11), 4170-4177
Elfrida, E., , Efek Antihiperlipidemia ekstrak etanol 70% buah parijoto (Medinilla speciosa Blume) terhadap jaringan hati tikus putih jantan, 2015; UIN Syarif Hidayatullah, Jakarta.
Swarayana, I.M.I., I Wayan, S., dan I Ketut, B., Perubahan histopatologi hati mencit (Mus musculus) yang diberikan ekstrak daun ashitaba (Angelica keiskei), Buletin Veteriner Udayana. 2012; 4 (2).
Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta Tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik. 2014; 2 (2).
Dimas, A. P., Rahmah, F. S dan Setyaningrum, T. R., Potensi antihiperlipidemia ekstrak etanol daun bayam merah (Amaranthus tricolor L.) terstandar secara in vivo berdasarkan parameter LDL (Low Density Lipoprotein), Jurnal Sains Farmasi & Klinis. 2016; 2(2).
Kamesh, V., and Thangarajan, S., Antihypercholesterolemic effect of bacopa monniera linn on high cholesterol diet induced hypercholesterolemia in rats, Asian Pasific Journal Of Tropical Medicine. 2012
Umarudin, S., dan Yuniastuti, A., Efektivitas ekstrak tanin seledri terhadap profil hiperkolesterolemi lipid tikus putih, Jurusan Biologi FMIPA Universitas Negeri Semarang Indonesia, Unnes Journal of Life Science. 2012
Desi Sartina. Pengaruh ektraksi etanol lansau terhadap histopatologi organ hati tikus putih wistar jantan yang mengalami hiperlipidemia. Skripsi UHO; 2018
Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik; 2014 2 (2).
Rachmawati Syukur, Gemini Alam, Mufidah, Abdul Rahim, R. T., Aktivitas antiradikal bebas bebas beberapa ekstrak tanaman familia fabacea. Journal of Chemical Information and Modeling, 2013; 53(9), 1689-1699
Gilman, Goodman and Gilman: Dasar farmakologi terapi. Jakarta: EGC, 2012; Edisi 10. Vol 2,.
Ruslin, Henny K, Sunandar I, Suryani, Nur Samsiar, Ardiyanti, Zulfikar T, Rahmat D, Elsa, The identification of pharmacognostic on the extraction of tradisional medicine to lansau of Muna ethnic of Southeast Sulawesi Province. IAJPS 2017; 4 (11), 4170-4177
Elfrida, E., , Efek Antihiperlipidemia ekstrak etanol 70% buah parijoto (Medinilla speciosa Blume) terhadap jaringan hati tikus putih jantan, 2015; UIN Syarif Hidayatullah, Jakarta.
Swarayana, I.M.I., I Wayan, S., dan I Ketut, B., Perubahan histopatologi hati mencit (Mus musculus) yang diberikan ekstrak daun ashitaba (Angelica keiskei), Buletin Veteriner Udayana. 2012; 4 (2).
Maramis, R., Marie, K., Tanudjadja, G.N., Gambaran histologi aorta Tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (Annona muricata L.), Jurnal E-Biomedik. 2014; 2 (2).
Dimas, A. P., Rahmah, F. S dan Setyaningrum, T. R., Potensi antihiperlipidemia ekstrak etanol daun bayam merah (Amaranthus tricolor L.) terstandar secara in vivo berdasarkan parameter LDL (Low Density Lipoprotein), Jurnal Sains Farmasi & Klinis. 2016; 2(2).
Kamesh, V., and Thangarajan, S., Antihypercholesterolemic effect of bacopa monniera linn on high cholesterol diet induced hypercholesterolemia in rats, Asian Pasific Journal Of Tropical Medicine. 2012
Umarudin, S., dan Yuniastuti, A., Efektivitas ekstrak tanin seledri terhadap profil hiperkolesterolemi lipid tikus putih, Jurusan Biologi FMIPA Universitas Negeri Semarang Indonesia, Unnes Journal of Life Science. 2012
Desi Sartina. Pengaruh ektraksi etanol lansau terhadap histopatologi organ hati tikus putih wistar jantan yang mengalami hiperlipidemia. Skripsi UHO; 2018
DOI: https://doi.org/10.24198/ijpst.v6i3.21611
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