Formulation and Physical Evaluation of Edible Film Dosage from Ethanol Extract of Betel Leaves (Piper betle L) for Canker Sore Drugs

Yenni Puspita Tanjung; Andi Ika Julianti; Aghnia Wulan Rizkiyani

doi:10.24198/ijpst.v8i1.29225

Formulation and Physical Evaluation of Edible Film Dosage from Ethanol Extract of Betel Leaves (Piper betle L) for Canker Sore Drugs

Yenni Puspita Tanjung, Andi Ika Julianti, Aghnia Wulan Rizkiyani

Abstrak

Canker sore which in medical terms is called aphthous stomatitis is a wound in the mouth that can cause pain and discomfort. Piper betel leaf can be used for strengthening the teeth, cure canker sores, treat the bad breath and stop the gum from bleeding. The research aimed to determine the edible film formula of betel leaf ethanol extract that met the physical evaluation requirements and to determine the effect of variation concentration of sorbitol and HPMC (Hydroxypropyl methylcellulose) on the physical evaluation. Edible film preparation from betel leaf extract is a thin layer made from the basic ingredients of corn starch, sorbitol, and HPMC. In this research, 3 edible film formulas were made with variations in the concentration of sorbitol and HPMC, namely: F1 (5%;5%), F2 (4%;4%), F3 (3%;3%). Data of evaluation results were analyzed statistics by Kruskal wallis method. The results showed that F1, F2 and F3 meet the physical evaluation requirements for edible film dosage. Variations in the concentration of sorbitol and HPMC gave different results significantly influence (p<0.05) on weight uniformity, film thickness, solubility and dissolution time, and did not significantly influence (p>0.05) on the organoleptic test, fragility of edible film, water resistance (swelling) and moisture content.

Keywords: Betel leaf extract, edible film, HPMC, canker sore, sorbitol

Teks Lengkap:

PDF

Referensi

Amtha R, Marcia M, Aninda AI. Plester sariawan efektif dalam mempercepat penyembuhan stomatitis aftosa rekuren dan ulkus traumatikus. Maj Kedokt Gigi Indonesa. 2017;3(2):69.

World Health Organization (WHO). WHO Traditional Medicine Strategy 2014-2023. World Heal Organ [Internet]. 2013;1–76. Available from: http://apps. who.int/iris/bitstream/10665/92455/1/97 8924150609O_eng.pdf?Ua=1

Sari DI, Fitriana Mi, Mulyadi RR, Hidayati L. Karakteristik dan uji stabilitas fisik sediaan edible film ekstrak etanol kulit batang kasturi (Mangifera casturi kosterm) berbasis gelatin. Pros Semin Kefarmasian dan Present Ilm. 2017;8–17

Sundari D, Almasyhuri A. Uji Aktivitas Antiseptik Ekstrak Etanol Daun Sirih (Piper betle Linn.) Dalam Obat Kumur terhadap Staphylococcus aureus secara in Vitro. J Kefarmasian Indones. 2019;9(1):10–8

Harmely F, Deviarny C, Yenni WS. Formulasi dan Evaluasi Sediaan Edible Film dari Ekstrak Daun Kemangi (Ocimum americanum L.) Sebagai Penyegar Mulut. J Sains Farm Klin. 2015;1(1):38.

Dewi, Mulya Arsita dan Dadang Mulya. Formulasi Dan Evaluasi Sifat Fisik Serta Uji Stabilitas Sediaan Edible Film Ekstrak Etanol 96 % Seledri (Apium graveolens L) Sebagai Penyegar Mulut Formulation and Evaluation of Physical Properties and Stability Test of Edible Film Oral dissolving film . 2019;4(2):32–40.

Santoso B, Pitayati PA, Pambayun R. Pemanfaatan Karaginan dan Gum Arabic Sebagai Edible Film Berbasis Hidrokoloid. 2013;33(2):140–5.

Rahmawati P, Ni’Maturrohmah D, Sari PL, Sari PP, Sari TNI, Suryanti V. Preparation and properties of arenga

starch-chitosan based edible film. IOP Conf Ser Mater Sci Eng. 2016;107(1).

Nofiandi D, Rahayu N, Putri N. Formulasi dan karakterisasi edible film dari poliblend pati umbi talas kimpul-polivinil alkohol dengan. 2019;9(2):183–91.

Murni W, Pawignyo H, Widyawati D, Sari N. Prosiding Seminar Nasional Teknik Kimia “Kejuangan” Pembuatan Edible Film dari Tepung Jagung (Zea Mays L.) Dan Kitosan. 2013;1–9.

Santoso B, Priyanto G. Karakteristik Edible Film dengan Penambahan Filtrat Gambir (Uncaria gambir Roxb ) dan Filtrat Daun Pepaya ( Carica papaya L.) Characteristics of Edible Film with Addition of the Gambir Filtrate ( Uncaria gambir Roxb ) and Papaya Leaf Filtrate ( Carica p. 2019;978–9.

Patil P, Shrivastava SK. Fast Dissolving Oral Films : a Novel Drug Delivery System. Int J Sci Res. 2014;3(7):2088–93.

Rusli A, Metusalach M, Tahir MM. Characterization of Carrageenan Edible films Plasticized with Glycerol. J Pengolah Has Perikan Indones. 2017;20(2):219.

Ballesteros-Mártinez L, Pérez-Cervera C, Andrade-Pizarro R. Effect of glycerol and sorbitol concentrations on mechanical, optical, and barrier properties of sweet potato starch film. NFS J [Internet]. 2020;20(June):1 9. Available from: https://doi.org/10.1016/j.nfs.2020.06.002

Sitompul AJWS, Zubaidah E. Pengaruh jenis dan konsentrasi plasticizer terhadap sifat fisik edible film kolang kaling (Arenga pinnata). J Pangan dan Agroindustri. 2017;5(1):13–25

DOI: https://doi.org/10.24198/ijpst.v8i1.29225