Isolation and Characterization Chemical Compounds From N-Hexane Extract of Zodia Leaves (Evodia suaveolens Scheff.)

Mutakin Mutakin; Wina Yunita; Titi Wirahardja Nikodemus

doi:10.24198/ijpst.v8i2.32401

Isolation and Characterization Chemical Compounds From N-Hexane Extract of Zodia Leaves (Evodia suaveolens Scheff.)

Mutakin Mutakin, Wina Yunita, Titi Wirahardja Nikodemus

Abstrak

Zodia (Evodia suaveolens Scheff.) (Rutaceae) is one of Indonesia's native plants, which comes from Papua which is widely used as traditional medicine. Empirically, zodia leaves are used as anti-mosquitoes, dysentery drugs, boiled bark is useful as a reliever for malaria fever, leaf decoction is used as a tonic, and increases stamina. Until now, no investigation has been carried out for the main compounds of the zodia leaf n-hexane extract which have proven activity. Therefore, it was done the isolation and characterization of the main compound in the zodia leaf n-hexane extract (Evodia suaveolens Scheff.). Zodia leaves were extracted with n-hexane using the Soxhlet tool. The n-hexane extract was fractionated using column chromatography with a gradient of n-hexane-chloroform mixture. Isolates were isolated in the form of white needle crystals which were purified by washing with n-hexane. Isolates were characterized by analyzing various UV, IM, 1D and 2D RMI spectrometry data which were confirmed by analyzing the mass spectrum. Based on the results of spectrometric analysis, it is known that the isolate is thought to be a triterpenoid compound, namely neohop-13 (18) -ene-3α-ol.

Keywords: Evodia suaveolens, neohop-13(18)-ene-3α-ol, triterpenoide,

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Referensi

Guastaldi R, Reis A, Figueras A, Secoli S. Prevalence of potential drug-drug interactions in bone marrow transplant patients. Int J Clin Pharm. 2011;33(6):1002-9.

L. Susanti, H. Boesri. Toksisitas Biolarvasida Ekstrak Tembakau dibandingkan dengan Ekstrak Zodia terhadap Jentik Vektor Demam Berdarah Dengeu (Aedes Aegypti). Bul. Pen. Kes. 2012;40:75-84,

Evi Mintowati Kuntorini E.M, Nofaliana D., and Pujawati E.D, Anatomical Structure and Terpenoid Content of Zodia (Evodia suaveolens Scheff) Leaves, BIO Web of Conferences, 2020; 20:03001

Mirawati P, Simareme E.V, Pratiwi R.D. Uji Efektivitas Repellent Sediaan Lotion Kombinasi Minyak Atsiri Daun Zodia (Evodia suaveolens Scheff) dan minyak atsiri batang serai (Cymbopogon citratrus) terhadap Nyamuk Aedes aegypti L, Pharmacy: Jurnal Farmasi Indonesia,2018; 15(1):1-15

Lestari, F.D dan Simareme E,S, Uji Potensi Minyak Atsiri daun Zodia (Evodia suaveolens Scheff) sebagai insektisida nyamuk Aedes Aegypti dengan metode elektrik, Pharmacy, 2017;14(1): 1-10

Simareme E.S., Manurung, L., Gunawan E, dan Maryuni, A.E, Zodia (Evodia suaveolens Scheff) in liquid soap as repellent against Aedes aegypti K. Advances Scienes Letters, 2018; 24:91-94

Kardinan, A. 2004. Zodia (Evodia suaveolens) : Tanaman Pengusir Nyamuk. www.litbang.deptan.go.id, diakses 11 Februari 2020

Farnsworth, N.R. Biological and Phytochemical Screening of Plant. J. Pharm. Sci. 1966; 55(3): 243-269

Branco, Alexandro, A. Pinto, Ramundo B. F. Chemical Constituens from Vellozia graminifolia (Velloziaceae). An. Acad. Braz. Cienc. 2004;76(3): 505-518

Akihisa, Toshihiro & L. John Goad. Analysis of Sterols. Blackie Academic & Professional. Tokyo. Japan. 1997; 2:23-39

Sanora, G., Mastura, E. Y., Handoyo, M. O. M., & Purnama, E. R. Identification of Anticancer Active Compound from GC-MS Test Results of Zodia Leaves (Evodia suaveolens) Ethanol Extract. Jurnal Biota, 2019;5(2):89-95.

Hadi M., , Setiyadi D., Mawarni A., Martini M. , Sutiningsih D.,Suwondo A., Potential of Zodia Leaf Extracts of Hexane Solvent in Reducing Aedes aegypti Density: Semi-Field Trial Application in Endemic Areas of Dengue Hemorrhagic Fever (DHF), Annals of Tropical Medicine & Public Health, 2021;24(1):1-7

Ngibad K., Lestari L.P.,. ISSN : 2085-4714 161 Uji Fitokimia Dan Aktivitas Antioksidan Ekstrak Metanol Daun Zodia (Evodia suaveolens), As-Syifaa Jurnal Farmasi, 2019; 11 (2):161-168

DOI: https://doi.org/10.24198/ijpst.v8i2.32401