Formulation and Characterization Liposome of Oxcarbazepine

Dina Permata Wijaya; Budi Untari; Herlina Herlina; Putri Siti Rahayu

doi:10.24198/ijpst.v10i2.33707

Formulation and Characterization Liposome of Oxcarbazepine

Dina Permata Wijaya, Budi Untari, Herlina Herlina, Putri Siti Rahayu

Abstrak

Oxcarbazepine (OXC) was used as first line therapy or additional therapy for treatment of partial
and secondary of seizures. The penetration of OXC into nasal mucosa can be enhanced by forming
liposome. This research has the aim to prepare and characterize iposome laoding OXC. The OXC
liposome formula was composed by using soya lechitin and cholesterol with various amount using
thin film hydration method. Characterization by determining the encapsulation efficiency (%EE), pH,
viscosity, particle size, polydispersity of index, zeta potential, and in vitro release. The liposome of
OXC was also analyzed for its stability based on heating-coling cycle method. The proportion of best
formula was obtained at the amount of cholesterol of 42,11 mg yield %EE of 92,63%, pH of 8,47,
viscosity of 1,10 cP, and decreased amount of OXC in stability test of 0,34%. The results of particle
diameter were 579 nm, polydispersity index (PDI) of 0,34, and zeta potential of -99,38 mV. The in vitro
release of the liposome of OXC was studied and compared with OXC. The result of in vitro release
liposome OXC (F2) ahowed increase (62,26%) than (41,97%).

Kata Kunci

liposome, oxcarbazepine, cholesterol, PDI, encapsulation.

Teks Lengkap:

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DOI: https://doi.org/10.24198/ijpst.v10i2.33707

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