Indonesian Journal of Pharmaceutical Science and Technology
Solvent Type Effect on Preparation of Ethyl Cellulose Microparticles
Abstrak
The purpose of this study was to investigate effect of solvent type on solidification rate of ethyl
cellulose (EC) microparticles and particle size/distribution of emulsion droplets/hard microparticles
during the solvent evaporation process using focused beam reflectance measurement (FBRM). EC
microparticles were prepared by an O/W-solvent evaporation method using various solvents, including
dichloromethane, dichloromethane:methanol (1:1), ethyl acetate, and chloroform. The particle size/
distribution of emulsion droplets/hard microparticles was monitored by FBRM. The morphology of
EC microparticles was characterized by scanning electron microscopy (SEM). The transformation of
emulsion droplets into solid microparticles for all solvents occured within the first 10-60 min. The
square weighted mean chord length of EC microparticles which were prepared using chloroform was
smallest value, but the chord counts was no the highest. The chord length distribution (CLD) measured
by FBRM showed that microparticles with a larger diameter give a wider CLD and a lower peak
number of particles. SEM data shows that the morphology of microparticles was influenced by type of
solvent. FBRM can be used to monitor the development of microparticle CLDs online and detect the
transformation of emulsion droplets into solid microparticles during the solvent evaporation process.
The microparticle CLD and transformation processes are influenced by the type of solvent.
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Bodmeier, R., McGinity, J. W. Solvent
selection in the preparation of poly(D,L-
lactide) microspheres prepared by the
solvent evaporation method. Int. J. Pharm.
, 179-186 (1988).
Boxall, J. A., Koh, C. A., Sloan, E. D.,
Sum, A. K., Wu, D. T. Measurement and
calibration of droplet size distributions
in water-in-oil emulsions by particle
video microscope and a focused beam
reflectance method. Ind. Eng. Chem. Res.
, 1412-1418 (2010).
Cleland, J. L., Lim, A., Barrón, L.,
Duenas, E. T., Powell, M. F. Development
of a single-shot subunit vaccine for HIV-
: Part 4. Optimizing microencapsulation
and pulsatile release of MN rgp120 from
biodegradable microspheres. J. Control.
Rel. 47,135-150 (1997).
Freitas, S., Merkle, H. P., Gander, B.
Microencapsulation by solvent extraction/
evaporation: reviewing the state of the
art of microsphere preparation process
technology. J. Control. Rel. 102, 313–332
(2005).
Simao, A. R., Fragal, V. H. & Rubira, A.
F. Drug polarity effect over the controlled
release in casein and chondroitin sulfate-
based hydrogels. Int. J. Biol. Macromol.
, 116-126 (2020).
Song, W., Zhao, G., Zheng, H., He, G.,
Li, J., Zhang, J., Chen, Y. & Wang, Y.
Chitosan capsules with hydrogel core for
encapsulation and controlled-release of
small molecule materials. Materi. Let.
, 128348 (2020).
Sui, C., Preece, J. A., Zhang, Z. & Yu,
S. H. Efficient encapsulation of water
soluble inorganic and organic actives
in melamine formaldehyde based
microcapsules for control release into an
aqueous environment. Chem. Eng. Sci.
116103 (2021).
Tang, L., Chen, Y. H., Wang, Q.,
Wang, X. H., Wu, Q. X. & Ding, Z.
F. Microencapsulation of functional
ovalbumin and bovine serum albumin
with polylysine-alginate complex for
sustained protein vehicle’s development.
Food Chem. 368, 130902 (2022).
Yang, Z., Zhang, X., Li, Y., Yang, Y.,
Chen, N., Wang, X. & Xie, Q. Fabrication
of KDF-loaded chitosan-oligosaccharide-
encapsulated konjac glucomannan/
sodium alginate/zeolite P microspheres
with sustained-release antimicrobial
activity. J. Mol. Struct. 1250, 131682
(2022).
Bhageri, A. R., Golenser, J. & Greiner,
A. Controlled and manageable release of
antimalarial Artemisone by encapsulation
in biodegradable carriers. Eur. Polym. J.
, 109625 (2020).
Chen, M., Yan, X., Cheng, M., Zhao, P.,
Wang, Y., Zhang, R., Wang, X., Wang, J.
& Chen, M. Preparation, characterization
and application of poly(lactic acid)/
corn starch/eucalyptus leaf essential
oil microencapsulated active bilayer
degradable film. Int. J. Biol. Macromol.
, 264-273 (2022).
Chroni, A. & Pispas, S. Hydrophilic/
hydrophobic modifications of a PnBA-b-
PDMAEA copolymer and complexation
behaviour with short DNA. Eur. Polym.
J. 129, 109636 (2020).
Eskandari, P., Rezvani, Z. A., Hajebi,
S., Mamaqani, H. R. & Kalajahi, M. S.
Controlled release of anti-cancer drug
from the shell and hollow cavities of
poly(N-isopropylacrylamide) hydrogel
particles synthesized via reversible
addition-fragmentation chain transfer
polymerization. Eur. Polym. J. 135,
(2020).
Guo, T., Wangxia, W., Song, J., Jin, Y. &
Xiao, H. Dual-responsive carboxymethyl
cellulose/dopamine/cystamine hydrogels
driven by dynamic metal-ligand and
redox linkages for controllable release
of agrochemical. Carbohyd. Polym. 253,
(2021).
Lin, D., Xiao, L., Li, S., Qin, W., Loy,
D. A., Chen, H. & Zhang, Q. Effects
of fructooligosaccharide and soybean
protein isolate in the microencapsulation
of walnut oil. Industr. Crop. Prod. 177,
(2022).
Mady, O. Application of solvent
evaporation technique for pure drug
crystal spheres preparation. Particuol. 67,
-89 (2022).
Mandaji, C. M., Pena, R. S. & Chiste, R.
C. Encapsulation of bioactive compounds
extracted from plants of genus Hibiscus:
A review of selected techniques and
applications. Food Res. Int. 151, 110820
(2022).
Mo, B., Mo, S., Jia, L., Wang, Z. & Chen,
Y. Microencapsulation of ethanol-soluble
inorganic salts for high temperature
thermal energy storage. Materi. Chem.
Phys. 275, 125261 (2022).
Muhaimin, M., Yusnaidar, Y., Syahri,
W., Latief, M. & Chaerunisaa, A. Y.
Microencapsulation of Macaranga
gigantea Leaf Extracts: Production and
Characterization. Pharmacog. J. 12 (4),
-724 (2020).
Ong, P. J., Png, Z. M., Soo, X. Y. D.,
Wang, X., Suwardy, A. Chua, M. H., Xu,
J. W. & Zhu, Q. Surface modification of
microencapsulated phase change materials
with nanostructures for enhancement of
their thermal conductivity. Materi. Chem.
Phys. 277, 125438 (2022).
Ricci, A., Mejia, J. A. A., Versari, A.,
Chiarello, E., Bordoni, A. & Parpinello,
G. P. Microencapsulation of polyphenolic
compounds recovered from red wine lees:
Process optimization and nutraceutical
study. Food Bioprod. Proces. 132, 1-12
(2022).
Muhaimin, M., Chaerunisaa, A. Y.
& Bodmeier, R. Real-time particle
size analysis using focused beam
reflectance measurement as a process
analytical technology tool for continuous
microencapsulation process. Sci. Rep. 11,
(2021).
Sankaranarayanan, S., Likozar, B. &
Navia, R. Real-time particle size analysis
using the focused beam reflectance
measurement probe for in situ fabrication
of polyacrylamide–filler composite
materials. Sci. Rep. 9, 1–12 (2019).
Sarwar, M. S., Ghaffar, A., Huang,
Q., Zafar, M. S., Usman, M. & Latif,
M. Controlled-release behavior of
ciprofloxacin from a biocompatible
polymeric system based on sodium
alginate/poly(ethylene glycol) mono
methyl ether. Int. J. Biol. Macromol. 165,
-1054 (2020).
Graves, R. A., Freeman, T., Pamajula,
S., Praetorius, N., Moiseyev, R.,
Manda,l T. K. Effects of co-solvents
on the characteristics of enkephalin
microcapsules. J. Biomater. Sci. Polym.
Edit. 17, 709-720 (2006).
Jeyanthi, R., Metha, R. C., Thanoo, B.
C., Deluca, P. P. Effect of processing
parameters on the properties of peptide
containing PLGA microspheres. J.
Microencapsul. 14, 163-174 (1997).
Wu, H., White, M. & Khan, M. A.
Quality-by-Design (QbD): An integrated
process analytical technology (PAT)
approach for a dynamic pharmaceutical
co-precipitation process characterization
and process design space development.
Int. J. Pharm. 405, 63-78 (2011).
Zhang, H., Chen, K. & Yang,
J. Development of a versatile
microencapsulation technique for
aqueous phases using inverse emulsion.
Coll. Surf. A: Physicochem. Eng. Asp.
, 127865 (2022).
Kirwan, L. J. Investigating bauxite
residue flocculation by hydroxamate
and polyacrylate flocculants utilising the
focussed beam reflectance measurement
probe. Int. J. Miner. Process. 90, 74-80
(2009).
Kougoulos, E., Jones, A. G., Kaczmar,
M. W. Modelling particle disruption
of an organic fine chemical compound
using Lasentec focussed beam reflectance
monitoring (FBRM) in agitated
suspensions. Powder Technol. 155,153-
(2005).
Leba, H., Cameirao, A., Herri, J. M.,
Darbouret, M., Peytavy, J. L. Chord
length distributions measurements during
crystallization and agglomeration of
gas hydrate in a water-in-oil emulsion:
Simulation and experimentation. Chem.
Eng. Sci. 65, 1185-1200 (2010).
Li, M., Rouaud, O., Poncelet, D.
Microencapsulation by solvent
evaporation: State of the art for process
engineering approaches. Int. J. Pharm.
, 26-39 (2008).
Vay, K., Frieβ, W., Scheler, S.
Understanding reflection behavior as
a key for interpreting complex signals
in FBRM monitoring of microparticle
preparation processes. Int. J. Pharm. 437,
-10 (2012).
Zidan, A. S., Rahman, Z., Khan,
M. A. Online monitoring of PLGA
microparticles formation using Lasentec
focused beam reflectance (FBRM) and
particle video microscope (PVM). AAPS
J. 12, 254-262 (2010).
Silva, A. F. T., Burggraeve, A., Denon,
Q., Van der Meeren, P., Sandler, N., Van
Den Kerkhof, T., Hellings, M., Vervaet,
C., Remon, J. P., Lopes, J. A. & De
Beer, T. Particle sizing measurements in
pharmaceutical applications: Comparison
of in-process methods versus off-line
methods. Eur. J. Pharm. Biopharm.
(2013).
Vajihinejad, V. & Soares, J. B. P.
Monitoring polymer flocculation in oil
sands tailings: A population balance
model approach. Chem. Eng J. 346, 447-
(2018).
Kail, N., Briesen, H. & Marquardt, W.
Analysis of FBRM measurements by
means of a 3D optical model. Powder
Technol. 185, 211-222 (2008).
Kail, N., Marquardt, W. & Briesen, H.
Estimation of particle size distributions
from focused beam reflectance
measurements based on an optical model.
Chem. Eng. Sci. 64, 984-1000 (2009).
Murtaza, G. Ethylcellulose microparticles:
A review. Drug Res. 69, 11-22 (2012).
DOI: https://doi.org/10.24198/ijpst.v10i3.38460
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