Cardioprotective activity of Apples Juice on Isoproterenol-Induced  Myocardial Infarction in Rat

Neng Fisheri Kurniati; Yuthika Raihan Nadhirah

doi:10.24198/ijpst.v10i3.41445

Cardioprotective activity of Apples Juice on Isoproterenol-Induced Myocardial Infarction in Rat

Neng Fisheri Kurniati, Yuthika Raihan Nadhirah

Abstrak

Myocardial infarction was local necrosis of heart tissue due to reduced oxygen supply because of the
occlusion of coronary arteries. Fruits could reduce the risk of developing obesity and CVDs. Several
studies have shown that apples had a strong cardioprotective effect. This study aimed to understand
the cardioprotective activity of two variants of apples, e.g., Fuji and Malang, on isoproterenol-induced
male Wistar rats. The cardioprotective activity test was carried out for 14 days, all testing group except
negative control, was induced by isoproterenol. The results of testing cardioprotective activity showed
that Fuji Apple juice and Apel Malang juice had the same capability to inhibit increasing cardiac
biomarkers value (CK and CK-MB) with the highest inhibition was 79.56% and 73.08% for Fuji
Apples, respectively, while for Apel Malang was 69.18% and 43.04%, respectively. The result of the
cardiac histopathology examination showed that both Apples could prevent cardiac tissue damage. All
juice Apple doses had the same cardioprotective activity.

Kata Kunci

cardioprotective, myocardial infarction, isoproterenol, Fuji Apple, Apel Malang.

Teks Lengkap:

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DOI: https://doi.org/10.24198/ijpst.v10i3.41445

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