Formulation And Characterization Of Buccal Film Nanoemulsion Apigenin As Antidiabetic

Ardianes Firmansya; Fajar Setiawan; Lusi Nurdianti; Anna Yuliana

doi:10.24198/ijpst.v1i1.42829

Formulation And Characterization Of Buccal Film Nanoemulsion Apigenin As Antidiabetic

Ardianes Firmansya, Fajar Setiawan, Lusi Nurdianti, Anna Yuliana

Abstrak

Apigenin (4`,5,7-trihydroxyflavone) is a flavonoid of subclass flavones that have antidiabetic
therapeutic activity but limitations BCS Class II low solubility of 2.16 μg/L. To overcome these
limitations, the development of nanoemulsion formulation technology, increasing solubility increases
dissolution, absorption and bioavailability. It is incorporated into the buccal film for easy application
and direct access to the systemic circulation. This study aims to obtain apigenin nanoemulsion with
the best characterization and buccal film that meets the characterization. The method was carried out
experimentally in the manufacture of nanoemulsions by spontaneous emulsification, a buccal film
by solvent casting, and the characterization. 10 nanoemulsion formulas met the characterization
with globule size <20.34nm, polydispersity index <0.131, zeta potential close to 0mV, pH 6.23-
6.59, %transmittance close to 100% and best F10 incorporated into buccal film has 29x the solubility
compared to apigenin with p≤0.05. All buccal films met the characterization with F3 having a 2x faster
onset of release than F1&F2 with 86.07% diffusion and 97.9333 mg/sheet. Thus, it was concluded
that the formulation and characterization of buccal film fulfilled the characterization and F10 apigenin
nanoemulsion increased the solubility 29-fold with the buccal film F3 having a faster onset of release.

Kata Kunci

Apigenin; BCS; Solubility; Nanoemulsion; Buccal Film

Teks Lengkap:

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DOI: https://doi.org/10.24198/ijpst.v1i1.42829