Antihyperuricemia Activity Of Kupa (Syzygium polycephalum) Seed Extracts In Male White Mice

Ira Rahmiyani; Trian Nur'aripin; Anisa Pebiansyah; Resha R. Shaleha

doi:10.24198/ijpst.v1i1.42882

Antihyperuricemia Activity Of Kupa (Syzygium polycephalum) Seed Extracts In Male White Mice

Ira Rahmiyani, Trian Nur'aripin, Anisa Pebiansyah, Resha R. Shaleha

Abstrak

Hyperuricemia is a clinical condition of increasing uric acid in the blood beyond normal. Increased
levels of uric acid can accumulate monosodium urate crystals. Kupa fruit seeds contain flavonoids,
saponins, tannins, and polyphenols which have antihyperuricemia activity. This study aims to
determine the best antihyperuricemia activity of several kupa seed extracts. The study was conducted
in vivo using male white mice. Negative, positive, n-hexane extract, ethanol extract, and ethyl acetate
extract were induced by acetylsalicylic acid 5.04 mg/20gBW of mice and fructose 67.2 mg/20gBW
of mice orally for 3 days. On the 3rd day of treatment, the positive group was given allopurinol 0.997
mg/20gBW and the 3 test groups were each given a different extract of 1.82 mg/20gBW mice orally
for 7 days. The results showed the ethanol extract of Kupa fruit seeds had the best antihyperuricemia
activity with a decrease in uric acid levels of 68.29%. Based on the results, the group of mice treated
with ethanol extract had significantly different activity from the negative control group p <α (0.015
<0.05). The ethanol extract showed the best antihyperuricemia activity approaching allopurinol as a
positive control.

Kata Kunci

Hyperuricemia, Syzygium polycephalum, seed.

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/ijpst.v1i1.42882