Formulation and Characterization Sunscreen Emulgel Containing Cinnamon Bark Oil (Cinnamomum Burmannii Nees Ex Blume)

Sani Ega Priani

Abstrak


Cinnamon bark oil is known to contain high levels of cinnamaldehyde (>50%). Cinnamaldehyde is an aromatic compound that is conjugated with a carbonyl group and potential to have photoprotective activity. The purpose of this study was to develop an emulgel preparation containing cinnamon bark oil and to evaluate the  emulgel in terms of its physical properties, stability, and sunscreen activity. Cinnamon bark oil was characterized based on SNI 06-3734-2006. Cinnamon bark oil at concentrations of 0.5 and 1 % was formulated into an emulgel using a combination of stearic acid and triethanolamine as an emulsifier and viscolam mac 10 as a gelling agent. The preparation was evaluated for its physical characteristics and stability. The sunscreen activity test was carried out in vitro by determining the Sun Protection Factor's values (SPF), % erythema, and % pigmentation.  The results showed that cinnamon oil met the SNI standards of cinnamaldehyde concentration (53.33 %). Cinnamon oil emulgel preparation has good physical properties in terms of organoleptic, pH, viscosity, rheology, spreadability, and stability based on centrifugation and freeze-thaw tests. The addition of 0.5 and 1% of cinnamon oil significantly increased the sunscreen activity of the emulgel based on the SPF, % erythema, and % pigmentation values with the extra protection category. An emulgel containing cinnamon bark oil has been successfully developed which has good physical properties and stability and has sunscreen activity based on the value of FPS, % erythema, and % pigmentation.

 


Kata Kunci


Cinnamon bark oil, cinnamaldehyde, sunscreen, emulgel

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Referensi


. Alfredsson L, Armstrong BK, Allan Butterfield D, Chowdhury R, de Gruijl FR, Feelisch M, et al. Insufficient sun exposure has become a real public health problem. Vol. 17, International Journal of Environmental Research and Public Health. 2020. https://doi.org/10.3390/ijerph17145014

. Amaro-Ortiz A, Yan B, D’Orazio JA. Ultraviolet radiation, aging and the skin: Prevention of damage by topical cAMP manipulation. Vol. 19, Molecules. 2014. https://doi.org/10.3390/molecules19056202

. D’Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. International Journal of Molecular Sciences. 2013. https://doi.org/10.3390/ijms140612222

. saes da Silva E, Tavares R, da silva Paulitsch F, Zhang L. Use of sunscreen and risk of melanoma and non-melanoma skin cancer: a systematic review and meta-analysis. Eur J Dermatology. 2018;28(2). https://doi.org/10.1684/ejd.2018.3251

. Ozga-Stachurska AM, Wójcik-Grudzień J, Pawłowska P, Rozenbajgier M. Do sunscreens have more positive or negative effects? Study review. J Educ Heal Sport. 2022;12(9). https://doi.org/10.12775/jehs.2022.12.09.081

. Geoffrey K, Mwangi AN, Maru SM. Sunscreen products: Rationale for use, formulation development and regulatory considerations. Saudi Pharmaceutical Journal. 2019. https://doi.org/10.1016/j.jsps.2019.08.003

. Robinson J. Science of sunscreen. Pharm J. 2017;298(7902). https://doi.org/10.1211/PJ.2017.20203013

. Priani SE, Humanisya H, Darusman F. Development of Sunscreen Emulgel Containing Cinnamomum Burmannii Stem Bark Extract. Int J Sci Res ISSN (Online Impact Factor. 2012;

. Subash-Babu P, Alshatwi AA, Ignacimuthu S. Beneficial antioxidative and antiperoxidative effect of cinnamaldehyde protect streptozotocin-induced pancreatic β-cells damage in wistar rats. Biomol Ther. 2014;22(1). https://doi.org/10.4062/biomolther.2013.100

. Kopong Tok M, Budiana IGMN, . N, Maria Imak M. Hedonic Test of Sunscreen Cream Formula Made of Cinnamaldehyde of Cinnamon from Timor Island. Trends Appl Sci Res. 2020;15(2). https://doi.org/10.3923/tasr.2020.81.86

. Leon-Méndez G, Osorio-Fortich M, Ortega-Toro R, Pajaro-Castro N, Torrenegra-Alarcón M, Herrera-Barros A. Design of an emulgel-type cosmetic with antioxidant activity using active essential oil microcapsules of thyme (Thymus vulgaris L.), Cinnamon (Cinnamomum verum J.), and clove (Eugenia caryophyllata T.). Int J Polym Sci. 2018;2018. https://doi.org/10.1155/2018/2874391

. Sreevidya VS. An Overview on Emulgel. International Journal of Pharmaceutical and Phytopharmacological Research. 2019.

. Saryanti D, Setiawan I, Safitri RA. Optimasi Asam Stearat Dan Tea Pada Formula Sediaan Krim Ekstrak Kulit Pisang Kepok (Musa paradisiaca L.). J Ris Kefarmasian Indones. 2019;1(3). https://doi.org/10.33759/jrki.v1i3.44

. Priani SE, Lestari IA, Lestari F. Pengembangan Sediaan Emulgel Mengandung Minyak Biji Anggur (Vitis Vinifera L.) Dan Uji Aktvitas Antiluka Terhadap Tikus Wistar Jantan (Rattus norvegicus). J Ilm Ibnu Sina Ilmu Farm dan Kesehat. 2019; https://doi.org/10.36387/jiis.v4i1.233

. Berdey II, Voyt OI. Rheological properties of emulgel formulations based on different gelling agent. Pharma Innov J TPI. 2016;

. Tambunan S, Sulaiman TNS. Formulasi Gel Minyak Atsiri Sereh dengan Basis HPMC dan Karbopol. Maj Farm. 2018;

. Sathya S, Herath HMDR, Amarasinghe NR, Suraweera RK. Formulation development of cream incorporating extracts of Glycyrrhiza glabra (Licorice). Pharm J Sri Lanka. 2017;7(0). https://doi.org/10.4038/pjsl.v7i0.19

. Noviardi H, Ratnasari D, Fermadianto M. Formulasi Sediaan Krim Tabir Surya dari Ekstrak Etanol Buah Bisbul (Diospyros blancoi). J Ilmu Kefarmasian Indones. 2019;17(2). https://doi.org/10.35814/jifi.v17i2.771

. Abdassah M, Aryani R, Surachman E, Muchtaridi M. In-vitro assessment of effectiveness and photostability avobenzone in cream formulations by combination ethyl ascorbic acid and alpha tocopherol acetate. J Appl Pharm Sci. 2015; https://doi.org/10.7324/JAPS.2015.50611

. Nguyễn Thương T. Research On Chemical Composition And Antioxidant Activity Of Cinnamomum Burmannii Essential Oil In Bao Lac, Cao Bang Province. Sci J Tan Trao Univ. 2022;8(3). https://doi.org/10.51453/2354-1431/2022/805

. Rao PV, Gan SH. Cinnamon: A multifaceted medicinal plant. Evidence-based Complementary and Alternative Medicine. 2014. https://doi.org/10.1155/2014/642942

. Rai R, Shanmuga S, Srinivas CR. Update on photoprotection. Indian J Dermatol. 2012; https://doi.org/10.4103/0019-5154.100472

. Widiyati E, Bambang Setiaji AH, Suharto TE, Triyono. The effect of stearic acid and triethanolamine (tea) on physical and chemical properties of cosmetic emulsion using coconut oil as raw material. Int J Appl Chem. 2015;11(3).

. Bhattacharya S, Sherje AP. Development of resveratrol and green tea sunscreen formulation for combined photoprotective and antioxidant properties. J Drug Deliv Sci Technol. 2020;60. https://doi.org/10.1016/j.jddst.2020.102000

. Priani SE, Azhari Abdilla S, Suparnan A. Pengembangan Sediaan Mikroemulsi Gel Antijerawat Mengandung Minyak Kulit Batang Kayu Manis (Cinnamomum burmanni Nees ex Bl). J Ilm Farm Farmasyifa. 2020;3(1). https://doi.org/10.29313/jiff.v3i1.5464

. Garg A, Aggarwal D, Garg S, Singla AK. Spreading of semisolid formulations: An update. Pharmaceutical Technology North America. 2002.

. Naga Sravan Kumar Varma V, Maheshwari P V., Navya M, Reddy SC, Shivakumar HG, Gowda D V. Calcipotriol delivery into the skin as emulgel for effective permeation. Saudi Pharm J. 2014;22(6). https://doi.org/10.1016/j.jsps.2014.02.007

. Chen MX, Alexander KS, Baki G. Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application. J Pharm. 2016;2016. https://doi.org/10.1155/2016/5754349

. Hamsinah H, Darijanto SD, Mauluddin R. Uji Stabilitas Formulasi Krim Tabir Surya Serbuk Rumput LauT (Eucheuma cottonii. Doty). J Fitofarmaka Indones. 2016; https://doi.org/10.33096/jffi.v3i2.215

. Suharsanti R, Sugihartini N, Lukitaningsih E, Radix Rahardhian MR. In vitro assessment of total phenolic, total flavonoid and sunscreen activities of crude ethanolic extract of belimbing wuluh (Averrhoa bilimbi) fruits and leaves. J Glob Pharma Technol. 2019;11(4).




DOI: https://doi.org/10.24198/ijpst.v12i1.46573

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