Urea Reduction Ratio for CKD Stage 5 Hemodialysis Patients at Dr Pirngadi Hospital Medan

Eva Sartika Dasopang; Fenny Hasanah; Salmah Handayani; Verawati L. Daya; Yelda R. Thaharah; Thalita Sandika

doi:10.24198/ijpst.v12i2.50702

Urea Reduction Ratio for CKD Stage 5 Hemodialysis Patients at Dr Pirngadi Hospital Medan

Eva Sartika Dasopang, Fenny Hasanah, Salmah Handayani, Verawati L. Daya, Yelda R. Thaharah, Thalita Sandika

Abstrak

Stage 5 CKD is a severe form of kidney disease with a GFR value of <15 mL/min/1.73 m2. Haemodialysis is a replacement therapy that removes metabolic waste, including urea. The text discusses a study conducted at Dr. Pirngadi Hospital in Medan City to compare pre- and post-urea values and URR (urea reduction ratio) in patients with stage 5 chronic kidney disease (CKD) undergoing haemodialysis. The study used retrospective data from CKD stage 5 patients with complete medical records and pre- and post-urea laboratory results. The results of the study revealed that the haemodialysis process was effective, with a significant difference in pre- and post-urea values (p<0.05). The average pre-urea value was 114.29 mg/dL, while the average post-haemodialysis urea value was 37.85 mg/dL. The URR was found to be 67.46%. However, it was concluded that adequate haemodialysis in stage 5 CKD patients at Dr. Pirngadi Hospital had not reached 100%.

Kata Kunci

adequacy; CKD stages 5; hemodialysis; pre-post urea; urea reduction ratio (URR)

Teks Lengkap:

PDF

Referensi

Irawan PA. Pemeriksaan fungsi ginjal. J Diabetes. 2020;43(2).

GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225).

Zuanda O. Karakteristik penderita gagal ginjal kronik yang menjalani hemodialisis di RSUD Dr. Pirngadi Medan tahun 2017 [skripsi]. Universitas Sumatera Utara; 2018.

Hasanah U, Hammad H, Rachmadi A. Hubungan kadar ureum dan kreatinin dengan tingkat fatigue pada pasien chronic kidney disease (CKD) yang menjalani hemodialisa. J Citra Keperawatan. 2020;8(2).

Suryawan, Arjani DS. Gambaran kadar ureum dan kreatinin serum pada pasien gagal ginjal kronis yang menjalani terapi hemodialisis. Compr Clin Nephrol. 2016;(1).

Fahmi K, Nina G, Angga W. Hubungan adekuasi hemodialisis urea reduction rate (URR) dengan tingkat fatigue pada pasien end stage renal disease (ESRD). Bandung; 2019.

Liang KV, Zhang JH, Palevsky PM. Urea reduction ratio may be a simpler approach for measurement of adequacy of intermittent hemodialysis in acute kidney injury. BMC Nephrol. 2019;20(1):1–7.

Manus SA, Moeis E, Mandang V. Perbandingan fungsi kognitif sebelum dan sesudah dialisis pada pasien penyakit ginjal kronik. E-Clinic. 2015;3(3).

Yusria L, Retno S. Diagnosis dan manajemen glomerulonefritis. J Kedokteran Muhammadiyah Surakarta. 2020.

Lees JS, Shlipak MG. Age-adapted eGFR thresholds underestimate risks beyond kidney failure associated with CKD in older populations. J Am Geriatr Soc. 2022;70(12):3660–4.

Riska WM, Arifin Noor M. Effect of the combination of ankle pump exercise and 30° foot elevation on foot edema in CKD patients. J Keperawatan Sisthana. 2023;8(1):2636.

Alayyannur PA, Ramdhan DH. Relationship of heat stress with acute kidney disease and chronic kidney disease: a literature review. J Public Health Res. 2022;11(2).

Di Polito N, Stylianakis AA, Richardson R, Baker KD. Real-world intake of dietary sugars is associated with reduced cortisol reactivity following an acute physiological stressor. Nutrients. 2023;15(1).

Dai L, Lu C, Liu J, Li S, Jin H, Chen F, …., Miao C. Impact of twice- or three-times-weekly maintenance hemodialysis on patient outcomes: a multicenter randomized trial. Medicine (Baltimore). 2020;99(20).

Lee WL, Cheng MH, Tarng DC, Yang WC, Lee FK, Wang PH. The benefits of estrogen or selective estrogen receptor modulator on kidney and CKD-mineral and bone disorder: osteoporosis. J Chin Med Assoc. 2013;76(7).

Suandewi DASA, Sugiarta IGRM, Astawa NT, Ekariawan IP. Profil penderita chronic kidney disease stadium 5 yang menjalani hemodialisis reguler di RSUD Klungkung. Intisari Sains Medis. 2020;11(2).

Saraswati NLGI, Lestari NKY, Putri KA. Hubungan tingkat stres dengan kualitas tidur pada pasien gagal ginjal kronik yang menjalani hemodialisis. Malahayati Nurs J. 2022;4(5).

Fatonah L, Andayani TM, Yasin NM. Hubungan antara efektivitas hemodialisis dengan kualitas hidup pasien penyakit ginjal kronis di Yogyakarta. J Farmasi Ilmu Kefarmasian Indones. 2021;8(1).

Hasan MN, Tirtana A. Relationship between biochemical marker and comorbidity with fatigue in patients with hemodialysis in Yogyakarta. J Kesehatan Madani Medika. 2019.

Sofue T, Nakagawa N, Kanda E, Nagasu H, Matsushita K, Nangaku M, et al. Prevalence of anemia in patients with chronic kidney disease in Japan: a nationwide, cross-sectional cohort study using data from the J-CKD-DB. PLoS One. 2020;15(7).

Chen YK, Chu CS, Niu SW, Lin HY, Yu PH, Shen FC, et al. The prognostic value of URR equals that of Kt/V for all-cause mortality in Taiwan after 10-year follow-up. Sci Rep. 2023;13(1).

Rohayati E. Hubungan antara adekuasi (kecukupan dosis HD) terhadap kualitas hidup pasien hemodialisis di RSUD Majalengka tahun 2022. J Kesehatan. 2023;9(1).

Dewi N, Setiyono E. Pengaruh dukungan keluarga terhadap kepatuhan dalam pembatasan asupan cairan pada pasien CKD yang menjalani terapi hemodialisa. J Ilmiah Kesehatan. 2022;14(2).

Dewi RAK, Karwati, Afreani D. Hubungan dukungan keluarga dengan kepatuhan pembatasan asupan cairan pada pasien gagal ginjal kronik di unit hemodialisa. J Health (Joh). 2023;10(2).

Koch B, Dolnik O, Filzmayer M, Becker S, Geiger H, Baer P. Fp217 Marburg virus and acute kidney injury. Nephrol Dial Transplant. 2018;33(11):2069.

Artiany S, Gamayana TAY. Gambaran komorbid pada pasien hemodialisis di RSAU Dresnawan Antariksa. J Keperawatan Cikini. 2021;2(2).

Sudiharto, Mardiyono, Arwani. Pengaturan quick of blood (QB) berdasarkan berat badan terhadap rasio reduksi ureum (RRU) pada pasien hemodialisis di RSUD Kota Semarang. J Kesehatan. 2014.

Hermansyah Y, Novidyawati F, Azis AM. Perbandingan kadar natrium pada pasien penyakit gagal ginjal kronik stadium V yang menggunakan hemodialyzer baru dan reuse. J Agromedicine Med Sci. 2020;6(1).

Abe M, Masakane I, Wada A, Nakai S, Nitta K, Nakamoto H. Dialyzer surface area is a significant predictor of mortality in patients on hemodialysis: a 3-year nationwide cohort study. Sci Rep. 2021;11(1).

DOI: https://doi.org/10.24198/ijpst.v12i2.50702