Activity of Lintut (Strobilanthes kalimantanensis) Leaves Essential Oil as Anti-inflammatory in Male Mice (Mus musculus)

Kartika Indah Susilowati; Wisnu Cahyo Prabowo; Islamudin Ahmad

doi:10.24198/ijpst.v6i1.53264

Activity of Lintut (Strobilanthes kalimantanensis) Leaves Essential Oil as Anti-inflammatory in Male Mice (Mus musculus)

Kartika Indah Susilowati, Wisnu Cahyo Prabowo, Islamudin Ahmad

Abstrak

Inflammation is a natural response of body cause by strange substances that can damage the body cells and tissues. Lintut (Strobilanthes kalimantanensis) is an endemic plant from West Kutai which is used as a respiratory-lozenges. Lintut leaves have a distinctive aroma and contain alkaloids, terpenoids and phenols. This research aims to determine its anti-inflammatory activity, the best dose, and effectiveness as an anti-inflammatory. This research uses the croton oil induction method which is applied topically to the ears of mice. Mices are grouped into 5 groups, concentrations of 5%, 10%, 15%, negative control (acetone), and positive control (diclofenac sodium cream 1%). The research results obtained from this research are the results of weighing the ear, macroscopic images and microscopic images. The results of the percent edema obtained showed that only at a concentration of 10% the essential oil of lintut leaves had anti-inflammatory activity, namely with a percent edema value of 26.48%. This concentration was then compared with 1% diclofenac sodium cream. The statistic results show a significant difference, this shows that the 10% concentration has good effectiveness as an anti-inflammatory.

Kata Kunci

Antiinflammatory, Essential Oil; Lintut (Strobilanthes kalimantanensis).

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/ijpst.v6i1.53264