Sistem Penghantaran Astaxanthin pada Sediaan Oral dan Topikal

Enricko Mohammad Rizaldy

doi:10.24198/ijpst.v12i1.54765

Sistem Penghantaran Astaxanthin pada Sediaan Oral dan Topikal

Enricko Mohammad Rizaldy

Abstrak

Astaxanthin adalah karotenoid teroksigenasi yang memiliki aktivitas antioksidan yang kuat. Aktivitas antioksidan astaxanthin 10 kali lebih tinggi dibandingkan karotenoid lainnya dan lebih dari 500 kali lebih efektif dibandingkan α-tokoferol. Aktivitas antioksidan yang kuat ini menyebabkan pemanfaatan astaxanthin secara luas dalam makanan, obat, suplemen makanan (nutraceuticals), kosmetik, dan pakan. Di balik manfaatnya yang besar, senyawa astaxanthin memiliki kekurangan yaitu kelarutannya yang rendah dalam air, ketidakstabilannya pada suhu tinggi, pH asam, oksigen atau cahaya dan bau/rasanya yang kuat. Bentuk sediaan yang banyak digunakan dalam pengobatan yang memanfaatkan astaxanthin adalah sediaan oral dan topikal. Literature review ini mengulas kemajuan terkini dalam pembuatan sediaan farmasi dengan komponen astaxanthin, yang dikembangkan untuk meningkatkan stabilitas dan kelarutannya dalam air, terutama pada sediaan oral dan topikal. Metode yang digunakan dalam penyusunan artikel riview ini adalah pencarian database melalui Scopus, PubMed, dan Google Scholar. Dari penelusuran literatur, diketahui bahwa sistem penghantaran baru yang dikembangkan untuk senyawa astaxanthin antara lain, liposom, nano partikel, sistem partikulat, kompleks inklusi, emulsi, dan film. Sistem tersebut terbukti mampu meningkatkan sifat astaxanthin, di antaranya adalah peningkatan stabilitas, potensi antioksidan, aktivitas biologis, pelepasan obat, dan perlindungan dari degradasi di saluran pencernaan.

Kata Kunci

astaxanthin; liposom; nanopartikel; oral; sediaan; topikal.

Teks Lengkap:

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Referensi

Presiden Republik Indonesia. Undang-Undang Republik Indonesia Nomor 32 Tahun 2014 tentang Kelautan. Jakarta (Indonesia): Presiden RI; 2014 hal. 4-6.

Bjørklund G, Gasmi A, Lenchyk L, et al. The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions. Molecules. 2022;27(21):7167. doi:10.3390/molecules27217167

da Silva FO, Tramonte VLCG, Parisenti J, Lima-Garcia JF, Maraschin M, da Silva EL. Litopenaeus vannamei muscle carotenoids versus astaxanthin: A comparison of antioxidant activity and in vitro protective effects against lipid peroxidation. Food Biosci. 2015;9:12-19. doi:10.1016/j.fbio.2014.11.001

Singh DP, Khattar JS, Rajput A, Chaudhary R, Singh R. High production of carotenoids by the green microalga Asterarcys quadricellulare PUMCC 5.1.1 under optimized culture conditions. PLoS One. 2019;14(9):e0221930. doi:10.1371/journal.pone.0221930

Fábryová T, Tůmová L, da Silva DC, et al. Isolation of astaxanthin monoesters from the microalgae Haematococcus pluvialis by high performance countercurrent chromatography (HPCCC) combined with high performance liquid chromatography (HPLC). Algal Res. 2020;49:101947. doi:10.1016/j.algal.2020.101947

Montero P, Calvo MM, Gómez-Guillén MC, Gómez-Estaca J. Microcapsules containing astaxanthin from shrimp waste as potential food coloring and functional ingredient: Characterization, stability, and bioaccessibility. LWT. 2016;70:229-236. doi:10.1016/j.lwt.2016.02.040

Morales E, Burgos-Díaz C, Zúñiga RN, Jorkowski J, Quilaqueo M, Rubilar M. Influence of O/W emulsion interfacial ionic membranes on the encapsulation efficiency and storage stability of powder microencapsulated astaxanthin. Food and Bioproducts Processing. 2021;126:143-154. doi:10.1016/j.fbp.2020.12.014

Shen Q, Quek SY. Microencapsulation of astaxanthin with blends of milk protein and fiber by spray drying. J Food Eng. 2014;123:165-171. doi:10.1016/j.jfoodeng.2013.09.002

Saechio S, Akanitkul P, Thiyajai P, et al. Astaxanthin-Loaded Pickering Emulsions Stabilized by Nanofibrillated Cellulose: Impact on Emulsion Characteristics, Digestion Behavior, and Bioaccessibility. Polymers (Basel). 2023;15(4):901. doi:10.3390/polym15040901

Patil AD, Kasabe PJ, Dandge PB. Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin. Nat Prod Bioprospect. 2022;12(1):25. doi:10.1007/s13659-022-00347-y

Villaró S, Ciardi M, Morillas-España A, Sánchez-Zurano A, Acién-Fernández G, Lafarga T. Microalgae Derived Astaxanthin: Research and Consumer Trends and Industrial Use as Food. Foods. 2021;10(10):2303. doi:10.3390/foods10102303

Visioli F, Artaria C. Astaxanthin in cardiovascular health and disease: mechanisms of action, therapeutic merits, and knowledge gaps. Food Funct. 2017;8(1):39-63. doi:10.1039/C6FO01721E

Pardina NA, Setyowatie L. Tinjauan Literatur : Peran Astaxanthin pada Luka Bakar. Majalah Kesehatan. 2020;7(4):273-284. doi:10.21776/ub.majalahkesehatan.2020.007.04.7

Karpiński TM, Ożarowski M, Alam R, Łochyńska M, Stasiewicz M. What Do We Know about Antimicrobial Activity of Astaxanthin and Fucoxanthin? Mar Drugs. 2021;20(1):36. doi:10.3390/md20010036

Santonocito D, Raciti G, Campisi A, et al. Astaxanthin-Loaded Stealth Lipid Nanoparticles (AST-SSLN) as Potential Carriers for the Treatment of Alzheimer’s Disease: Formulation Development and Optimization. Nanomaterials. 2021;11(2):391. doi:10.3390/nano11020391

Ito N, Seki S, Ueda F. The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2018;10(7):817. doi:10.3390/nu10070817

Sztretye M, Dienes B, Gönczi M, et al. Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging. Oxid Med Cell Longev. 2019:1-14. doi:10.1155/2019/3849692

Laja RSP. Astaxanthin untuk Kesehatan Kardiovaskular. Jurnal Penelitian Perawat Profesional. 2021;3(2):243-252. doi:10.37287/jppp.v3i2.259

Landon R, Gueguen V, Petite H, Letourneur D, Pavon-Djavid G, Anagnostou F. Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications. Mar Drugs. 2020;18(7):357. doi:10.3390/md18070357

Islam MdA, Al Mamun MdA, Faruk Md, et al. Astaxanthin ameliorates hepatic damage and oxidative stress in carbon tetrachloride-administered rats. Pharmacognosy Res. 2017;9(5):84. doi:10.4103/pr.pr_26_17

Zhao W, Wei HL, Chen MD, Yao R, Wang ZQ, Niu J. Effects of synthetic astaxanthin and Haematococcus pluvialis on growth, antioxidant capacity, immune response, and hepato-morphology of Oncorhynchus mykiss under cage culture with flowing freshwater. Aquaculture. 2023;562:738860. doi:10.1016/j.aquaculture.2022.738860

Chen Q, Huang S, Dai J, et al. Effects of Synthetic Astaxanthin on the Growth Performance, Pigmentation, Antioxidant Capacity, and Immune Response in Black Tiger Prawn (Penaeus monodon). Aquac Nutr. 2023;2023:1-14. doi:10.1155/2023/6632067

Loyd V. Allen J, Nicholas G. Popovich, Howard C. Ansel. Bentuk Sediaan Farmasetis Dan Sistem Penghantaran Obat. 9th ed. (Hafshah Nurul Afifah, Tri Rahayu Ningsih, eds.). Penerbit Buku Kedokteran EGC; 2022.

Ajazuddin, Alexander A, Khichariya A, et al. Recent expansions in an emergent novel drug delivery technology: Emulgel. Journal of Controlled Release. 2013;171(2):122-132. doi:10.1016/j.jconrel.2013.06.030

Wati Eliana Putri, Metha Anung Anindhita. Optimasi formula gel ekstrak etanol buah kapulaga dengan kombinasi gelling agent HPMC dan Natrium Alginat menggunakan simplex lattice design . Jurnal Ilmiah Farmasi (Scientific Journal of Pharmacy) Special Edition . Published online 2022:107-120.

Lima SGM, Freire MCLC, Oliveira V da S, Solisio C, Converti A, de Lima ÁAN. Astaxanthin Delivery Systems for Skin Application: A Review. Mar Drugs. 2021;19(9):511. doi:10.3390/md19090511

Chang HI, Shao CW, Huang E, Huang KY. Development of Astaxanthin-Loaded Nanosized Liposomal Formulation to Improve Bone Health. Pharmaceuticals. 2022;15(4):490. doi:10.3390/ph15040490

Lee HS, Sung DK, Kim SH, et al. Controlled release of astaxanthin from nanoporous silicified-phospholipids assembled boron nitride complex for cosmetic applications. Appl Surf Sci. 2017;424:15-19. doi:10.1016/j.apsusc.2017.03.036

Costa R, Santos L. Delivery systems for cosmetics - From manufacturing to the skin of natural antioxidants. Powder Technol. 2017;322:402-416. doi:10.1016/j.powtec.2017.07.086

Callender SP, Mathews JA, Kobernyk K, Wettig SD. Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. Int J Pharm. 2017;526(1-2):425-442. doi:10.1016/j.ijpharm.2017.05.005

Nastiti C, Ponto T, Abd E, Grice J, Benson H, Roberts M. Topical Nano and Microemulsions for Skin Delivery. Pharmaceutics. 2017;9(4):37. doi:10.3390/pharmaceutics9040037

Zhou Q, Xu J, Yang S, et al. The Effect of Various Antioxidants on the Degradation of O/W Microemulsions Containing Esterified Astaxanthins from <i>Haematococcus pluvialis</i> J Oleo Sci. 2015;64(5):515-525. doi:10.5650/jos.ess14264

Rai K, Chhanwal N, Shah NN, Singhal RS. Encapsulation of ginger oleoresin in co-crystallized sucrose: development, characterization and storage stability. Food Funct. 2021;12(17):7964-7974. doi:10.1039/D1FO00565K

Shanmugapriya K, Kim H, Saravana PS, Chun BS, Kang HW. Astaxanthin-alpha tocopherol nanoemulsion formulation by emulsification methods: Investigation on anticancer, wound healing, and antibacterial effects. Colloids Surf B Biointerfaces. 2018;172:170-179. doi:10.1016/j.colsurfb.2018.08.042

Higuera-Ciapara I, Felix-Valenzuela L, Goycoolea FM, Argüelles-Monal W. Microencapsulation of astaxanthin in a chitosan matrix. Carbohydr Polym. 2004;56(1):41-45. doi:10.1016/j.carbpol.2003.11.012

Lin SF, Chen YC, Chen RN, et al. Improving the Stability of Astaxanthin by Microencapsulation in Calcium Alginate Beads. PLoS One. 2016;11(4):e0153685. doi:10.1371/journal.pone.0153685

Hu F, Liu W, Yan L, Kong F, Wei K. Optimization and characterization of poly(lactic-co-glycolic acid) nanoparticles loaded with astaxanthin and evaluation of anti-photodamage effect in vitro. R Soc Open Sci. 2019;6(10):191184. doi:10.1098/rsos.191184

Carneiro S, Costa Duarte F, Heimfarth L, et al. Cyclodextrin–Drug Inclusion Complexes: In Vivo and In Vitro Approaches. Int J Mol Sci. 2019;20(3):642. doi:10.3390/ijms20030642

Kathe K, Kathpalia H. Film forming systems for topical and transdermal drug delivery. Asian J Pharm Sci. 2017;12(6):487-497. doi:10.1016/j.ajps.2017.07.004

Veeruraj A, Liu L, Zheng J, Wu J, Arumugam M. Evaluation of astaxanthin incorporated collagen film developed from the outer skin waste of squid Doryteuthis singhalensis for wound healing and tissue regenerative applications. Materials Science and Engineering: C. 2019;95:29-42. doi:10.1016/j.msec.2018.10.055

Kaur R, Arora S, Goswami M. Formulation development and evaluation of Transdermal patch of Astaxanthin. Mater Today Proc. Published online November 2022. doi:10.1016/j.matpr.2022.11.119

Stachowiak B, Szulc P. Astaxanthin for the Food Industry. Molecules. 2021;26(9):2666. doi:10.3390/molecules26092666

Date AA, Hanes J, Ensign LM. Nanoparticles for oral delivery: Design, evaluation and state-of-the-art. Journal of Controlled Release. 2016;240:504-526. doi:10.1016/j.jconrel.2016.06.016

Martínez-Álvarez Ó, Calvo MM, Gómez-Estaca J. Recent Advances in Astaxanthin Micro/Nanoencapsulation to Improve Its Stability and Functionality as a Food Ingredient. Mar Drugs. 2020;18(8):406. doi:10.3390/md18080406

Sangsuriyawong A, Limpawattana M, Siriwan D, Klaypradit W. Properties and bioavailability assessment of shrimp astaxanthin loaded liposomes. Food Sci Biotechnol. 2019;28(2):529-537. doi:10.1007/s10068-018-0495-x

Domínguez-Hernández, CR; García-Alvarado, MA; García-Galindo, HS; Salgado-Cervantes, MA; Beristain. Stabilitas CI, Aktivitas Antioksidan dan Bioavaibilitas Nano Emulsifikasi Astaxanthin. Pendeta Mex Ing Química. 2016;15:457-468.

Affandi MMRMM, Julianto T, Majeed ABA. Enhanced Oral Bioavailability of Astaxanthin with Droplet Size Reduction. Food Sci Technol Res. 2012;18(4):549-554. doi:10.3136/fstr.18.549

Wang T, Hu Q, Lee JY, Luo Y. Solid Lipid–Polymer Hybrid Nanoparticles by In Situ Conjugation for Oral Delivery of Astaxanthin. J Agric Food Chem. 2018;66(36):9473-9480. doi:10.1021/acs.jafc.8b02827

Li M, Zahi MR, Yuan Q, Tian F, Liang H. Preparation and stability of astaxanthin solid lipid nanoparticles based on stearic acid. European Journal of Lipid Science and Technology. 2016;118(4):592-602. doi:10.1002/ejlt.201400650

DOI: https://doi.org/10.24198/ijpst.v12i1.54765