Penggunaan Tradisional, Aktivitas Farmakologis dan Senyawa Bioaktif Mangrove yang Tumbuh di Teluk Balikpapan, Kalimantan Timur

Nurul Muhlisa Mus; Fajar Prasetya; Mentarry Bafadal; Raisa Fadilla

doi:10.24198/ijpst.v6i1.55879

Penggunaan Tradisional, Aktivitas Farmakologis dan Senyawa Bioaktif Mangrove yang Tumbuh di Teluk Balikpapan, Kalimantan Timur

Nurul Muhlisa Mus, Fajar Prasetya, Mentarry Bafadal, Raisa Fadilla

Abstrak

Mangrove adalah tanaman yang dapat bertahan di lingkungan dengan kadar garam tinggi dan membentuk komunitas serta ekosistem yang unik. Untuk bertahan dalam kondisi yang sulit, mangrove diperkirakan menghasilkan berbagai senyawa fitokimia. Selama bertahun-tahun, masyarakat telah banyak memanfaatkan tanaman ini untuk keperluan pengobatan dan kebutuhan tradisional. Beberapa genus mangrove memiliki efikasi yang berpotensi tinggi untuk dikembangkan. Teluk Balikpapan adalah salah satu kawasan di Kalimantan Timur yang memiliki spesies tanaman mangrove yang beragam. Kajian ini membahas tentang penggunaan empiris, senyawa bioaktif serta aktivitas farmakologis yang dihasilkan oleh tanaman obat mangrove yang tumbuh di Teluk Balikpapan. Diharapkan kajian ini dapat menjadi cara untuk menjamin ketahanan obat-obatan di Indonesia khususnya di Teluk Balikpapan pada masa yang akan datang.

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Referensi

FAO. 2023. The world’s mangroves 2000–2020. Rome. https://doi.org/10.4060/cc7044en

FAO. 2020. Global Forest Resources Assessment 2020: Main report. Rome. https://www.fao.org/documents/card/en/c/ca9825en

Beys-da-Silva, W. O., Santi, L., & Guimarães, J. A. (2014). Mangroves: A Threatened Ecosystem Under-Utilized as a Resource for Scientific Research. In Journal of Sustainable Development (Vol. 7, Issue 5). Canadian Center of Science and Education. https://doi.org/10.5539/jsd.v7n5p40

Kementrian lingkungan hidup dan kehutanan. 2022. (Diakses dari https://kanalkomunikasi.pskl.menlhk.go.id/mangrove-indonesia-untuk-dunia/)

Spalding, M., M. Kainuma, and L. Collins (2010) World Atlas of Mangrove. Earthscan. London, UK

Pambudi, D. B., & Haryoto, H. (2022). Efektivitas Farmakologi Senyawa Aktif Tumbuhan Mangrove Yang Hidup Di Indonesia. Jurnal Ilmiah Kesehatan, 15(1), 39-57.

Patra, J. K., Mishra, R. R., & Thatoi, H. (Eds.). (2020). Biotechnological utilization of mangrove resources. Academic Press.

Kurniawan, R., Azis, S., Maulana, S., Ashari, A., Prasetyo, B. A., Suhartati, T., & Sukrasno, S. (2022). The cytotoxicity studies of phytosterol discovered from Rhizophora apiculata against three human cancer cell lines. Journal of Applied Pharmaceutical Science, 13(1), 156-162.

Ramya, R., Kamoona, S., Hatta, F. A. M., Sulaiman, W. S. H. W., Latiff, N. H. M., & Othman, R. (2023). A Study on an Active Functional Group and Antimicrobial Properties from Rhizophora apiculata Extracts Used in Traditional Malay as Medicine. Malaysian Applied Biology, 52(4), 153-160.

Acharya, S., Jali, P., Pradhan, M., Pradhan, C., & Mohapatra, P. K. (2023). Antimicrobial and Antioxidant Property of a True Mangrove Rhizophora apiculata Bl. Chemistry & Biodiversity, 20(9), e202201144.

Sormin, R. B. D., Nendissa, D. M., Mailoa, M. N., Rieuwpassa, F., & Wenno, M. R. (2021, June). Antibacterial activity of Rhizophora apiculata extract originated from Inner Ambon Bay against selected pathogen bacteria. In IOP Conference Series: Earth and Environmental Science (Vol. 797, No. 1, p. 012017). IOP Publishing.

Kumar, H. S., & Abirami Arthanari, D. S. (2023). Bioactive Compounds from Rhizophora Apiculata and Their Anti-Diabetic and Anti-Coagulant Properties. Chelonian Research Foundation, 18(2), 2089-2099.

Mustofa, S., Adjeng, A. N. T., Kurniawaty, E., Ramadhita, L., & Tamara, T. (2024). Influence of Rhizophora apiculata barks extract on Cholesterol, Triglyceride, LDL, and HDL Levels of Rattus norvegicus (Sprague Dawley) fed high-cholesterol diet. Research Journal of Pharmacy and Technology, 17(1), 396-400.

Sadeer, N. B., Rocchetti, G., Senizza, B., Montesano, D., Zengin, G., Uysal, A., ... & Mahomoodally, M. F. (2019). Untargeted metabolomic profiling, multivariate analysis and biological evaluation of the true mangrove (Rhizophora mucronata Lam.). Antioxidants, 8(10), 489.

Youssef, A. M., Maaty, D. A., & Al-Saraireh, Y. M. (2022). Phytochemistry and anticancer effects of mangrove (Rhizophora mucronata lam.) leaves and stems extract against different cancer cell lines. Pharmaceuticals, 16(1), 4.

Sachithanandam, V., Lalitha, P., Parthiban, A., Muthukumaran, J., Jain, M., Misra, R., ... & Ramesh, R. (2022). A comprehensive in silico and in vitro studies on quinizarin: A promising phytochemical derived from Rhizophora mucronata Lam. Journal of Biomolecular Structure and Dynamics, 40(16), 7218-7229.

Asbin Mary, X., Yacoob, S. A. M., Venkatraman, A., Packiasamy, R., Moovendhan, M., Gnanadesigan, M., & Nagarajan, Y. (2023). Anticancer Activity of Rhizophora mucronata Leaves Extract on Sprague–Dawley Rats: In Vivo Model.

Mitra, S., Islam, F., Das, R., Urmee, H., Akter, A., Idris, A. M., ... & Emran, T. B. (2022). Pharmacological potential of Avicennia alba leaf extract: an experimental analysis focusing on antidiabetic, anti-inflammatory, analgesic, and antidiarrheal activity. BioMed Research International, 2022.

Mazlan, N. W., Clements, C., & Edrada-Ebel, R. (2020). Targeted isolation of anti-trypanosomal naphthofuran-quinone compounds from the mangrove plant Avicennia lanata. Marine drugs, 18(12), 661.

Jamili, J., Armid, A., Harlis, W., & Reininggrum, F. (2023, May). Morphology of epididymis spermatozoa and spermatogenesis of mice (Mus musculus L.) after treated by mangrove extract of Avicennia lanata ridley. In AIP Conference Proceedings (Vol. 2704, No. 1). AIP Publishing.

Nasution, R., Jeon, Y., Fadillah, H., Bahi, M., & Marianne, M. (2024). Phytochemistry and Antidiabetic Activity from the Leaf Midrib of Nypa fruticans Wurm. Indonesian Journal of Chemistry.

Qurrohman, T., Hasibuan, P. A. Z., & Basyuni, M. (2020). Development of chemotherapeutic in mangrove leaves. International Journal of Scientific and Technology Research, 9(4), 143-145.

Rusyiana, R., Lestarini, I. A., Hamdin, C. D., & Muliasari, H. (2021). Jurnal-Anticoagulant Activity of Mangrove (Avicennia alba) Leaves Extract in Vitro. Indonesian Journal of Marine Sciences, 26(2), 110-116.

Sultana, S., Biswas, R., & Islam, K. M. D. (2022). The Phytochemical Screening and Anti-cancer activity of Ethanolic Extracts of Selected Mangrove Plants. Pharmaceutical and Biomedical Research.

Eswaraiah, G., Peele, K. A., Krupanidhi, S., Kumar, R. B., & Venkateswarulu, T. C. (2020). Identification of bioactive compounds in leaf extract of Avicennia alba by GC-MS analysis and evaluation of its in-vitro anticancer potential against MCF7 and HeLa cell lines. Journal of King Saud University-Science, 32(1), 740-744.

Keerthi, R. R., Baskar, K., Mavishna, M., & Johnson, A. (2022). Antibacterial and antioxidant activity of mangrove plant (Avicennia Marina) extract against some specific oral pathogens. International Journal of Health Sciences, (III), 1348-1355.

Febriani, A. K., Ismiyarto, I., & Anam, K. (2020). Total phenolic and coumarin content, antioxidant activity of leaves, fruits, and stem barks of grey mangrove (Avicennia marina). Jurnal Kimia Sains dan Aplikasi, 23(2), 34-38.

Okla, M. K., Alamri, S. A., Alatar, A. A., Hegazy, A. K., Al-Ghamdi, A. A., Ajarem, J. S., ... & Abdel-Maksoud, M. A. (2019). Antioxidant, hypoglycemic, and neurobehavioral effects of a leaf extract of Avicennia marina on autoimmune diabetic mice. Evidence-Based Complementary and Alternative Medicine, 2019.

Belhadj-Salah, K., Sheikh, H. M., Al-Hasawi, Z. M., Selim, E. M., & Touliabah, H. E. (2022). In vitro antifungal and antibacterial potentials of organic extracts of Avicennia marina collected from Rabigh Lagoon, Red Sea Coasts in Saudi Arabia. Brazilian Journal of Biology, 82, e265038.

Albinhassan, T. H., Saleh, K. A., Barhoumi, Z., Alshehri, M. A., & Al-Ghazzawi, A. M. (2021). Anticancer, anti-proliferative activity of Avicennia marina plant extracts. Journal of Cancer Research and Therapeutics, 17(4), 879-886.

Biswas, B., Golder, M., Abid, M. A., Mazumder, K., & Sadhu, S. K. (2021). Terpenoids enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice. Heliyon, 7(7).

Ramadhan, R., Phuwapraisirisan, P., Kusuma, I. W., & Amirta, R. (2020). Ethnopharmacological evaluation of selected east Kalimantan flora for diabetes therapy: The isolation of lupane triterpenoids as α-glucosidase inhibitors from ceriops tagal (perr) cb robb. Rasayan Journal of Chemistry, 13(3), 1727-1734.

Sachithanandam, V., Parthiban, A., Lalitha, P., Muthukumaran, J., Jain, M., Elumalai, D., ... & Ramachandran, R. (2022). Biological evaluation of gallic acid and quercetin derived from Ceriops tagal: insights from extensive in vitro and in silico studies. Journal of Biomolecular Structure and Dynamics, 40(4), 1490-1502.

Ahad, M. F., Zilani, M. N. H., Akter, A., Md, A. S., Nasrullah, U. K. K., Biswas, N. N., ... & Bokshi, B. (2021). Comparative pharmacological potential of Ceriops decandra (Griff.) and Ceriops tagal Linn: medicinal plants of the Sundarbans. Journal of Medicinal Plants, 9(4), 14-23.

Shamsuzzaman, M., Kalaiselvi, K., & Prabakaran, M. (2021). Evaluation of antioxidant and anticorrosive activities of Ceriops tagal plant extract. Applied Sciences, 11(21), 10150.

Canusa, B. S., Lawag, I., Villaflores, O. B., Wagh, V. D., Korinek, M., Tsai, Y. H., ... & Aguinaldo, A. M. (2022). α-Glucosidase Inhibitors from the Bark Extract of Ethno-Antidiabetic Ceriops tagal (Perr.) CB Rob. Philippine Journal of Science, 151(S1), 25-60.

Zhang, X., Li, G., Deng, Q., Xu, Z., Cen, J., & Xu, J. (2021). Vomifoliol isolated from mangrove plant Ceriops tagal inhibits the NFAT signaling pathway with CN as the target enzyme in vitro. Bioorganic & Medicinal Chemistry Letters, 48, 128235.

Istiqomah, M. A., Hasibuan, P. A. Z., Nuryawan, A., Sumaiyah, S., Siregar, E. S., & Basyuni, M. (2021). The anticancer compound dolichol from Ceriops tagal and Rhizophora mucronata leaves regulates gene expressions in WiDr colon cancer. Sains Malaysiana, 50(1), 181-189.

Mayanti, T., Harneti, D., Maharani, R., Farabi, K., Herlina, T., Supratman, U., ... & Chakthong, S. (2023). Sesquiterpenoids and sesquiterpenoid dimers from the stem bark of Dysoxylum parasiticum (osbeck) kosterm. Phytochemistry, 205, 113477.

Hadrian, E., Raharja, G. L., Anvolia, K., & Insani, R. M. S. (2023). Identification, Extraction, Phytochemical Screening and Study of Antimicrobial Activities of Native Papuan Tree Bark Extract: Dysoxylum Alliaceum and Aglaia sp. Indonesian Journal of Life Sciences, 48-58.

Mayanti, T., Maharani, R., Fajriah, S., Kabayama, K., Shimoyama, A., Manabe, Y., ... & Supratman, U. (2023). Dysoticans F–H: three unprecedented dimeric cadinanes from Dysoxylum parasiticum (Osbeck) Kosterm. stem bark. RSC advances, 13(14), 9370-9376.

Riyadi, S. A., Naini, A., Mayanti, T., Farabi, K., Lesmana, R., Azmi, M. N., ... & Supratman, U. (2024). Targeted triterpenoids from Dysoxylum alliaceum stem barks as cytotoxic agents in human cancer and normal cells.

Meilanie, S. R., Mayanti, T., Nurlelasari, N., Huspa, D. H. P., Maharani, R., Zainuddin, A., ... & Al Anshori, J. (2022). Triterpenoids from Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells. Indonesian Journal of Chemistry, 22(4), 1107-1115.

Xie, Q., Shama, R., Yu, J., Bao, Q., Su, H., Liu, B., & Borjigidai, A. (2024). Ethnobotanical study of Zhuang medicinal herbs of Ardisia: variety systematization, traditional uses, phytochemistry, pharmacology, clinical application, and toxicity. Journal of Pharmacy and Pharmacology, rgad119.

Fitriansyah, S. N., Fidrianny, I., & Hartati, R. (2021). Pharmacological activities and phytochemical compounds: Overview of Pouteria genus. Pharmacognosy Journal, 13(2).

Karmakar, U. K., Paul, A., Kundu, P., & Paul, P. P. (2023). Exploration of Anthelmintic, Blood Coagulant, Diuretic and Laxative Activities of Different Solvent Fractions of Flagellaria Indica Leaves. Jordan Journal of Pharmaceutical Sciences, 16(3), 655-670.

Karmakar, U. K., Paul, A., & Bokshi, B. (2021). Investigation of antidiarrheal, analgesic, antidiabetic and cytotoxic activities of the aerial parts of Flagellaria indica (flagellariaceae).

Acharya, S.; Patra, D.K.; Pradhan, C.; Mohapatra, P.K. (2020). Anti-bacterial, anti-fungal and anti-oxidative properties of different extracts of Bruguiera gymnorrhiza L. (Mangrove). Eur. J. Integr. Med. 36, 101140.

Lin, Y., Zheng, X., Chen, J., Luo, D., Xie, J., Su, Z., ... & Sun, Z. (2020). Protective effect of Bruguiera gymnorrhiza (L.) Lam. fruit on dextran sulfate sodium-induced ulcerative colitis in mice: Role of Keap1/Nrf2 pathway and gut microbiota. Frontiers in Pharmacology, 10, 1602.

Zhang, X., Mai, J. H., Gao, Z. W., & Wang, L. L. (2022). Bruguiera gymnorrhiza (L.) Lam. Fruit Accelerates Healing in Gastric Injury via the Regulation of the NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine.

Eldeen, I. M., Ringe, J., & Noraznawati, I. (2019). Inhibition of pro-inflammatory enzymes and growth of an induced rheumatoid arthritis synovial fibroblast by Bruguiera cylindrica. International Journal of Pharmacology, 15(8), 916-925.

Golder, M., Sadhu, S. K., Biswas, B., & Islam, T. (2020). Comparative pharmacologic profiles of leaves and hypocotyls of a mangrove plant: Bruguiera gymnorrhiza. Advances in Traditional Medicine, 20, 395-403.

Gayen, S., Jana, S., Das Gupta, B., Ghosh, A., Kar, A., Bala, A., ... & Haldar, P. K. (2024). Exploration of anti-diabetic activity and metabolite profiling of Bruguiera cylindrica (l.) Bl.—in vivo anti-diabetic activity, exploration of molecular mechanism, and network pharmacological analysis. Journal of Pharmacy and Pharmacology, rgae030.

Singh, P., Ahmed, N., Shenoy, A. 2023. Antimicrobial Activity of Bruguiera cylindrica against Oral Pathogenic Bacteria. Journal of Chemical Health Risks. Vol 13 No. 4

Yami, A. C. L., Batubara, I., & Audah, K. A. (2020). Antioxidant and antibacterial activity of mangrove Brugueira gymnorrhiza stem extracts against pathogenic bacteria Vibrio cholerae. Acta Biochimica Indonesiana, 3(2), 53-61.

Luo, X., Chen, X., Zhang, L., Liu, B., Xie, L., Ma, Y., ... & Jin, X. (2024). Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review. Marine Drugs, 22(4), 158.

Karim, M. A., Islam, M. A., Islam, M. M., Rahman, M. S., Sultana, S., Biswas, S., ... & Hasan, M. N. (2020). Evaluation of antioxidant, anti-hemolytic, cytotoxic effects and anti-bacterial activity of selected mangrove plants (Bruguiera gymnorrhiza and Heritiera littoralis) in Bangladesh. Clinical Phytoscience, 6, 1-12.

Le Nguyen, T. T., Bui, T. T., Nguyen, P. K. P., Tran, C. M., Phan, T. D. C., & Nguyen, T. T. (2020). Two new compounds from leaves of Bruguiera cylindrica (L.) Blume with the in vitro α-glucosidase inhibitory activity. Science and Technology Development Journal, 23(4), 800-807.

Bui, T. T., Nguyen, K. P. T., Nguyen, P. P. K., Le, D. T., & Nguyen, T. L. T. (2022). Anti-inflammatory and α-glucosidase inhibitory activities of chemical constituents from Bruguiera parviflora leaves. Journal of Chemistry, 2022.

Tung, B. T., & Le Thuy, N. T. (2022). Antioxidant activity of isolated compounds from ethyl acetate extract of Bruguiera parviflora. HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE-ENGINEERING AND TECHNOLOGY, 12(2), 42-49.

Abubakar, S., Al‐Mansoub, M. A., Murugaiyah, V., & Chan, K. L. (2019). The phytochemical and anti‐inflammatory studies of Dillenia suffruticosa leaves. Phytotherapy research, 33(3), 660-675.

Syafriana, V., Febriani, A., & Hamida, F. (2021). Antimicrobial activity of ethanolic extract of sempur (Dillenia suffruticosa (Griff.) Martelli) leaves against pathogenic microorganisms. Borneo Journal of Pharmacy, 4(2), 135-144.

Muharini, R., Lestari, I., & Masriani, M. (2021). Antioxidant-phenolic content correlation of phenolics rich fractions from Dillenia suffruticosa wood bark. Pharmaciana, 11(2), 283-292.

Abubakar, S., Khor, B. K., Khaw, K. Y., Murugaiyah, V., & Chan, K. L. (2021). Cholinesterase inhibitory potential of Dillenia suffruticosa chemical constituents and protective effect against Aβ− induced toxicity in transgenic Caenorhabditis elegans model. Phytomedicine Plus, 1(1), 100022.

Yakop, F., Hamid, M. H. S. A., Ahmad, N., Majid, M. A., Pillai, M. K., & Taha, H. (2020). Phytochemical screening, antioxidant and antibacterial activities of extracts and fractions of Dillenia suffruticosa leaves. Malaysian Applied Biology, 49(1), 121-130.

Shah, M. D., Venmathi Maran, B. A., Iqbal, M., Ching, F. F., Mohamad Lal, M. T., Binti Othman, R., & Shapawi, R. (2020). Antiparasitic activity of the medicinal plant Dillenia suffruticosa against the marine leech Zeylanicobdella arugamensis (Hirudinea) and its phytochemical composition. Aquaculture research, 51(1), 215-221.

Islam, M. A., Zilani, M. N. H., Biswas, P., Khan, D. A., Rahman, M. H., Nahid, R., ... & Hasan, M. N. (2022). Evaluation of in vitro and in silico anti-inflammatory potential of some selected medicinal plants of Bangladesh against cyclooxygenase-II enzyme. Journal of Ethnopharmacology, 285, 114900.

Yazan, L. S., Roslie, S. H., Ali, R. M., Khaidi, A. A. S. M., Sze, O. Y., Ansar, F. H. Z., ... & Gopalsamy, B. (2019). Dillenia suffruticosa dichloromethane root extract reduced metastasis of 4T1 cells to the liver and heart without causing toxicity in female BALB/C mice. Malaysian Journal of Medicine and Health Sciences, 15(SP2), 25-32.

Syahira, R. H. (2024). ANTICANCER ACTIVITY OF SIMPOR (Dillenia suffruticosa Martelli) LEAF EXTRACTS FROM BELITUNG AGAINST HeLa CERVICAL CANCER CELLS (Doctoral dissertation, UNIVERSITAS NEGERI JAKARTA).

Fadly, D. (2020). α-Glucosidase Inhibitory Activity of Ethanol Extract Obtained from Dillenia suffruticosa and Pycnarrhena cauliflora. Journal of Global Pharma Technology, 12(02), 881-887.

Lin, G., Li, M., Xu, N., Wu, X., Liu, J., Wu, Y., ... & Su, Z. (2020). Anti-inflammatory effects of Heritiera littoralis fruits on dextran sulfate sodium-(DSS-) induced ulcerative colitis in mice by regulating gut microbiota and suppressing NF-κB pathway. BioMed Research International, 2020.

FITRI, Y., YUSNI, Y., SURYADI, T., & MUDATSIR, M. (2023). Characteristic and bioactivities value of Nypa fruticans from coastal area in West Aceh District, Indonesia as a candidate antidiabetic agent. Biodiversitas: Journal of Biological Diversity, 24(10).

Bernardo, J., Abata, R., Raymundo, R. E., & Capinpin Jr, E. F. (2022). Phytochemical Screening and In-Vitro Antibacterial Activity of Nipa (Nypa fruticans) Methanolic Leaves Extract Against Bacteria (Streptococcus agalactiae). PSU Journal of Natural and Allied Sciences, 6(1), 16-29.

Sukairi, A. H., Sabri, W. M. A. W., Yusop, S. A. T. W., & Asaruddin, M. R. (2019). Phytochemical screening, antidiabetic and antioxidant properties of Nypa frutican sap. Materials Today: Proceedings, 19, 1738-1744.

Senghoi, W., & Klangbud, W. K. (2021). Antioxidants, inhibits the growth of foodborne pathogens and reduces nitric oxide activity in LPS-stimulated RAW 264.7 cells of nipa palm vinegar. PeerJ, 9, e12151.

Sudirman, S., Wardana, A. K., Herpandı, H., Widiastuti, I., Sarı, D. I., & Janna, M. (2024). Antioxidant activity of polyphenol compounds extracted from Nypa fruticans Wurmb. (Nipa palm) fruit husk with different ethanol concentration. International Journal of Secondary Metabolite, 11(2), 355-363.

Kang, M. S., & Hyun, K. Y. (2020). Antinociceptive and anti-inflammatory effects of Nypa fruticans wurmb by suppressing TRPV1 in the sciatic neuropathies. Nutrients, 12(1), 135.

Chatatikun, M., & Kwanhian, W. (2020). Phenolic profile of nipa palm vinegar and evaluation of its antilipidemic activities. Evidence-Based Complementary and Alternative Medicine, 2020.

Istiqomah, M. A., Hasibuan, P. A. Z., Sumaiyah, S., Yusraini, E., Oku, H., & Basyuni, M. (2020). Anticancer effects of polyisoprenoid from Nypa fruticans leaves by controlling expression of p53, EGFR, PI3K, AKT1, and mTOR genes in colon cancer (WiDr) cells. Natural product communications, 15(4), 1934578X20918412.

Liang, X., Niu, P., Li, J., Guan, X., Zhang, Y., & Li, J. (2023). Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand. Molecules, 28(4), 1658.

Illian, D. N., Hasibuan, P. A. Z., Sumardi, S., Nuryawan, A., Wati, R., & Basyuni, M. (2019). Anticancer activity of polyisoprenoids from Avicennia alba Blume. in widr cells. Iranian Journal of Pharmaceutical Research: IJPR, 18(3), 1477.

Ramanathan, T. (2000). Studies on medicinal plants of Parangipettai coast (Southeast coast of India) (Doctoral dissertation, Annamalai University).

Rame, M. M. T., & Mbulang, Y. K. (2022). Antidiabetic Activity of Ethanolic Extract of Pandan Tikar (Pandanus tectorius) on Alloxan-Induced Diabetic White Male Rats. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 8(1), 41-51.

Heryanto, R., Putra, C. A., Khalil, M., Rafi, M., Putri, S. P., Karomah, A. H., & Batubara, I. (2023). Antioxidant activity and metabolite profiling of Xylocarpus granatum extracts using gas chromatography–mass spectrometry. Metabolites, 13(2), 156.

Andriani, Y., Ramli, N. M., Syamsumir, D. F., Kassim, M. N. I., Jaafar, J., Aziz, N. A., ... & Mohamad, H. (2019). Phytochemical analysis, antioxidant, antibacterial and cytotoxicity properties of keys and cores part of Pandanus tectorius fruits. Arabian Journal of Chemistry, 12(8), 3555-3564.

Sundus, S., Hira, K., Sohail, N., Habiba, Tariq, A., Ara, J., ... & Ehteshamul-Haque, S. (2021). Protective role of Pandanus tectorius Parkinson ex Du Roi in diabetes, hyperlipidemia, liver and kidney dysfunction in alloxan diabetic rats. Clinical Phytoscience, 7(1), 48.

Wijaya, M. D., Indraningrat, A. A. G., & Kirtanayasa, I. G. Y. A. (2023). Phytochemicals and Larvicidal Activity of Sonneratia alba Root Extracts from Ngurah Rai Mangrove Forest, Denpasar-Bali. Biology, Medicine, & Natural Product Chemistry, 12(2), 499-505.

Patel, S. S., & Savjani, J. K. (2015). Systematic review of plant steroids as potential antiinflammatory agents: Current status and future perspectives. The journal of phytopharmacology, 4(2), 121-125.

Surya, P. R. A., Wijaya, M. D., & Udiyani, D. P. C. (2023). Phytochemical Screening and Antioxidant Activity Analysis of N-Hexane Extract of Sonneratia alba Mangrove Leaves. Biology, Medicine, & Natural Product Chemistry, 12(2), 631-635.

Chavan, S. D., Dias, R. J., & Magdum, C. S. (2022). Allophylus cobbe Attenuates Oxidative Stress and Liver Damage in Chemically-Induced Hepatotoxicity in Wistar Rats. Tropical Journal of Natural Product Research, 6(3).

Dey, D., Quispe, C., Hossain, R., Jain, D., Ahmed Khan, R., Janmeda, P., ... & Sharifi-Rad, J. (2021). Ethnomedicinal use, phytochemistry, and pharmacology of xylocarpus granatum J. Koenig. Evidence-Based Complementary and Alternative Medicine, 2021.

Kusuma Wardani, I. G. A. A., Jawi, I. M., Senapathi, T. G. A., Sanjaya, D. A., Antari, N. P. U., Adrianta, K. A., & Suena, N. M. D. S. (2022). The Effect of Xylocarpus granatum J. Koenig Seed Extract Cream on The Number of Fibroblast and Re-Epithelialization in IIA Degree Burn Wound Healing. Indonesian Journal of Pharmacy, 33(4), 653–665.

Darmadi, J., Batubara, R. R., Himawan, S., Azizah, N. N., Audah, H. K., Arsianti, A., ... & Audah, K. A. (2021). Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug. Scientific reports, 11(1), 6080.

Das, S. K., Prusty, A., Samantaray, D., Hasan, M., Jena, S., Patra, J. K., ... & Thatoi, H. (2019). Effect of Xylocarpus granatum bark extract on amelioration of hyperglycaemia and oxidative stress associated complications in STZ-induced diabetic mice. Evidence-Based Complementary and Alternative Medicine, 2019.

Assidqi, K., Meindrawan, B., Sianipar, N. F., & Capriati, A. (2024, March). The cytotoxic activities of Xylocarpus granatum a coastal mangrove plant from East Indonesia extract against MCF-7 and HEK293 cell lines. In AIP Conference Proceedings (Vol. 3080, No. 1). AIP Publishing.

Abiola, A. A., & Adetutu, O. A. (2022). Counteract inflammatory properties of the purified ethanolic extract of Acrostichum aureum (Linn.) leaf. Journal of Applied Health Sciences and Medicine, 1(2), 43-47.

Numbere, A. O., & Maduike, E. M. (2021). Investigation of the anti-bacterial properties of mangrove fern, Acrostichum aureum in the Niger Delta, Nigeria. African Journal of Biotechnology, 20(4), 142-149.

Babuselvam, M., Abideen, S., Gunasekaran, T., Beula, J. M., & Dhinakarraj, M. (2013). Bioactivity of Avicennia marina and Rhizophora mucronata for the management of diabetes mellitus. World Journal of Pharmaceutical Research, 3(1), 11-18.

Roy, U. K., Sarkar, C., Jamaddar, S., Mondal, B., Ramproshad, S., Zulfiquar, T. N., ... & Sweilam, S. H. (2023). A detailed assessment of the traditional applications, bioactive content, pharmacology, and toxicity of Rhizophora mucronata. Journal of Herbal Medicine, 100702.

Gurudeeban, S., Kaliamurthi, S., Sheik, H. S., & Thiruganasambandam, R. (2014). Molecular docking, isolation and biological evaluation of Rhizophora mucronata flavonoids as anti-nociceptive agents. Biomedicine & Preventive Nutrition, 4(4), 555-560.

Thatoi, H., Samantaray, D., & Das, S. K. (2016). The genus Avicennia, a pioneer group of dominant mangrove plant species with potential medicinal values: a review. Frontiers in Life Science 9: 267–291.

ElDohaji, L. M., Hamoda, A. M., Hamdy, R., & Soliman, S. S. M. (2020). Avicennia marina a natural reservoir of phytopharmaceuticals: Curative power and platform of medicines. Journal of ethnopharmacology, 263, 113179.

Mahmud, I., Zilani, M. N. H., Biswas, N. N., & Bokshi, B. (2017). Bioactivities of Bruguiera gymnorrhiza and profiling of its bioactive polyphenols by HPLC-DAD. Clinical Phytoscience, 3, 1-11.

Sadeer, N. B., Sinan, K. I., Cziáky, Z., Jekő, J., Zengin, G., Jeewon, R., Abdallah, H. H., Rengasamy, K. R. R., & Mahomoodally, M. F. (2020). Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using in Vitro Studies, in Silico Docking, and Multivariate Analysis. Biomolecules, 10(5), 731.

Krishnamoorthy, M., Sasikumar, J. M., Shamna, R., Pandiarajan, C., Sofia, P., & Nagarajan, B. (2011). Antioxidant activities of bark extract from mangroves, Bruguiera cylindrica (L.) Blume and Ceriops decandra Perr. Indian journal of pharmacology, 43(5), 557-562.

Nabeelah Bibi, S., Fawzi, M. M., Gokhan, Z., Rajesh, J., Nadeem, N., RR, R. K., ... & Pandian, S. K. (2019). Ethnopharmacology, phytochemistry, and global distribution of mangroves―A comprehensive review. Marine drugs, 17(4), 231.

Haq, I., Hossain, A. S., Moneruzzaman, M., Amir, K., Merican, F., Faruq, G., ... & Azirun, M. S. (2014). Antioxidant and antibacterial activities of different extracts and fractions of a mangrove plant Sonneratia alba. International Journal of Agriculture and Biology, 16(4).

al-Mamun, M., Jahan, N., Chowdhury, M. H., Jahan, R., & Nasrin, D. (2010). Brine shrimp toxicity study of different Bangladeshi medicinal plants. Advances in Natural and Applied Sciences, 4(2), 163-173.

Yusoff, N. A., Ahmad, M., Al-Hindi, B., Widyawati, T., Yam, M. F., Mahmud, R., ... & Asmawi, M. Z. (2015). Aqueous extract of Nypa fruticans Wurmb. vinegar alleviates postprandial hyperglycemia in normoglycemic rats. Nutrients, 7(8), 7012-7026.

Nugroho, G. D., Wiraatmaja, M. F., Pramadaningtyas, P. S., Febriyanti, S., Liza, N., Naim, D. M., ... & Setyawan, A. D. (2020). Review: Phytochemical composition, medicinal uses and other utilization of Nypa fruticans. Bonorowo Wetlands 10: 51-65.

Dey, D., Quispe, C., Hossain, R., Jain, D., Ahmed Khan, R., Janmeda, P., ... & Sharifi-Rad, J. (2021). Ethnomedicinal use, phytochemistry, and pharmacology of xylocarpus granatum J. Koenig. Evidence‐Based Complementary and Alternative Medicine, 2021(1), 8922196.

Omodamiro, O., & Ikekamma, C. (2016). In vitro study of antioxidant and anticoagulant activities of ethanol extract of Pandanus tectorius leaves. International Blood Research Reviews, 5(1), 1-11.

Thomson LAJ, Englberger L, Guarino L, et al. Pandanus tectorius (Pandanus). Species Profiles for Pacific Island. Agroforestry. 2006; 1: 1-29

Ojeh, N., Subir, G., Prabhath, K., & Neuro, S. (2011). Antioxidant activity of methanol extract of Pandanus fascicularis Lam. Pharmacologyonline, 1, 833-841.

Akinwumi, K. A., Abam, E. O., Oloyede, S. T., Adeduro, M. N., Adeogun, Y. A., & Uwagboe, J. E. (2022). Acrostichium aureum Linn: traditional use, phytochemistry and biological activity. Clinical Phytoscience, 8(1), 18.

Chavan, R. B., & Gaikwad, D. K. (2013). Antibacterial Activity of Medicinally Important Two Species of Allophylus-Allophylus Cobbe (L.) Raeusch. and Allophylus Serratus (Roxb.) Kurz. Journal of Pharmacognosy and Phytochemistry, 2(1), 01-07.

Bharat, C. R., & Krishna, G. D. (2017). GC-MS analysis of young leaves of Allophylus cobbe (L.) raeusch. and Allophylus serratus (Roxb.) Kurz. Indian J. Pharm. Educ. Res, 51, 472-479.

Preeti Jain, P. J., Hossain, M. S., Kaniz Fatema, K. F., Hossain, M. A. A., Mazumder, K. U., Hemayet Hossain, H. H., ... & Reza, H. M. (2014). Anti-inflammatory, analgesic and antioxidant activities of Allophylus cobbe leaves.

Chavan, S. D., Dias, R. J., & Magdum, C. S. A Review on Medicinal Importance of Allophylus cobbe (L.) Raeusch and Garuga pinnata Roxburgh.

Liang, X., Niu, P., Li, J., Guan, X., Zhang, Y., & Li, J. (2023). Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand. Molecules, 28(4), 1658.

Mahmud, I., Islam, M. K., Saha, S., Barman, A. K., Rahman, M. M., Anisuzzman, M., ... & Rahmatullah, M. (2014). Pharmacological and ethnomedicinal overview of Heritiera fomes: future prospects. International Scholarly Research Notices, 2014.

Chitra, A., Santhanakrishnan, K., & Senthil Kumar, N. (2024). Overview Of A Multipotent Medicinal Tree Heritiera Littoralis: For Future Prospects.

Yang, Y., Zhang, Y., Liu, D., Li-Weber, M., Shao, B., & Lin, W. (2015). Dolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor activities. Fitoterapia, 103, 277-282.

Armania, N., Yazan, L. S., Musa, S. N., Ismail, I. S., Foo, J. B., Chan, K. W., ... & Ismail, M. (2013). Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest. Journal of Ethnopharmacology, 146(2), 525-535.

Abubakar, S., Al-Mansoub, M. A., Murugaiyah, V., & Chan, K. L. (2019). The phytochemical and anti-inflammatory studies of Dillenia suffruticosa leaves. Phytotherapy research: PTR, 33(3), 660–675.

Muharini, R., Lestari, I., & Masriani, M. (2021). Antioxidant-phenolic content correlation of phenolics rich fractions from Dillenia suffruticosa wood bark. Pharmaciana, 11(2), 283-292.

Fitriansyah, S. N., Fidrianny, I., & Hartati, R. (2021). Pharmacological activities and phytochemical compounds: Overview of Pouteria genus. Pharmacognosy Journal, 13(2).

Handayani, Sri. (2018). Identifikasi Jenis Tanaman Mangrove Sebagai Bahan Pangan Alternatif di Kabupaten Sidoarjo Jawa Timur. Jurnal Teknologi Pangan. 12 (2).

Purnobasuki, H. (2019). Potensi Mangrove Sebagai Tanaman Obat (Short Communication). Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati, 9(2).

Rupidara, A.D.N., Tisera, W.L., Ledo, M.E.S. (2020). Studi Etnobotani Tumbuhan Mangrove di Kupang. Jurnal Ilmu dan Teknologi Kelautan Tropis, 12(3): 875-884.

Purwanti, R. (2016). Studi Etnobotani Pemanfaatan Jenis-Jenis Mangrove Sebagai Tumbuhan Obat di Sulawesi. Proceeding of Mulawarman Pharmaceuticals Conferences, 3(2), 340–348.

Prakashamani, G., Srivani, A., & Mohan, G. K. (2019). A Review on Avicennia Officinalis. International Journal of Pharmacy and Biological Sciences-IJPBS TM, 9(1), 553-557.

Dotulong, V., Wonggo, D., Montolalu, L. A. D. Y. (2018). Phytochemical Content, Total Phenols, and Antioxidant Activity of Mangrove Sonneratia alba Young Leaf Through Different Extraction Methods and Solvents. International Journal of ChemTech Research. Vol. 11 No. 11, pp 356-363.

Wonggo, D., Berhimpon, S., Kurnia, D., & Dotulong, V. (2017). Antioxidant activities of mangrove fruit (Sonneratia alba) taken from Wori Village, North Sulawesi. Indonesia Int. J. ChemTech Res, 10, 284-90.

Musara, C., Aladejana, E. B., & Mudyiwa, S. M. (2020). Review of botany, nutritional, medicinal, pharmacological properties and phytochemical constituents of bruguiera gymnorhiza (L.) Lam, (Rhizophoraceae). Journal of Pharmacy and Nutrition Sciences, 10(4), 123-132.

Syawal, H., Hakim, L., & Effendi, I. (2020). Phytochemical analysis of Rhizophora apiculata leaf extract and its inhibitory action against Staphylococcus aureus, Aeromonas hydrophila and Pseudomonas aeruginosa. Aquaculture, Aquarium, Conservation & Legislation, 13(4), 2242-2249.

Vittaya, L., Charoendat, U., Janyong, S., Ui-Eng, J., & Leesakul, N. (2022). Comparative analyses of saponin, phenolic, and flavonoid contents in various parts of Rhizophora mucronata and Rhizophora apiculata and their growth inhibition of aquatic pathogenic bacteria. Journal of Applied Pharmaceutical Science, 12(11), 111-121.

Rahmania, Nadya & Herpandi, Herpandi & Rozirwan, Rozirwan. (2018). Phytochemical Test of Mangrove Avicennia alba, Rhizopora apiculata and Sonneratia alba from Musi River Estuary, South Sumatera. BIOVALENTIA: Biological Research Journal. 4. 10.24233/BIOV.4.2.2018.116.

Vasanthakumar, K., Dineshkumar, G., & Jayaseelan, K. (2019). Phytochemical screening, GC-MS analysis and antibacterial evaluation of ethanolic leaves extract of Avicennia marina. Journal of Drug Delivery and Therapeutics, 9(4-A), 145-150.

Khattab, R., Gaballa, A., Zakaria, S., Ali, A. A., Sallam, I., & Temraz, T. (2012). Phytochemical analysis of Avicennia marina and Rhizophora mucronata by GC-MS. Catrina: The International Journal of Environmental Sciences, 7(1), 115-120.

Takarina, N. D., Arif, G. A. F., & Juhriah, S. A. (2018, October). Phytochemical contents and antioxidant activities of mangrove (Avicennia marina) leaves extract. In AIP Conference Proceedings (Vol. 2023, No. 1). AIP Publishing.

Ganesh, S., & Vennila, J. J. (2011). Phytochemical analysis of Acanthus ilicifolius and Avicennia officinalis by GC-MS. Research Journal of Phytochemistry, 5(1), 60-65.

Vittaya, L., Charoendat, U., Janyong, S., & Leesakul, N. (2020). Phytochemical screening of Bruguiera cylindrica extracts and pathogenic antibacterial activities. Rajamangala University of Technology Srivijaya Research Journal, 12(2).

Islam, S., Millat, M. S., Hussain, M. S., Rahman, M. A., Moghal, M. M. R., Nipa, J. A., ... & Hossain, M. (2017). Elucidation of in-vitro thrombolytic, membrane stabilizing, cytotoxic activities and phytochemical nature of Bruguiera cylindrica leaves. Biology, Engineering, Medicine and Science Reports, 3(1).

Baba, S., Chan, H. T., Kainuma, M., Kezuka, M., Chan, E. W., & Tangah, J. (2016). Botany, uses, chemistry and bioactivities of mangrove plants III: Xylocarpus granatum. ISME/GLOMIS Electronic Journal, 14(1), 1-4.

Jadhav, B. L., Mukhtar, Q. F., & Pagare, B. G. (2013). Evaluation of antioxidant properties and phytochemical analysis in the stem and leaves of Ceriops tagal mangroves. Res J Biotechnol, 8(9), 28-31.

Basco, M. V., Mallare, J. A. M. R., Ruiz, S. L. A., Jacob, J. K. S., & Divina, C. C. (2016). Evaluation of the phytochemical, antioxidant and cytotoxic properties of tungog (Ceriops tagal), a Philippine mangrove species.

Shah, M. D., Seelan, J. S. S., & Iqbal, M. (2020). Phytochemical investigation and antioxidant activities of methanol extract, methanol fractions and essential oil of Dillenia suffruticosa leaves. Arabian Journal of Chemistry, 13(9), 7170-7182.

Hassanpour, S. H., & Doroudi, A. (2023). Review of the antioxidant potential of flavonoids as a subgroup of polyphenols and partial substitute for synthetic antioxidants. Avicenna journal of phytomedicine, 13(4), 354–376. https://doi.org/10.22038/AJP.2023.21774

Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A. H., & Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules (Basel, Switzerland), 25(22), 5243. https://doi.org/10.3390/molecules25225243

Mieres-Castro, D., & Mora-Poblete, F. (2023). Saponins: research progress and their potential role in the post-COVID-19 pandemic era. Pharmaceutics, 15(2), 348.

Rahman, M. M., Rahaman, M. S., Islam, M. R., Rahman, F., Mithi, F. M., Alqahtani, T., Almikhlafi, M. A., Alghamdi, S. Q., Alruwaili, A. S., Hossain, M. S., Ahmed, M., Das, R., Emran, T. B., & Uddin, M. S. (2021). Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects. Molecules (Basel, Switzerland), 27(1), 233. https://doi.org/10.3390/molecules27010233

Tong, Z., He, W., Fan, X., & Guo, A. (2022). Biological function of plant tannin and its application in animal health. Frontiers in veterinary science, 8, 803657.

Aryal, B., Raut, B. K., Bhattarai, S., Bhandari, S., Tandan, P., Gyawali, K., ... & Parajuli, N. (2022). Potential Therapeutic Applications of Plant‐Derived Alkaloids against Inflammatory and Neurodegenerative Diseases. Evidence‐Based Complementary and Alternative Medicine, 2022(1), 7299778.

Olofinsan, K., Abrahamse, H., & George, B. P. (2023). Therapeutic role of alkaloids and alkaloid derivatives in cancer management. Molecules, 28(14), 5578.

DOI: https://doi.org/10.24198/ijpst.v6i1.55879