In Silico Study of Flavonoid from Caesalpinia sappan L. against HMG-CoA Reductase as Antihypercholesterolemia

Aditya Luhung; Kinar Shefelin; Nurqisthi Iqlima Adiputri; Alifa Nisa Deliyana; Michelle Natasha Colin; Nur Shelly Ester Claudina; Rina Fajri Nuwarda

doi:10.24198/ijpst.v6i3.56077

In Silico Study of Flavonoid from Caesalpinia sappan L. against HMG-CoA Reductase as Antihypercholesterolemia

Aditya Luhung, Kinar Shefelin, Nurqisthi Iqlima Adiputri, Alifa Nisa Deliyana, Michelle Natasha Colin, Nur Shelly Ester Claudina, Rina Fajri Nuwarda

Abstrak

Hypercholesterolemia is a severe condition characterized by elevated blood cholesterol levels exceeding 240 mg/dL, contributing to over 18.5 million deaths since 2019. Simvastatin, a widely used cholesterol-lowering therapy, inhibits the enzyme HMG-CoA reductase. However, despite its efficacy, statin-based drugs can cause adverse effects such as hepatotoxicity, malaise, rhabdomyolysis, and myopathy. Sappan wood (Caesalpinia sappan L.) is a potential alternative known for its antihypercholesterolemic properties, attributed to its main compounds: sappanone B, brazilin, and hematoxylin. This study aimed to evaluate the potential of flavonoids in sappan wood as HMG-CoA reductase inhibitors using molecular docking analysis. The results revealed that sappanone B exhibited the lowest binding energy (-7.71 kcal/mol) and an inhibition constant of 2.22 μM, followed by brazilin (-7.34 kcal/mol, 4.17 μM) and hematoxylin (-7.00 kcal/mol, 7.45 μM). These findings suggest that sappanone B, brazilin, and hematoxylin possess significant potential as competitive HMG-CoA reductase inhibitors, providing a promising natural alternative for hypercholesterolemia treatment with potentially fewer side effects.

Kata Kunci

Antihypercholesterolemia; Caesalpinia sappan L.; HMG-CoA Reductase; Sappan Wood

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/ijpst.v6i3.56077