Formulasi dan Evaluasi Sediaan Mikrohidrogel dengan Kandungan Piperin sebagai Anti Jerawat
Abstrak
Jerawat adalah kondisi peradangan kulit yang ditandai dengan pembentukan papula, komedo, pustula, jaringan parut, dan nodul. Meskipun perawatan jerawat secara konvensional telah tersedia yaitu dengan antibiotik, tetapi penggunaannya memiliki efek samping dan dalam penggunaan jangka Panjang menyebabkan resistensi antibiotik. Penelitian ini bertujuan untuk memformulasikan dan mengevaluasi mikro hidrogel topikal yang mengandung piperin sebagai obat anti jerawat yang potensial. Tiga formulasi yang mengandung piperin dengan variasi konsentrasi 10% (F1A), 20% (F1B), dan 30% (F1C) dibuat dengan menggunakan kitosan dan NaTPP sebagai basis mikrohidrogel. Konsentrasi hambat minimum (KHM) piperin terhadap Propionibacterium acne diuji dengan metode dilusi padat. Karakterisasi terhadap sifat fisikokimia mikrohidrogel dilakukan terhadap parameter organoleptic, homogenitas, daya sebar, pH, dan viskositas, pH. Uji stabilitas terhadap formula dilakukan selama 28 hari. Dari ketiga formula, F1A menunjukkan aktivitas yang sedang terhadap Propionibacterium acne (diameter hambat 10.26 ± 0.57 mm) dan memenuhi persyaratan mutu untuk sediaan mikrohidrogel.
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DOI: https://doi.org/10.24198/ijpst.v12i0.57781
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