Formulasi dan Evaluasi Sediaan Mikrohidrogel dengan Kandungan Piperin sebagai Anti Jerawat

Retty Handayani, Nurul Auliasari, Clarissa F. Khaerunnisa, Adith P. Kusumawardhana, Raden Maya Febriyanti

Abstrak


Jerawat adalah kondisi peradangan kulit yang ditandai dengan pembentukan papula, komedo, pustula, jaringan parut, dan nodul. Meskipun perawatan jerawat secara konvensional telah tersedia yaitu dengan antibiotik, tetapi penggunaannya memiliki efek samping dan dalam penggunaan jangka Panjang menyebabkan resistensi antibiotik. Penelitian ini bertujuan untuk memformulasikan dan mengevaluasi mikro hidrogel topikal yang mengandung piperin sebagai obat anti jerawat yang potensial. Tiga formulasi yang mengandung piperin dengan variasi konsentrasi 10% (F1A), 20% (F1B), dan 30% (F1C) dibuat dengan menggunakan kitosan dan NaTPP sebagai basis mikrohidrogel. Konsentrasi hambat minimum (KHM) piperin terhadap Propionibacterium acne diuji dengan metode dilusi padat. Karakterisasi terhadap sifat fisikokimia mikrohidrogel dilakukan terhadap parameter organoleptic, homogenitas, daya sebar, pH, dan viskositas, pH. Uji stabilitas terhadap formula dilakukan selama 28 hari. Dari ketiga formula, F1A menunjukkan aktivitas yang sedang terhadap Propionibacterium acne (diameter hambat 10.26 ± 0.57 mm) dan memenuhi persyaratan mutu untuk sediaan mikrohidrogel.


Kata Kunci


Anti jerawat; Mikrohidrogel; Piperin; Propionibacterium acne

Teks Lengkap:

PDF

Referensi


Borse RR, Premchandani LA, Dhankani AR, Pawar SP. Formulation and Evaluation of Herbal Anti-Acne Gel Containing Neem and Garlic Extract. IJPPR. 2020;17(2):84-94. www.ijppr.humanjournals.com

Dragicevic N, Maibach HI. Liposomes and Other Nanocarriers for the Treatment of Acne Vulgaris: Improved Therapeutic Efficacy and Skin Tolerability. Pharmaceutics. 2024;16(3). doi:10.3390/ pharmaceutics16030309

Olutunmbi Y, Paley K, English JC. Adolescent Female Acne: Etiology and Management. J Pediatr Adolesc Gynecol. 2008;21(4):171-176. doi:10.1016/j. jpag.2007.07.004

Brown TL, Petrovski S, Dyson ZA, Seviour R, Tucci

J. The formulation of bacteriophage in a semi solid preparation for control of propionibacterium acnes growth. PLoS One. 2016;11(3). doi:10.1371/journal. pone.0151184

Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-973.e33. doi:10.1016/j. jaad.2015.12.037

Fitriani L, Afifah, Ismed F, Bakhtiar A. Hydrogel formulation of usnic acid and antibacterial activity test against propionibacterium acne. Sci Pharm. 2019;87(1). doi:10.3390/scipharm87010001

Ansong JA, Asante E, Johnson R, et al. Formulation and Evaluation of Herbal-Based Antiacne Gel Preparations. Biomed Res Int. 2023;2023. doi:10.1155/2023/7838299

Hin KF, Yusof YA, Salim N, Mohd Amin NAA. Formulation and characterization of polyherbal anti-acne gel containing Citrus aurantifolia and Aloe barbadensis extracts for the management of acne vulgaris. Food Res. 2023;6(Supplementary 3):45-53. doi:10.26656/ fr.2017.6(s3).4

Nawarathne NW, Wijesekera K, Wijayaratne GB, Napagoda M. Development of novel topical cosmeceutical formulations with antimicrobial activity against acne-causing microorganisms from Coriandrum sativum L. J Sci. 2023;14(1):1-

doi:10.4038/jsc.v14i1.60

http://jurnal.unpad.ac.id/ijpst/

Indonesian Journal of Pharmaceutical Science and Technology

Wahyuningsih ES, Sumaryono W, Chaidir C. Combination Gel Formulation Extracts of Moringa Leaf and Red Betel Leaf as an Inhibitor of Acne-Causing Bacteria (Propionibacterium acne and Staphylococcus aureus). Jurnal Fitofarmaka Indonesia. 2021;8(3):18-

Vol. 12 Suppl. 2 (2025):112-118

J Pharm Sci Res. 2018;9(10):4089. doi:10.13040/ IJPSR.0975-8232.9(10).4089-01

doi:10.33096/jffi.v8i3.727

Stojanović-Radić Z, Pejčić M, Dimitrijević M, et al. Piperine-A Major Principle of Black Pepper: A review of its bioactivity and studies. Applied Sciences (Switzerland). 2019;9(20). doi:10.3390/app9204270

Eka Ermawati D, Ramadhani CI. Formulation of AntiAcne Gel of Moringa Oleifera L Ethanolic Extract and Antibacterial Test on Staphylococcus Epidermidis. Vol 2019. www.journal.ugm.ac.id/v3/JFPS

Azrifitria A, Purwaningsih S, Fatmala AR. In vitro antimicrobial activity and formulation of herbal anti-acne gel containing Rhizophora stylosa fruits extract. Pharmaciana. 2022;12(3):309. doi:10.12928/ pharmaciana.v12i3.21942

Gorgani L, Mohammadi M, Najafpour GD, Nikzad

M. Piperine—The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations. Compr Rev Food Sci Food Saf. 2017;16(1):124-140. doi:10.1111/1541-4337.12246

Gopalakrishna PK, Jayaramu RA, Boregowda SS, et al. Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis. Gels. 2023;9(7). doi:10.3390/ gels9070577

Alshehri S, Bukhari SI, Imam SS, et al. Formulation of Piperine-Loaded Nanoemulsion: In Vitro Characterization, Ex Vivo Evaluation, and Cell Viability Assessment. ACS Omega. 2023;8(25):22406-22413. doi:10.1021/acsomega.2c08187

Raj Joshi D, Chandra Shrestha A, Adhikari N. A REVIEW ON DIVERSIFIED USE OF THE KING OF SPICES: PIPER NIGRUM (BLACK PEPPER). Int

Bilal M, Lubis MS, Yuniarti R, Nasution HM. Formulation Of Anti-Acne Extract Aloe Vera (Aloe Vera (L.) Burm.f.) In Hibiting The Activity Of Propionibacterium Acnes. International Journal of Health and Pharmaceutical. 2023. 3(2), 241–248. https://doi.org/10.51601/ijhp. v3i1.140

Kusuma SAF, Abdassah M, Valas BE. Formulation and evaluation of anti acne gel containing citrus aurantifolia fruit juice using carbopol as gelling agent. International Journal of Applied Pharmaceutics. 2018;10(4):147-152. doi:10.22159/ijap.2018v10i4.26788

Rathore C, Gupta N, Kapoor V, Sharma N, Rajput DS. FORMULATION, DEVELOPMENT AND EVALUATION OF POLYHERBAL GEL FOR EFFECTIVE TREATMENT OF ACNE. Asian Journal of Pharmaceutical Education and Research. 2021;10(2):8-18. doi:10.38164/ ajper/10.2.2021.8-18

Chen MX, Alexander KS, Baki G. Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application. J Pharm (Cairo). 2016;2016:1-10. doi:10.1155/2016/5754349

Kola-Mustapha AT, Yohanna KA, Ghazali YO, Ayotunde HT. Design, formulation and evaluation of Chasmanthera dependens Hochst and Chenopodium ambrosioides Linn based gel for its analgesic and anti-inflammatory activities. Heliyon. 2020;6(9). doi:10.1016/j.heliyon.2020.e04894




DOI: https://doi.org/10.24198/ijpst.v12i0.57781

Refbacks

  • Saat ini tidak ada refbacks.


 Switch to English

Back to Top

View My Stats

Penerbit Universitas Padjadjaran

Jurnal ini terindeks di :

      

Creative Commons Attribution :

Creative Commons License
Indonesian Journal of Pharmaceutical Science and Technology by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Based on a work at http://jurnal.unpad.ac.id/ijpst/