Formulation Sunscreen Spray Gel of Vetiveria zizanioides (L.) Nash Root Infusion

Vella Lailli Damarwati; Rizky Anita Fajarani; Meilidya Vani Sabeta; Muhammad Fariez Kurniawan; Aji Winanta

doi:10.24198/ijpst.v12s1.59024

Formulation Sunscreen Spray Gel of Vetiveria zizanioides (L.) Nash Root Infusion

Vella Lailli Damarwati, Rizky Anita Fajarani, Meilidya Vani Sabeta, Muhammad Fariez Kurniawan, Aji Winanta

Abstrak

Vetiveria zizanioides (L.) Nash is one of the plants with high flavonoid compound content with antioxidant activity. This study aims to formulate a spray gel of the root of Vetiveria zizanioides (L.) Nash infusion determines UV protection and observes the level of irritation caused by the application. This study used formulas at variations concentrations FI 1%, FII 5%, and FIII 10%. The formulas observed flavonoid content, sun protection factor (SPF) value, and irritation index. Flavonoid content was tested using the Willstatter method. The SPF value was determined in vitro using UV-spectrophotometer, while the irritation test was conducted using the Draize test method. The SPF value test results showed that Formula 0 (F0), FI, FII, FIII, and the commercial preparation had SPF values of 0.355, 2.856, 5.324, 6.634, and 13.438, respectively. Meanwhile, the irritation test obtained an irritation infection of 0.3 in the commercial preparation and 0.6 in F3. Therefore, FII has the potential to be UV-protected and have a minimal irritating effect.

Kata Kunci

Spray; Sun Protecting Factor; Sunscreen; Vetiveria zizanioides (L.) Nash

Teks Lengkap:

PDF

Referensi

Fuhlbrigge RC, Chaiban R. The Immune System, The Skin, And Childhood Rheumatic Disease. Current Rheumatol Reports. 2011;13(2):103–9.

Fonseca M, Rehman M, Soares R, Fonte P. The Impact of Flavonoid-Loaded Nanoparticles in The UV Protection and Safety Profile of Topical Sunscreens. Biomolecules. 2023;13(3):2-32.

Jesus A, Mota S, Torres A, Cruz Mt, Sousa E, Almeida If, Cidade H. Antioxidants in Sunscreens: Which and What For. Antioxidants. 2023;12(1):138.

Wahid Rah. Pengaruh Polivinilpirolidon Sebagai Polimer Mukoadhesif Terhadap Sifat Fisik Patch Ekstrak Kulit Buah Delima (Punica granatum L.). Lumbung Farmasi: Jurnal Ilmu Kefarmasian. 2020;1(2):85-89.

Oliveira FGS, Veras BOS, Silva APS, Araújo AD, Barbosa DCS, Silva TC M, … Almeida JRGS. Photoprotective activity and HPLC-MS-ESI-IT profile of flavonoids from the barks of Hymenaea martiana Hayne (Fabaceae): development of topical formulations containing the hydroalcoholic extract. Biotechnology & Biotechnological Equipment. 2021; 35(1): 504–16.

Ghazi S. Do The Polyphenolic Compounds from Natural Products Can Protect the Skin from Ultraviolet Rays? Results Chemistry. 2022;4: 1-9.

Agati G, Brunetti C, Ferdinando M, Ferrini F, Pollastri S, and Tattini M. Functional Roles of Flavonoids in Photoprotection: New Evidence, Lessons from The Past. Plant Physiology Biochemistry. 2013;72: 35–45.

Gupta G and Rishishwar P. Antioxidant Activity and Trace Elements Profile of Leaf Extract of Vetiveria zizanioides. Journal Of Pharmaceutical Sciences and Research.2017;9(8):1255-9.

Indalifiany A, Zubaydah WS, Kasim ER. Formulasi Spray Gel Ekstrak Etanol Batang Etlingera rubroloba Menggunakan HPMC Sebagai Gelling Agent. Jurnal Sains dan Kesehatan. 2023;5(2):140–8.

Octaviani M, Fadhli H, Yuneistya E, Tinggi S, Riau IF, and Kunci K. Uji Aktivitas Antimikroba Ekstrak Etanol dari Kulit Bawang Merah (Allium cepa L.) dengan Metode Difusi Cakram. Pharmaceutical Sciences and Research. 2019;6(1):62–8.

Malsawmtluangi C, Nath DK, Jamatia I, Lianhimgthangi EZ, and Pachuau L. Determination of Sun Protection Factor (SPF) Number of Some Aqueous Herbal Extracts. Journal of Applied Pharmaceutical Sciences. 2013;3(9):150–1.

OeECD. Acute Dermal Irritation/Corrosion. OECD Guidelines for the Testing of Chemicals, Section 4 Health Effects. 2015; 404:1–8.

Handayani S, Kurniawati I, Abdul Rasyid F. Uji Aktivitas Antioksidan Ekstrak Daun Karet Kebo (Ficus elastica) dengan Metode Peredaman Radikal Bebas DPPH (1,1-Diphenyl-2-Picrylhydrazil). Jurnal Farmasi Galenika. 2020;6(1):141–50.

Ergina, Nuryanti S, and Pursitasari ID. Uji Kualitatif Senyawa Metabolit Sekunder pada Daun Palado (Agave angustifolia) yang Diekstraksi dengan Pelarut Air dan Etanol. Jurnal Akademika Kimia. 2014;3(3):165–72.

Shah H, Jain A, Laghate G, and Prabhudesai D. Pharmaceutical Excipients. Remington: The Science and Practice of Pharmacy. 2020;633–43.

BPOM Republic of Indonesia. Food and Drug Supervisory Agency Regulation Number 10 of 2022 Concerning Guidelines For In Vivo Preclinical Toxicity Testing. Republic Of Indonesia Food and Drug Supervisory Agency. 2022;1–220.

Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG …. Jaremko M. Important Flavonoids and Their Role as a Therapeutic Agent. Molecules. 2020;25(22):5243.

Mazidi M, Katsiki N, and Banach M. A Higher Flavonoid Intake is Associated with Less Likelihood of Nonalcoholic Fatty Liver Disease: Results from a Multiethnic Study. Journal of Nutritional Biochemistry. 2019;65: 66–71.

Ikalinus R, Widyastuti SK, and Setiasih NLE. Skrining Fitokimia Ekstrak Etanol Kulit Batang Kelor (Moringa oleifera). Indonesia Medicus Veterinus. 2015;4(1): 71–9.

Devprakash, Sreenivasan K, Subburaju T. Comparative Antioxidant Studies of Ethanol Extract and Fresh Aqueous Extract of Vetiveria zizanioides. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(5): 325–31.

Anindhita MA, and Oktaviani N. Formulasi Spray Gel Ekstrak Daun Pandan Wangi Sebagai Antiseptik Tangan. Parapemikir: Jurnal Ilmiah Farmasi. 2020;9(1):14.

Rusdiaman and Dewi ST. Efektivitas Infusa Daun Sawo (Manilkara zapota L.) terhadap Pertumbuhan Salmonella Thypi. Media Farmasi Poltekkes Makassar. 2019;15(1):71–6.

Andini T, Yusriadi Y and Yuliet Y. Optimasi Pembentuk Film Polivinil Alkohol dan Humektan Propilen Glikol pada Formula Masker Gel Peel Off Sari Buah Labu Kuning (Cucurbita moschata Duchesne) sebagai Antioksidan. Jurnal Farmasi Galenika. 2017;3(2):165–73.

Natalia L, Jaya EH, and Melindah RE. Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12,5% sebagai Tabir Surya. Jurnal MIPA. 2020;1(2):42–6.

Nasution MR, Sari AP, Utami IP, Halianti T. Penentuan Aktivitas Tabir Surya Ekstrak Etanol Daun Marpuyan (Rhodamnia cinerea Jack.) Secara In Vitro. Jurnal Dunia Farmasi. 2020;4(2):59-67.

Maheswari U, Sridevi Sangeetha KS, Umamaheswari S, Uma C, Reddy M, Kalkura SN. Flavonoids: Therapeutic Potential of Natural Pharmacological Agents In vitro Antioxidant Activity. International Journal Pharmacy Sciences and Research. 2016;7(10):3924.

Rajasekar M, Mary J, Sivakumar M, Selvam M. Recent Developments In Sunscreens Based on Chromophore Compounds and Nanoparticles. Royal Society of Chemistry. 2024;14(4):2529–63.

Fatmawaty A, Manggau MA, Tayeb R, Al-Adawiah R. Uji Iritasi Krim Hasil Fermentasi Bunga Rosella (Hibiscus sabdariffa L.) dengan Variasi Konsentrasi Emulgator Novemer pada Kulit Kelinci (Oryctalagus cuniculus). Journal pf Pharmaceutical and Medicinal Sciences. 2016;1(2):62–5.

DOI: https://doi.org/10.24198/ijpst.v12s1.59024