The Effect of Gmelina arborea and Falcataria moluccana Waste Extracts on Glucose Levels and Histology of Alloxan-Induced Hyperglycemic Mice Model

Alfi Rumidatul

doi:10.24198/ijpst.v12i3.61846

The Effect of Gmelina arborea and Falcataria moluccana Waste Extracts on Glucose Levels and Histology of Alloxan-Induced Hyperglycemic Mice Model

Alfi Rumidatul

Abstrak

White teak (Gmelina arborea) and Sengon (Falcataria moluccana) have been shown to reduce blood sugar levels because they contain flavonoid chemicals that can be employed as antioxidants. The goal of this study is to see how Gmelina arborea and Falcataria moluccana extracts treated with polar and non-polar solvents restore blood sugar, pancreatic, and liver damage in mice. The extract was prepared using the maseration method and tested for its efficacy in decreasing blood sugar and improving pancreatic and liver function by measuring glucose levels in whole blood and histology tissues. The data were collected and then analyzed using SPSS statistical testing software (Statistical Product Service Solution). Glucose levels were measured before and after treatment, and the pancreas and liver were stained with hematoxylin-eosin. The study found that administering G. arborea and F. moluccana extracts led in significant changes in the lowering of blood glucose levels in mice, as well as improvements in the histology of the liver and pancreatic organs. However, the polar solvent (methanol) produced more substantial outcomes in lowering blood glucose levels, although the non-polar solvent (n-hexane) improved the histology of both organs. According to the findings, G. arborea and F. moluccana extracts in both polar (methanol) and non-polar (n-hexane) solvents improve the liver histology of hyperglycemic mice.

Kata Kunci

Anti-diabetic; Blood Glucose; Histology

Teks Lengkap:

PDF (English)

Referensi

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DOI: https://doi.org/10.24198/ijpst.v12i3.61846