Adverse Drug Reactions in Hospitalized-Geriatric Patients with Hypertension

Andi I. Julianti, Lia Amalia, Sri Hartini

Abstract


Adverse drug reactions (ADRs) occur often in geriatric patients due to various factors which include a decrease in the physiological function and organs, nutritional deficiencies, multipathology, and polypharmacy. This study aimed to identify and analyse ADRs of hospitalized-geriatric patients with hypertension. We conducted a cross-sectional retrospective study (August 2012 to January 2013). Probability determination was calculated by the Naranjo scale. The subjects on this study were hospitalized-geriatric patients (n=86, 46.51% male, and 53.48% female). Thirty-one patients (11 men and 20 women) participated in this study by completing questionnaires to calculate ADRs probability using the Naranjo scale. The probability results were 7 probable, 8 possible, and 16 doubtful. Moreover, we observed that there were drug-related problems (DRP) during therapy, e.g., appropriate dose (59.37%), and inappropriate dose 34.37%. It can be concluded that in hospitalized-geriatric patients with hypertension, some problems related to ADRs remain existed.

Keywords


Geriatric, hypertension, adverse drug reactions

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References


World Health Organization (WHO). WHO Draft Guidelines for Adverse Event Reporting and Learning Systems. Geneva: WHO, 2005.

Schatz SN, Weber RJ. Adverse Drug Reactions (Adverse Drug Effects). Pharmacother Self-Assessment Program. 2015;42(1):12-16.

Beijer HJM, De Blaey CJ. Hospitalisations caused by adverse drug reactions (ADRs): A meta-analysis of observational studies. Pharmacy World and Science. 2002;24(2):46-54.

Pirmohamed M, James S, Meakin S, Green C. Adverse drug reactions as cause of admission to hospital: Authors’ reply. Bmj. 2004;329(7463):460.

Kongkaew C, Noyce PR, Aschcroft DM. Annals of Pharmacotherapy Objective, Findings, Discussion , Conclusions. Annalysis of Pharmacotherapy. 2008;42(7):1017-1025.

Lavan AH, Gallagher P. Predicting risk of adverse drug reactions in older adults. Theapeutic Advance in Drug Safety. 2016;7(1):11-22.

Brooks JO, Hoblyn JC. Secundary mania in older adults. American Journal of Psychiatry. 2005;162:2033-8.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Journal of American Medical Association. 2003;289:2560-2572.

Nawi R, Arsunan A, Jalla K. Analisis Faktor Risiko Kejadian Hipertensi pada Dewasa Muda di Unit Rawat Jalan Rumah Sakit Umum Labuang Baji Makasar. Jurnal Media Kesehatan Masyarakat Indonesia. 2006.

Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. Journal of American Medical Association. 1996;275:1557-1562.

Danan G, Benichou C. Causality assessment of adverse reactions to drugs – I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. Journal of Clinical Epidemiology. 1993;46:1323-1330.

Maria V and Victorino, R. Development and validation of a clinical scale for the diagnosis of druginduced hepatitis. Hepatology. 1997;26:664-669.

World Health Organization. The use of the WHO-UMC system for standardized case causality assessment. World Health Organization, Uppsala Monitoring Centre. 2015.

Naranjo C, Busto U, Sellers E, Sandor P, Ruiz I, Roberts E. A method for estimating the probability of adverse drug reactions. Clinical Pharmacology Therapy. 1981;30:239-245.




DOI: https://doi.org/10.15416/pcpr.v4i3.24923

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