Effectiveness of Highly Active Anti-retroviral Therapy (HAART) in the Adult Population in the Ashanti Region of Ghana
Abstract
AIDS is the late stage of infection with the Human Immunodeficiency Virus (HIV). Even though the Highly Active Antiretroviral Therapy (HAART) for the management of HIV/ AIDS has been in existence in Ghana since 2003, there is still limited data on their effectiveness. This study therefore sort to ascertain the effectiveness of HAART used at Anti-retroviral therapy (ART) Centres in the Ashanti region of Ghana by assessing its effects on immunological and haematological markers as well as some significant indicators such as body temperature and blood pressure changes. The study was a retrospective cross sectional study which reviewed medical record folders of 156 HIV infected patients who had attended the selected ART centres in the Ashanti region of Ghana between 2010 and 2014. About 49% of the study population had a significant rise in their CD4 counts after six months strict adherence to specific HAART regimen. HAART effectively reduced viral loads and increased CD4 counts in most of the patients whose medical record folders were reviewed. Socioeconomic factors, formal education and lack of health literacy had a significant effect on adherence to the HAART regimen, however; marital status of patients did not have any significant effect on adherence, CD4 counts and the haemoglobin concentration of patients. Based on results obtained from this study, HAART could be considered as effective in the adult population in the Ashanti region of Ghana provided there is a high level of adherence. Immunological and haematological markers for the assessment of effectiveness could also improve with high adherence recommended HAART regimen
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World Health Organization Policy on treatment and management of HIV (2015). Available at http://www.who. int/hiv/pub/guidelines/en/, (Assessed on May, 2017)
Owiredu WKB, Quaye L, Amidu N, Addai-Mensah O. Prevalence of anaemia and immunological markers among Ghanaian HAART-naïve HIV-patients and those on HAART. African Health Sciences. 2011; 11(1): 2-15
Ghana AIDS Commission (2016) HIV Sentinel Survey report for 2016. Available at http://www.ghanaids.gov.gh/gac1/ aids_info.php (Assessed on May, 2017)
Ghana AIDS Commission (2014) 2014 Status report, Available at http://www. ghanaids.gov.gh/gac1/pubs/2014%20 STATUS%20REPORT.pdf, (Assessed on May, 2017)
Annison L, Dompreh A. Adu-Sarkodie
Y. The immunological response of HIV- positive patients initiating HAART at the Komfo Anokye Teaching hospital, Kumasi, Ghana. Ghana Medical Journal 2013; 47 (4):164-70.
Fox, M.P. and Rosen, S. A new cascade of HIV care for the era of “treat all”. PLoS Medicine. 2017 14(4): e1002268
Yamen T. Statistics, An introductory Analysis. 2nd ed, New York: Harper and Row, 1967
Amornkul PN, Vandenhoudt H, Nasokho P, Odhiambo F, Mwaengo D, Hightower A, et al. HIV prevalence and associated risk factors among individuals aged 13- 34 years in rural western Kenya. PloS One 2009; 4 (7):6470.
Glynn JR, Caraël M, Auvert B, Kahindo M, Chege J, Musonda R el al. Why do young women have a much higher prevalence of HIV than young men: A study in Kisumu, Kenya and Ndola, Zambia. AIDS 2001; 15 (4 suppl):S51-60
UNAIDS (2002). Prevalent rates of HIV/AIDS among age groups in 2002. Available at http://www. who.int/hiv/topics/mtct/meetings/ NairobiFeb07Operationalguide.pdf, (Assessed on May, 2017)
de Walque D. Discordant couples: HIV infection among couples in Burkina Faso, Cameroon, Ghana, Kenya, and Tanzania. World Bank Policy Research Working Paper No. 3956; 2006.
Kalichman SC, Ramachandran B, Catz S. Adherence to combination of antiretrovirals in HIV patients of low health literacy. Journal of General Internal Medicine 1999; 14(5): 267-273.
UNESCO (2015). HIV/AIDS and Education. Available at http://unesdoc.unesco.or g/ images/0012/001286/128657e.pdf, (Assessed on May, 2017)
Kelly MJ. The encounter between HIV/ AIDS and education, University of Zambia, Lusaka, Zambia; 2000
KMCC Uganda, Most at Risk Populations
– Long Distance Truck Drivers and HIV/AIDS in Uganda: Synthesis of Information and Evidence to Inform the Response. Synthesis Report, 2014
Campo JE, Jamjian J, Goulston C. HIV Antiretroviral Drug resistance. Journal of AIDS & Clinical Research 2012; 5(2); 2155-2161
Vaneet A, Reshma SR, Somashekar HS, Narendranath S, Keerthisagar J, Dinaka KR. Evaluation of the effect of the antiretroviral regimen (Zidovudine
+ Lamivudine + Nevirapine) on CD4 count, body weight and Hb % on HIV patients-a retrospective study. Journal of Interdisciplinary and Multidisciplinary Research 2015; 2 (5):177-185.
González Plaza JJ, Hulak N, Zhumadilov Z, Akilzhanova, A. Fever as an important resource for infectious diseases research. Intractable & rare diseases research 2016; 5(2), 97–102.
Palacios J, Santos J, Garcıa A, Castells E, Gonzalez M, Ruiz J.et al. Impact of highly active antiretroviral therapy on blood pressure in HIV-infected patients. A prospective study in a cohort of naive patients. HIV Medicine 2006; 7(1):10-15.
Röling J, Schmid H, Fischereder M, Draenert R, Goebel FD. HIV-Associated Renal Diseases and Highly Active Antiretroviral Therapy—Induced Nephropathy. Clinical Infectious Diseases 2006; 42(10):1488-1495
DOI: https://doi.org/10.15416/pcpr.v6i2.31829
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