Effects of pentagamavunon-0 (PGV-0) as alternative analgesics on orthodontic tooth movement in rats
Abstract
Introduction: Some analgesic drugs may have adverse effects on bone remodelling and, thus, on orthodontic tooth movement rate (OTM). GV-0 is synthesized by reacting vanillin and cyclopentanone catalyzed in acidic condition, and it has been revealed as a selective COX-2 inhibitor. This study was aimed to investigate the effect of pentagamavunon-0 (PGV-0), one of the curcumin analogues, on OTM. Methods: This study was conducted on 50 male Wistar rats (350-450 g) which were randomly divided into five groups (n = 10 each): 1) no treatment group (NT), 2) orthodontic treatment only (ORT), 3) ORT plus 0.4% sodium carboxymethyl cellulose (Na-CMC) analgesic carrier, 4) ORT plus 200 mg/kg BW Paracetamol (PCT) as the positive control, and 5) ORT plus PGV-0 (50 mg/kg BW (PGV-0). Results: Drug and day interaction was statistically significant on two-way ANOVA. Post-hoc analyses showed that OTM increased from day 3 to 7 in all orthodontic groups over the same distance (p>0.05). Maximum OTM was found on day 6, which was significantly farther than the distance on day 4. On day 7, OTM was less than on day 6. OTM in all orthodontic groups, including in the PGV-0 group, was higher than in the NT group (p<0.05). No differences was seen in OTM between PGV-0 group and other orthodontic groups (p>0.05). Post-hoc analysis (intra days) revealed that OTM in PGV-0 and other orthodontic treatment groups increased. Conclusion: After a single orthodontic force, PGV-0 does not inhibit tooth movement in rats from day 1 to day 7. Therefore, it is possible to develop PGV-0 as an alternative analgesics during orthodontic therapy.
Keywords: Analgesic drug, orthodontics, tooth movement, curcumin.
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Mayahara K, Yamaguchi A, Takenouchi H, Kariya T, Taguchi H, Shimizu N. Osteoblasts stimulate osteoclastogenesis via RANKL expression more strongly than periodontal ligament cells do in response to PGE2. Arch Oral Biol. 2012; 57(10): 1377–84. DOI: 10.1016/j.archoralbio.2012.07.009.
Sodagar A, Etezadi T, Motahhary P, Dehpour AR, Vaziri H, Khojasteh A. The effect of celecoxib on orthodontic tooth movement and root resorption in rat. J Dent (Tehran). 2013; 10(4): 303–11.
Yang YQ, Li XT, Rabie AB, Fu MK, Zhang D. Human periodontal ligament cells express osteoblastic phenotypes under intermittent force loading in vitro. J Biol Chem. 2006; 281(10): 6448–54. DOI: 10.2741/1835
Salmassian R, Oesterle LJ, Shellhart WC, Newman SM. Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2009; 135(4): 516–21. DOI: 10.1016/j.ajodo.2007.05.020.
Cottrell J, O’Connor JP. Effect of non-steroidal anti-inflammatory drugs on bone healing. Pharmaceuticals (Basel). 2010; 3(5): 1668–93. DOI: 10.3390/ph3051668.
Araujo AS, Fernandes ABN, Maciel JVB, Netto J de NS, Bolognese AM. New methodology for evaluating osteoclastic activity induced by orthodontic load. J Appl Oral Sci. 2015; 23(1): 19–25. DOI: 10.1590/1678-775720140351.
Lee W. Experimental study of the effect of prostaglandin administration on tooth movement-With particular emphasis on the relationship to the method of PGE1 administration. Am J Orthod Dentofac Orthop. 1990; 98(3): 231–41. DOI: 10.1016/s0889-5406(05)81600-2.
Warner TD, Mitchell JA. Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum. Proc Natl Acad Sci. 2002; 99(21): 13371–3. DOI: 10.1073/pnas.222543099.
Sari E, Olmez H, Gurton AU. Comparison of some effects of acetylsalicylic acid and rofecoxib during orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2004; 125(3): 310–5. DOI: 10.1016/S0889540603009144.
Meeran NA. Biological response at the cellular level within the periodontal ligament on application of orthodontic force–An update. J Orthod Sci. 2012; 1(1): 2–10. DOI: 10.4103/2278-0203.94769.
Arias OR, Marquez-Orozco MC. Aspirin, acetaminophen, and ibuprofen: Their effects on orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2006; 130(3): 364–70. DOI: 10.1016/j.ajodo.2004.12.027.
Kaur H, Bansal N, Abraham R. A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain. Angle Orthod. 2019; 89(4): 617-23. DOI: 10.2319/080518-570.1
Paul AD, Chauhan CK. Study of usage pattern of nonsteroidal anti-inflammatory drugs (NSAIDs) among different practice categories in Indian clinical setting. Eur J Clin Pharmacol. 2005; 60(12): 889–92. DOI: 10.1007/s00228-004-0849-6.
Reksohadiprodjo MS, Timmerman H, inventors; Universitas Gadja Mada, assignee. Derivatives of benzilidine cyclohexanone, benzilidine cyclopentanone, and benzilidine acetone and their synthesis. United States patent US 6,541,672. 2003 Apr 1.
Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol. 2008; 76(11): 1590–611. DOI: 10.1016/j.bcp.2008.08.008.
Ritmaleni. Synthesis of pentagamavunon-0 (PGV-0): An improved technique. Int J Pharm Sci Rev Res. 2016; 39(1): 9–11.
Dewi WR. Analgesic Effect of Pentagamavunon-0 (PGV-0) in Female DDY mice [minor thesis]. Yogyakarta: Gadjah Mada University; 2003.
Nurrochmad A, Margono SA, Sardjiman, Hakim AR, Ernawati, Kurniawati E. Hepatoprotective and antioxidant activity of pentagamavunon-0 against carbon tetrachloride-induced hepatic injury in rats. Asian Pac J Trop Med. 2013; 6(6): 438–42. DOI: 10.1016/S1995-7645(13)60070-X.
Keles A, Grunes B, Difuria C, Gagari E, Srinivasan V, Darendeliler MA. Inhibition of tooth movement by osteoprotegerin vs pamidronate under conditions of constant orthodontic force. Eur J Oral Sci. 2007; 131–6. DOI: 10.1111/j.1600-0722.2007.00433.x
Van Leeuwen EJ, Maltha JC, Kuijpers-Jagtman AM. Tooth movement with light continuous and discontinuous forces in beagle dogs. Eur J Oral Sci. 1999; 107(6): 468-74. DOI: 10.1111/j.1600-0722.2007.00433.x.
Von Bohl M, Maltha JC, Von Den Hoff JW, Kuijpers-Jagtman AM. Focal hyalinization during experimental tooth movement in beagle dogs. Am J Orthod Dentofac Orthop. 2004; 125(5): 615–23. DOI: 10.1016/j.ajodo.2003.08.023
Von Böhl M, Maltha J, Von Den Hoff H, Kuijpers-Jagtman AM. Changes in the periodontal ligament after experimental tooth movement using high and low continuous forces in beagle dogs. Angle Orthod. 2004; 74(1): 16–25. DOI: 10.1043/0003-3219(2004)074<0016:CITPLA>2.
Pilon JJ, Kuijpers-Jagtman AM, Maltha JC. Magnitude of orthodontic forces and rate of bodily tooth movement: An experimental study. Am J Orthod Dentofacial Orthop. 1996; 110(1): 16-23. DOI: 10.1016/s0889-5406(96)70082-3
Von Böhl M, Kuijpers-Jagtman AM. Hyalinization during orthodontic tooth movement: a systematic review on tissue reactions. Eur J Orthod. 2009; 31(1): 30-6. DOI: 10.1093/ejo/cjn080
Shetty N, Patil AK, Ganeshkar SV, Hegde S. Comparison of the effects of ibuprofen and acetaminophen on PGE2 levels in the GCF during orthodontic tooth movement: A human study. Prog Orthod. 2013; 14(1): 1–5.
Kotake S, Yago T, Kawamoto M, Nanke Y. Effects of NSAIDs on differentiation and function of human and murine osteoclasts - Crucial “Human Osteoclastology.” Pharmaceuticals (Basel). 2010; 3(5): 1394–410.
Williams LJ, Pasco JA, Henry MJ, Sanders KM, Nicholson GC, Kotowicz MA, et al. Paracetamol (acetaminophen) use, fracture and bone mineral density. Bone. 2011;48(6):1277–81.
Wallace JL, McKnight W, Reuter BK, Vergnolle N. NSAID-Induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology. 2000;119(3):706–14.
Lin CH, Jee WSS, Ma YF, Setterberg RB. Early effects of prostaglandin E2 on bone formation and resorption in different bone sites of rats. Bone. 1995 Oct;17(4 Suppl):255S-259S. DOI: 10.1016/8756-3282(95)00300-3
Nefussi JR, Baron R. PGE2 stimulates both resorption and formation of bone in vitro: Differential responses of the periosteum and the endosteum in fetal rat long bone cultures. Anat Rec. 1985;211(1):9–16.
Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG. The role of prostaglandins in the regulation of bone metabolism. Clin Orthop Rel Res. 1995;(313):36–46.
Patrignani P, Panara MR, Greco A, Fusco O, Natoli C, Iacobelli S, et al. Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J Pharmacol Exp Ther. 1994;271(3):1705–12.
Baigent C, Patrono C. Selective cyclooxygenase 2 inhibitors, aspirin, and cardiovascular disease: A reappraisal. Arthritis Rheum. 2003;48(1):12–20.
Sardjiman. Synthesis of some new series of curcumin analouges, anti-oxidative, anti-inflammatory, anti-bacterial acitivities and qualitative structure-activity-relationship, Disertation, 2000, Universitas Gadjah Mada
Asefi S, Seifi M, Fard G, Lotfi A. Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats. Dent Res J (Isfahan). 2018;15(1):40.
Adhyatmika A, Ronny M, Hilda I, Nanoparticle Preparation of Pentagamavunon-0 Using Medium Viscous Chitosan Matrix Cross Linked by Sodium Tripolyphosphate Through Ionic Gelation Mechanism as Anti-Inflammatory Candidate. Majalah Farmaseutik. 2017;13(2):65-7
DOI: https://doi.org/10.24198/pjd.vol31no3.20995
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