Clinical features of oral cavity of patients with non-Hodgkin’s lymphoma undergoing chemotherapy

Diptakanya Murdi Suroso, Tenny Setiani Dewi, Trinugroho Heri Fadjari

Abstract


Introduction: Non-Hodgkin`s lymphoma is one of hematologic malignancy that responds to chemotherapy. Chemotherapy agent can cause oral complication such as oral mucositis, hemorrhage, xerostomia, hyposalivation and periodontitist. The purpose of this study is to determine the clinical feature of the oral cavity in patients with non-Hodgkin`s lymphoma whose underwent chemotherapy  Method: This study used an observational descriptive method. This type of research is observational descriptive. The study population was non-Hodgkin’s lymphoma sufferers who were undergoing chemotherapy at the Hematology and Medical Oncology Outpatient Installation Division of Internal Medicine at Hasan Sadikin Hospital Bandung. The study sample was taken by consecutive sampling method The numbers of samples in this study were 30 people according to predetermined criteria. Result: The result shows that all samples have abnormalities of the oral cavity that patients who have an abnormality are amounted to 20% and patients who have more than one kind of oral abnormalities amounted to 80%. An abnormality of the oral cavity that the most often found in this study is xerostomia with hyposalivation. Conclusion: Clinical feature of the oral cavity in patients with non-Hodgkin`s lymphoma whose underwent chemotherapy are abnormalities in the oral cavity, where the number of samples that experienced more than one type of oral cavity abnormality was greater when compared to the number of samples with a kind of abnormality. Oral cavity. Most of the samples studied had oral cavity abnormalities in the form of serostomia accompanied by hyposalivation.


Keywords


Abnormality of oral cavity, chemotherapy, lymphoma non-Hodgkin’s.

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References


Benvie. 2010. Limfoma non-hodgkin. Available at: http://doctorology.net/?p=380 (diakses tanggal 16 Mei 2011).

Mohan, H. 2005. Essential Pathology for Dental Students. 3rd Ed. New Delhi:

Jaypee Brothers Med Publishers. 520,524-5,532 pp.

Markus R; John W.S; and Michael E.W. 2007. Lymphoma Pathology, Diagnosis and Treatment. New York : Cam-bridge University Press. 3,6-11,25 pp

Marcucci, F and M. Alfonso 2010. Hepatitis viruses and non-hodgkin lymphoma: epidemiology, mechanism of tumor-igenesis and therapeutic opportunities. Blood 117(6):1792-1798. Available at: http://bloodjournal.hematology li-brary.org/content/early/2010/10/19/blood-2010-06-275818(diakses tanggal 11 Mei 2011).

Fauci, A.S; E. Braunwald; D.L. Kasper; S.L. Hauser; D.L. Longo; J.L. Jameson; and J. Loscalzo. (ed.). 2009. Har-rison`s Manual of Medicine. 17th Ed. New York: The McGraw-Hills Companies. 340, 352-5, 358-9 pp.

Bower M; M. Fisher; T. Hill; I. Reeves; J. Walsh; C. Orkin; A.N. Phillips; L. Bansi; R. Gilson; P. Easterbrook; M. Johnson; B. Gazzard; C. Leen; D. Pillay; A. Schwenk; J. Anderseon; K. Porter; M. Gompels; and C.A. Sabin. 2009. CD4 counts and the risk of systemic non-hodgkin`s lymphoma in individual with HIV in the UK. Haematol 94 (6): 875-880. Available at: http://www.haematologica.org/content/94/6/ 875.full.pdf+html (diakses tanggal 13 Mei 2011).

Robert, S. 2006. Lymphoma risk in psoriasis: results of the PUVA follow-up study. Arch Dermatol 142:1132-1135. Available at: http://archderm.ama-assn.org/cgi/reprint/142/9/1132 (diakses tanggal 13 Mei 2011).

Felix. 2006. Sistem kekebalan tubuh itu justru mengganas. Farmacia 6 (5): 12.

Available at: http://www.majalah-farmacia.com/rubrik/one_news.asp?ID

News=374 (diakses tanggal 13 Mei 2011).

Baquiran, D.C. 2001. Cancer Chemotherapy Handbook. 2nd Ed. Philadelphia: Lippincot. 3, 85 pp.

Yarbro, C.H; D, Wujcik; and B.H, Gobel. 2011. Cancer Nursing Principles and Practice. 7th Ed. Sudbury : Jones and Bartlett Publishers. 482-3, 466, 1463, 1473 pp.

DeVita, V.T. Jr; T. S. Lawrence; and S. A. Rosenberg. (ed.). 2008. DeVita Hellman & Roosenberg Principles & Practice of Oncology. 8th Ed. 447-53,546, 2100, 2655-7 pp.

Yagiela, J.A; Frank, J.D; and Enid, A.N. 2004. Pharmacology and Therapeutics for Dentistry. 5th Ed. St Louis: Mos-by, Inc. 797-800 pp.

Sonis, S.T; Robert C.F; and Leslie F. 1995. Principles and Practice of Oral Medicine. 2nd Ed. Philadelphia: WB Saun-ders Company. 426-447

Greenberg, M. S and M. Glick. (ed.). 2003. Burket`s Oral Medicine Diagnosis & Treatment. 10th Ed. Ontario: BC Decker Inc.

Seymour, R.A. 2010. Malignant Disease and the Delivery of Dental Care. Dent Update 37 (1): 20-2, 25-6. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/20218458 (diakses tanggal 16 Mei 2011).

Fischer, D.J. 2008. Management of patient who have undergone head and neck cancer therapy. Dent Clin North Am 52 (1): 39-60. Available at: http://www.mendeley.com/research/management-patients-undergone-head-neck-cancer-therapy/ (diakses tanggal 16 Mei 2011).

Wong, F. 2009. A survey of clinicians: prioritization of dental treatment in leukemia patient prior to chemotherapy. Int J Prosthodont 22(3): 303-6. Available at: http://www.dentalarticles.com/search/24.php (diakses tanggal 16 Mei 2011).

Sastroasmoro, S. 2002. Dasar-Dasar Metodologi Klinis. 2nd Ed. Jakarta:

Perpustakaan Nasional RI: Katalog Dalam Terbitan. 80-85 pp.

Tawi, M. 2011. Konsep dasar tentang stress. Available at: http://syehaceh. wordpress.com/2011/08/22/konsep-dasar-tentang-stress/ (diakses tanggal 22 Febuari, 2012).

Valentino, R. 2010. Stress hormone receptors less adaptive in female brain. National Institute of Mental Health. Available at: http://www.nimh.nih.gov/ science-news/2010/stress-hormone-receptors-less-adaptive-in-female-brain.shtml (diakses tanggal 22 Febuari 2012).

Boyles, S. 2003. Estrogen is involved in stress response. Available at: http://www. webmd.com/depression/news/20031203/estrogen-is-involved-in-stress-response (diakses tanggal 21 Febuari 2012).

American Cancer Society. 2010. Non-hodgkin lymphoma. Available at: http:// docu-ments.cancer.org/acs/groups/cid/documents/webcontent/003126-pdf.pdf (diakses tanggal 26 Desember 2011).

Morrison, V.A. 2002. Non-Hodgkin’s Lymphoma in the Elderly. 277 pp. Available at: http://web.squ.edu.om/med-Lib/MED_CD/E_CDs/Malignant %20Lymphomas/docs/ch16.pdf (diakses tanggal 11 Maret 2012).

Broadfield, L; J. Hamilton; and G. Sophie. 2006. Best practice guidelines for the management of oral complication from cancer therapy. Supportive Care Cancer Site Team, Cancer Care Nova Scotia. 49, 74 pp. Available at: http://www.cancercare.ns.ca/site-cc/media/cancercare/Oral_Care DPV _FINAL.pdf (diakses tanggal 8 Mei 2011).

Bartels, C.L. 2001. Xerostomia information for dentist. Available online at: http:// oralcancerfounda-tion.org/dental/xerostomia.html (diakses tanggal 9 Januari 2012).

Hasibuan, S. 2002. Keluhan mulut kering ditinjau dari faktor penyebab, manifestasi dan penanggulangannya. Fakultas Kedokteran Gigi Sumatera Utara. 2-4 pp. Available at: http://library.usu.ac.id/download/fkg/fkg-sayuti.pdf (diakses tanggal 10 Maret 2012).

Lukisari, C dan Kusharjanti. 2010. Xerostomia: Salah Satu Manifestasi Oral Diabetik. Available at:http://canelukisari.blogspot.com/2010/04/ xerostomia-salahhttp://professional.cancerconsultants.com/currentoncology.a spx?id=33386-satu-manifestasi-oral.html (diakses tanggal 17 Mei 2011).

Fox, P.C. 2008. Xerostomia: recognition and management. American Dental Hygienists’ Association. 2 pp. Available at: http://www.adha.org/downloads /Acc0208Supplement.pdf (diakses tanggal 11 Maret 2008).

Collins, F.M. 2009. Tobacco cessation and the impact of tobacco use on oral health. 3-4 pp. Available at: http://chfs.ky.gov/NR/rdonlyres/31D160F5-8270-4BB1-BB5F-A4199108A499/0/TobaccoCessation.pdf(diakses tang-gal 16 Maret 2012).

Scully, C. 2003. Drug effects on salivary glands: dry mouth. Oral Diseases 9 (10): 165–176. Available at: http://onlinelibrary.wiley.com/doi/10.1034/j.1601-0825.2003.03967.x/pdf (diakses tanggal 11 Maret 2012).

Valimaa, H; S, Savolainen; T, Soukka; P. Silvoniemi; S. Makela; H. Kujari; J.A. Gustafsson; and M. Laine. 2004. Es-trogen receptor-β is the predominant estrogen receptor subtype in human oral epithelium and salivary glands. J En-docrinol 180: 55-62. Available at: http://joe. endocrinology-journals.org/content/180/1/55 .full.pdf (diakses tanggal 19 Maret 2012).

Burt, B.A. 1994. Periodontitis and aging: reviewing recent evidence. J Am Dent Assoc 125 (3): 273-279. Available at: jada.ada.org/content/125 /3/273.abstract (diakses tanggal 11 Maret 2012).

Buencamino, M.C; L. Palomo; and H. L. Thacker. 2009. How menopause affects oral health, and what we can do about it. Cleveland Clinic Journal of Medicine 76 (8): 467-475. Available at: http://www.atlantadentalspa.com /articles/Perio_and_menopause.PDF (diakses tangaal 19 Maret 2012).

Epstein, J. B. 2007. Mucositis in the cancer patient and immunosuppressed host. Infect Dis Clin N Am 21:503–522. Available at: http://linkinghub

Kostler, W.J; Michael, H; Catharina, W; and C. C. Zielinski. 2001. Oral mucositis complicating chemotherapy and/or radiotherapy: option for prevention and treatment. CA Cancer J Clin 51; 290-315. Available at: http:// onlineli-brary.wiley.com/doi/10.3322/canjclin. 51.5.290/pdf (diakses tanggal 17 Mei 2011).

Ilgenli, T; Hale, O; and Kamer, U. 2001. The acute effects of chemotherapy upon the oral cavity: prevention and management. Turk J Canc 31(3): 94-9. Available at: http://www.turkjcancer.org/pdf/pdf_TJC_36.pdf (diakses tanggal 27 Mei 2011)

Cairo, M.S. 2000. Dose reduction and delays: limitations of myelosupressive chemotherapy. Oncology 14 (8): 21-31. Available at: http://www. cancernetwork.com/display/article/10165/92613 (diakses tanggal 11 Maret 2012).

Kaushansky, K; E. Beutler; U. Seligsohn; M. Litchman; T.J. Kipps; and J. Prchal. (ed.). 2010. Williams Hematology. 8th Ed. New York: Mc-Graw-Hill Companies, Inc. 1721 pp.

Tirgan, M.H. 2011. Thrombocytopenia. Available at: www.tirgan.com/thrpeniahtm (diakses tanggal 11 Maret 2012).

Tilly, H; E. Lepage; B. Coiffier; M. Blanch; R. Herbretch; A. Bosly; M. Attal; G. Fillet; C. Guettier; T. Molina; C. Gisselbretch; and F. Reyes. 2003. Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma. Blood 102: 4284-4289. Available at: http://bloodjournal.hematologylibrary. org/content/102/13/4284.full.pdf (diakses tanggal 17 maret 2012).




DOI: https://doi.org/10.24198/pjd.vol25no2.26798

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