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Email this article Formulation and physical stability analysis of red beetroots (Beta vulgaris l.) effervescent granules
Abstract
ABSTRACT
Introduction: Red beetroots (Beta vulgaris L.) are a natural ingredient rich in nutrients and provide various notable health benefits. In dentistry, red beetroots have the potential to act as a plaque-disclosing agent. Previous studies showed that red beetroot preparation in gelform is more effective compared to chewable tablets, but has significant drawbacks in taste. Effervescent granules have the potential to conceal the unpleasant taste of beetroot substances. This study aims to determine the ideal formula and evaluate the physical properties and stability of effervescent granules made from red beetroot extract. Methods: This was an experimental design study with descriptive analysis. The maceration method was used to extract the red beetroot constituents. Fresh fruits were collected, air-dried, and macerated with 96% ethanol twice. The filtrates were then concentrated. The wet granulation method was used to formulate effervescent granules. The samples were grouped into formula 1 (F1), formula 2 (F2), and formula 3 (F3) using 1%, 3%, and 4% red beetroot extract, respectively. All sample groups were analyzed for physical stability, namely: organoleptic, flowability, density, dissolving time, and pH tests. Results: All samples surpassed the sensory evaluation for physical properties. Formula 1 (1%) and formula 2 (3%) models passed all the physical stability tests. Meanwhile, the 4% formula (F3) failed two physical tests. F1 (1%) samples also showed lighter brown color for its lower beetroot extract concentration, indicating under-qualification as dental plaque staining materials. Therefore, 3% concentration (F2) has the best formulation regarding physical properties and stability. Conclusion: Formulas F1 and F2 have the best physical properties and stability by passing all the tests, while Formula 3 failed the organoleptic and flow rate tests.
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Hidayat F, Hidayat F, Farida A, Ermaya D, Sholihati. Kajian Penambahan Pasta Umbi Bit Merah (Beta vulgaris L) dan Tepung Kacang Hijau (Phaseolus radiatus L) dalam Pembuatan Roll Cookies. Rona Teknik Pertanian [Internet]. 2019;v. 12(1):1-11–2019 v.12 no.1. DOI: 10.17969/rtp.v12i1.13216 (Indonesian language)
Khosasi W, Felim J, Lukita S, Sim M, Wijaya S, Florenly. Stronger Antibacterial Efficacy of Red Beetroots Compared to Red Dragon Fruit Peels Extract on Streptococcus mutans. In: InHeNce 2021 - 2021 IEEE International Conference on Health, Instrumentation and Measurement, and Natural Sciences. Institute of Electrical and Electronics Engineers Inc.; 2021. DOI: 10.1109/InHeNce52833.2021.9537271
Babarykin D, Smirnova G, Pundinsh I, Vasiljeva S, Krumina G, Agejchenko V. Red Beet ( Beta vulgaris ) Impact on Human Health. J Biosci Med (Irvine). 2019 Jan 1;07:61–79. DOI: 10.4236/jbm.2019.73007
Tan ML, Hamid SBS. Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review. J Cancer Prev [Internet]. 2021/03/30. 2021 Mar;26(1):1–17. DOI: 0.15430/JCP.2021.26.1.1
Milton-Laskibar I, Martínez JA, Portillo M. Current Knowledge on Beetroots Bioactive Compounds. Role of Nitrate and Betalains in Health and Disease Foods. 2021;10:6. DOI: 10.3390/foods10061314
Devadiga D, Ahipa TN. Betanin: A Red-Violet Pigment - Chemistry and Applications. Vol. 10, IntechOpen. 2020. 5772 p. DOI: 10.5772/intechopen.88939
Ferrara L. Food Benefits and Nutraceutical Properties of the Red Beet. Austin Journal of Nutrition & Metabolism [Internet]. 2020;7(3). Available from: www.austinpublishinggroup.com
Saula LS, Hermawan KA, Hasna Vina Luthfiana, Lubis Christina Febiola, Putri G, Andini SD. Buah bit (beta vulgaris l.) sebagai antianemia. HSG Journal [Internet]. 2020 [cited 2023 Feb 22];5(2):14–6. Available from: https://journal.unsika.ac.id/index.php/HSG/article/view/4926 (Indonesian language)
Purbaningtyas E, Yuliani F, AP. A. Disclosing Agent from Red Dragon Fruit Peel as Dental Plaque Indicator. Odonto Dental Journal. 2020;7(1):31–9. DOI: 10.30659/odj.7.1.31-39
Mangiri BS, Yani S, Anitasari S. Sari Buah Naga Super merah (Hylocereus costaricensis) Sebagai Pewarna Alami Plak Gigi. Jurnal Material Kedokteran Gigi. 2018 Aug 6;7(1):28. DOI: 10.32793/jmkg.v7i1.278 (Indonesian language)
Halimfanezi L, Asra R. A Review: Analysis of Betacyanin Levels in Various Natural Products. Asian Journal of Pharmaceutical Research and Development [Internet]. 2020 Oct 15;8(5). Available from: https://ajprd.com/index.php/journal/article/view/846. DOI: 10.22270/ajprd.v8i5.846
Fione VR, Adam JDZ. Extract Purple Sweet Potatoes (Ipomea batatas L.) as Natural Dyes in Dental Plaque Staining. Jurnal Ilmiah Perawat Manado (Juiperdo). 2021 Jan 8;8(02):130–41. DOI : 10.47718/jpd.v8i02.1197
Oktaviani N, Haryani W, Sutrisno. Perbedaan Pengolesan Ekstrak Buah Bit Dan Disclosing Solution Terhadap Skor Plak Pada Siswa Sdn. Jurnal Gigi Dan Mulut. 2018;2(2):19–22. (Indonesian language)
Jung I hee, Yeon KH, Song HR, Hwang YS. Cytotoxicity of dental disclosing solution on gingival epithelial cells in vitro. Clin Exp Dent Res [Internet]. 2020 Dec 1;6(6):669–76. DOI: 10.1002/cre2.321
Erwin E, Asmawati A, Sofyan S. Perbedaan Indeks Plak pada Pemeriksaan dengan Bahan Disclosing Solution dan Biji Kesumba (Bixa orellana). Jurnal Surya Medika. 2021 Feb 15;6:5–9. DOI: 10.33084/jsm.v6i2.1535 (Indonesian language)
Nurilawaty V, Priharti D, Sukmawati AE, Sasongko BG, Tulandi SM, Purnama T. Formulation of Roselle Flower Extract Gel (Hibiscus sabdariffa L) as a Disclosing Solution. Asian Journal of Pharmaceutical Research and Development. 2022 Oct 14;10(5):33–7. DOI: 10.22270/ajprd.v10i5.1180
Ratnaningsih DA, Nurilawaty V, Subiyandono. Extract Formulation and Effectiveness of Beta vulgaris L. as dental plaque solution disclosing. International Journal of Medical and Health Research. 2018 Feb 1;4(2):141–3.
Pawar HA, Joshi PR. Development and Evaluation of Taste Masked Granular Formulation of Satranidazole by Melt Granulation Technique. J Pharm (Cairo). 2014 Feb 12;2014:1–7. DOI: 10.1155/2014/789676
Grajang IB, Wahyuningsih I. Formulation of Sechium edule Extract Effervescent Granule with the Variation of Citric Acid, Tartrate Acid and Sodium Bicarbonate. In: Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018). Scitepress; 2019. p. 54–60. DOI: 10.5220/0008239300540060
Wati S, Saryanti D. Effervescent Granule Formulation of Bitter Melon Extract (Momordica charantia L.) with Gelatin as A Wet Granulation Binder. Journal of Nutraceuticals and Herbal Medicine [Internet]. 2019;2(1):20–8. Available from: http://journals.ums.ac.id/index.php/jnhm. DOI: 10.23917/jnhm.v2i1.8052
Rusita YD, Suhendriyo S. Optimalisasi Campuran CMC Na-Gelatin untuk Pembuatan Granul Effervescent Ekstrak Buah Bit (Beta Vulgaris L) dengan Metode Simplex Lattice Design. Jurnal Terpadu Ilmu Kesehatan. 2015;4(2). (Indonesian language)
Lynatra C, Elisya Jurusan Farmasi Y, Kesehatan Kemenkes P. Formulation of Effervescent Tablet of Temulawak Extract (Curcuma xanthorrhiza Roxb.) With Variation of Stevia as Sweetener. SANITAS: Jurnal Teknologi dan Seni Kesehatan [Internet]. 2018 Dec 1 [cited 2023 Feb 22];9(2):72–82. Available from: https://sanitas.e-journal.id/index.php/SANITAS/article/view/20181201-lynatra. DOI: 10.36525/sanitas.2018.9
İpci K, Öktemer T, Birdane L, Altıntoprak N, Bayar Muluk N, Passali D, et al. Effervescent tablets: a safe and practical delivery system for drug administration. ENT Updates. 2016 Apr 1;6(1):46–50. DOI: 10.2399/jmu.2016001009
Liger-Belair G. Effervescence in champagne and sparkling wines: From grape harvest to bubble rise. Eur Phys J Spec Top [Internet]. 2017;226(1):3–116. DOI: 10.1140/epjst/e2017-02678-7
Sridevi G, Korangi V, Latha SM. Review on a novel approach in Recent Advances of granulation techniques and technologies. Res J Pharm Technol [Internet]. 2017 Feb 28 [cited 2023 Feb 22];10(2):606–17. Available from: https://rjptonline.org/AbstractView.aspx?PID=2017-10-2-46. DOI: 10.5958/0974-360X.2017.00119.6
Pratiwi RD, Murrukmihadi M, Aisiyah S. Pengaruh Gelatin Sebagai Bahan Pengikat Terhadap Sifat Fisik Tablet Kunyah Kelopak Bunga Rosella (Hibiscus sabdariffa L.) dengan Granulasi Basah. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) [Internet]. 2018 Jan 17 [cited 2023 Feb 22];14(1):31–40. Available from: https://jurnalnasional.ump.ac.id/index.php/PHARMACY/article/view/1381 (Indonesian language)
Rani KC, Parfati N, Nie J, Kurniawan I, NPW. K. The development of Moringa leaves effervescent granules with an effervescent agent of citric acid and sodium bicarbonate. Pharmaciana. 2021;11(2):225–40. DOI: 10.12928/pharmaciana.v11i2.20873
Nugraha SE, Yuandani, Nasution ES, Syahputra RA. Investigation of phytochemical constituents and cardioprotective activity of ethanol extract of beetroot (Beta vulgaris. L) on doxorubicin induced toxicity in rat. Rasayan Journal of Chemistry. 2020 Apr 1;13(2):973–8. DOI: 10.31788/RJC.2020.1325601
United States Pharmacopeial. USP 30, Volume 1 [Internet]. US Pharmacopeia. United States Pharmacopeial Convention; 2007 [cited 2023 Feb 22]. 1248 p. Available from: http://books.google.com/books?id=q31qAAAAMAAJ&pgis=1
Sholikhati A, Rahmawati RP, Kurnia SD. Analisis mutu fisik granul ekstrak kulit manggis dengan metode granulasi basah. Indoneisa Jurnal Farmasi Seminar Nasional Conference On Science, Health, Economics, Education And Technology. 2022;7(1):1–9. DOI: 10.26751/ijf.v7i1.1421 (Indonesian language)
Santosa L, Yamlean PVY, Supriati HS. Formulasi granul effervescent sari buah jambu mete (Annacardium ocidentale L.). PHARMACON [Internet]. 2017 Jul 5 [cited 2023 Feb 22];6(3). Available from: https://ejournal.unsrat.ac.id/v3/index.php/pharmacon/article/view/16578 (Indonesian language). DOI: https://doi.org/10.35799/pha.6.2017.16578
Reddy RS, Ramachandra CT, Hiregoudar S, Nidoni U, Ram J, Kammar M. Influence of processing conditions on functional and reconstitution properties of milk powder made from Osmanabadi goat milk by spray drying. Small Ruminant Research [Internet]. 2014 [cited 2023 Feb 22];119(1–3):130–7. DOI: 10.1016/j.smallrumres.2014.01.013
Wrasiati LP, Widyantari MD, Putra INK. Characteristics of Effervescent Granules Extract of Kenikir (Cosmos caudatus Kunth) Leaf with Various Acid Compositions as Alternative Functional Beverage Products. Int J Curr Microbiol Appl Sci. 2021 Aug 20;10(8):1–8. DOI: 10.20546/ijcmas.2021.1008.001
Aslani A, Fattahi F. Formulation, characterization and physicochemical evaluation of potassium citrate effervescent tablets. Adv Pharm Bull. 2013;3 1:217–25. DOI: 10.5681/apb.2013.036
Herlina, Kuswardhani N, Belgis M, Tiara A. Characterization of Physical and Chemical Properties of Effervescent Tablets Temulawak ( Curcuma zanthorrhiza ) in the Various Proportion of Sodium Bicarbonate and Tartaric Acid. In: E3S Web of Conferences. EDP Sciences; 2020. DOI: 10.1051/e3sconf/202014203006
Persson AS. Flow and Compression of Granulated Powders: The Accuracy of Discrete Element Simulations and Assessment of Tablet Microstructure. 2013;
Hiremath P, Nuguru K, Agrahari V. Chapter 8 - Material Attributes and Their Impact on Wet Granulation Process Performance. In: Narang AS, Badawy SIF, editors. Handbook of Pharmaceutical Wet Granulation [Internet]. Academic Press; 2019. p. 263–315. Available from: https://www.sciencedirect.com/science/article/pii/B9780128104606000129. DOI: 10.1016/B978-0-12-810460-6.00012-9
Morkhade DM. Comparative impact of different binder addition methods, binders and diluents on resulting granule and tablet attributes via high shear wet granulation. Powder Technol. 2017 Oct 1;320:114–24. DOI: 10.1016/j.powtec.2017.07.038
Syahrina D. Optimization of the Combination of Citric Acid and Tartaric Acid as an Acidifying Agent in Effervescent Tablets of Purple Sweet Potato Extract (Ipomoea batatas L). Jurnal Surya Medika (JSM) [Internet]. 2021;7(1):156–72. Available from: http://journal.umpalangkaraya.ac.id/index.php/jsmCC-BY-SALicense. DOI: https://doi.org/10.33084/jsm.v7i1.2651
Salomy Monica Diyya A, Vinay Thomas N. Formulation and evaluation of metronidazole effervescent granules. Int J Pharm Sci Res [Internet]. 2018;9(6):2525. DOI: 10.13040/IJPSR.0975-8232.9
Patel SG, Siddaiah M. Formulation and evaluation of effervescent tablets: a review. Journal of Drug Delivery and Therapeutics. 2018;8(6). DOI: 10.22270/jddt.v8i6.2021
Firodiya S R, Bairagi S M, Kharat S S, Mote G D. Formulation and evaluation of effervescent tablet of Valsartan. International Journal of Pharmaceutics & Drug Analysis International Journal Of Pharmaceutics & Drug Analysis [Internet]. 2017;5:136–43. Available from: http://ijpda.com;
Prajapati BG, Mishra O. Concept, Manufacturing and Characterization of Effervescent Tablets: A Review. SunText Review of Pharmaceutical Sciences. 2021;02(01). DOI: 10.51737/2766-5232.2021.010
Yusof YA, Chin NL, Anuar MS, Nor CR, Aziz MG. Tabletting characteristics of the selected Malaysian herbs. Journal of Medicinal Plants Research [Internet]. 2012;6(43):5570–81. Available from: http://www.academicjournals.org/JMPR. DOI: 10.5897/JMPR11.1376
Chinwan D, Castell-Perez M. Effect of conditioner and moisture content on flowability of yellow cornmeal. Food Sci Nutr. 2019 Sep 2;7. DOI: 10.1002/fsn3.1184
DOI: https://doi.org/10.24198/pjd.vol35no2.47031
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