Effect coffee administration on alkaline phosphatase levels during relapse following orthodontic retention in rats: an experimental study

Septa Yumnaning Tyas, Muhamat Muhtar S Abdurrohman, Christina Mahardika, Moh Yusuf

Abstract


Introduction: Maintaining teeth in their corrected positions following orthodontic treatment can be extremely challenging. Coffee is one substance whose effects on relapse have been extensively studied. The aim of study is to analyze the effect of coffee administration on relapse after orthodontic retention by evaluating alkaline phosphatase levels. Methods: This experimental laboratory study enrolled SpraqueDawley rats, with brackets applied using Edgewise slot 0.022” system and a nickel-titanium open coil spring fixed between the lower central incisors for 14 days. Based on Federer’s formula, 36 SpraqueDawley rats were randomly divided by simple random sampling into four groups: Group 1 (no retention), Group 2(retention for 3 days), Group 3(retention for 7 days), and Group 4(retention for 2 weeks). The Spraque-Dawley rats in the four experimental groups were given aquadest, 50 mg, and 100 mg/kg coffee intake ad libitum. Orthodontic relapse was assessed by measuring changes in alkaline phosphatase levels between the lower central incisors (the relapse side). Changes in the distance between the central incisors during relapse were observed visually. Alkaline phosphatase levels, which serve as a predictor of recurrence, were determined using an enzyme-linked immunosorbent assay (ELISA). Data analysis was conducted with the Two-way analysis of variance (ANOVA) and a post hoc Tukey test. Results: Overall, we found that a longer retention period was associated with a slower rate of relapse and a shorter overall amount of relapse. In addition, inhibiting osteoclast formation using coffee also reduced orthodontic relapse. Alkaline phosphatase (ALP) and/or its biomarkers could serve as potential therapeutic targets in the prevention and treatment of orthodontic relapse, with changes observed at a value of 0.001. This demonstrates that coffee administration affects alkaline phosphatase levels during relapse after orthodontic retention. Conclusion: Coffee administration increased alkaline phosphatase levels during relapse after orthodontic retention in rats.

Keywords


Alkaline phosphatase levels, Caffeine, Relapse

Full Text:

PDF

References


Hadi AFN, Aghniya SN, Haidar GA, Sihombing WSM, Sutedjo A, Alhasyimi AA. Post-Orthodontic Relapse Prevention through Administration of a Novel Synthetic Carbonated Hydroxyapatite–Chitosan Hydrogel Derived from Blood Cockle Shell (Anadara granosa L.). Dent J. 2024;12(1). https://doi.org/10.3390/dj12010018

Herniyati, Devi LS, Prameswari N. Analysis of the Potency of Robusta Coffee (Coffea canephora) to Increase the Expression of FGF2, Collagen 1 and ALP in the Periodontal Ligament During Orthodontic Tooth Movement. Trends Sci. 2023;20(8):1–11. https://doi.org/10.48048/tis.2023.6440

Golshah A, Omidi K, Nikkerdar N, Ghorbani F. Effect of Caffeine Injection on Orthodontic Tooth Movement in Rats: An Experimental Study on Rats. Int J Dent. 2022;2022. https://doi.org/10.1155/2022/7204806

De Bernabé PGG, Montiel-Company JM, Paredes-Gallardo V, Gandía-Franco JL, Bellot-Arcís C. Orthodontic treatment stability predictors: A retrospective longitudinal study. Angle Orthod. 2017;87(2):223–229. https://doi.org/10.2319/053116-435.1

Chacón-Moreno A, Ramírez-Mejía MJ, Zorrilla-Mattos AC. Recidiva y movimiento dental involuntario después del tratamiento de ortodoncia en personas con retenedores fijos: Una revisión. Rev Científica Odontológica. 2022;10(3):e116. https://doi.org/10.21142/2523-2754-1003-2022-116

Elih. Relapse and retention after orthodontic treatment. Padj J Dent. 2015;27(3). https://doi.org/10.24198/pjd.vol27no3.13547

Paiva CLRS, Beserra BTS, Reis CEG, Dorea JG, Da Costa THM, Amato AA. Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review. Crit Rev Food Sci Nutr. 2019;59(4):652–663. https://doi.org/10.1080/10408398.2017.1386159

Huang GY, Choi SH, Jung HD, Kim HS, Hwang CJ, Lee KJ. Tissue-specific biomarkers in gingival crevicular fluid are correlated with external root resorption caused by constant mechanical load: an in vivo study. Clin Oral Investig. 2021;25(11):6321–6333. https://doi.org/10.1007/s00784-021-03932-6

Kenkre JS, Bassett JHD. The bone remodelling cycle. Ann Clin Biochem. 2018;55(3):308–327. https://doi.org/10.1177/0004563218759371

Gupta S, Chhina S, Arora SA. A systematic review of biomarkers of gingival crevicular fluid : Their predictive role in diagnosis of periodontal disease status Journal of Oral Biology and Craniofacial Research A systematic review of biomarkers of gingival crevicular fl uid : Their pre. J Oral Biol Craniofacial Res. 2019;8(2):98–104. https://doi.org/10.1016/j.jobcr.2018.02.002

Jo S, Han J, Lee YL, Yoon S, Lee J, Wang SE, et al. Regulation of osteoblasts by alkaline phosphatase in ankylosing spondylitis. Int J Rheum Dis. 2019;22(2):252–61. https://doi.org/10.1111/1756-185X.13419

Akbulut S, Yagci A, Yay AH, Yalcin B. Experimental investigation of effects of platelet-rich plasma on early phases of orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2019;155(1):71–79. https://doi.org/10.1016/j.ajodo.2018.03.015

Rasaei, Neda, Ghadiri, Ataollah, Peighan, Maryam, Rekabi, Atefe, Ataskhar N. Evaluation of alkaline phosphatase in gingival crevicular fluid and saliva of patients with periodontitis and healthy individuals. J Fam Med Prim Care. 2022;6(2):169–170. https://doi.org/10.4103/jfmpc.jfmpc_477_22

Abdul Ameer SA, Alhuwaizi AF. The Effect of Orthodontic Force on Salivary Levels of Alkaline Phosphatase Enzyme. J Baghdad Coll Dent. 2015;27(4):175–179. https://doi.org/10.12816/0024083

Alhasyimi AA, Pudyani PS. Effect of cocoa administration during orthodontic tooth movement on RUNX2, calcium levels, and osteoclast bone-resorbing activity in rats. J Pharm Pharmacogn Res. 2022;10(5):857–864. https://doi.org/10.56499/jppres22.1434_10.5.857

Marcucci G, Domazetovic V, Nediani C, Ruzzolini J, Favre C, Brandi ML. Oxidative Stress and Natural Antioxidants in Osteoporosis: Novel Preventive and Therapeutic Approaches. Antioxidants. 2023;12(2). https://doi.org/10.3390/antiox12020373

Syarif RD, Kusumaningsih T, Arundina I. Changes in osteoblast and osteoclast cell count after moringa oleifera leaf extract administration during orthodontic tooth movement. J Dentomaxillofacial Sci. 2020;5(2):98–102. https://doi.org/10.15562/jdmfs.v5i2.1081

Farahani M, Safavi SM, Dianat O, Khoramian Tusi S, Younessian F. Acid and Alkaline Phosphatase Levels in GCF during Orthodontic Tooth Movement. J Dent (Shiraz, Iran). 2015;16(3 Suppl):237–245. http://www.ncbi.nlm.nih.gov/pubmed/26535403%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4623837

Miao Y, Zhao L, Lei S,. Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-κB, and MAPK pathways. Front Pharmacol. 2024;15(June):1–14. https://doi.org/10.3389/fphar.2024.1405173

van Driel M, van Leeuwen JPTM. Vitamin D and Bone: A Story of Endocrine and Auto/Paracrine Action in Osteoblasts. Nutrients. 2023;15(3). https://doi.org/10.3390/nu15030480

Khalaf RM, Almudhi AA. The effect of vitamin D deficiency on the RANKL/OPG ratio in rats. J Oral Biol Craniofacial Res. 2022;12(2):228–232. https://doi.org/10.1016/j.jobcr.2022.02.004

Kurnia S, Prahasanti C, Hendro OV, Siki YO, Riawan W, Bargowo L. OPG and RANKL Signal Transduction in Osteoblast Regulation Post Application Extract Collagen in Osteogenesis. Res J Pharm Technol. 2022;15(6):2645–2649. https://doi.org/10.52711/0974-360X.2022.00442

Kobayashi T, Maruyama T, Yoneda T,. Effects of coffee intake on oxidative stress during aging-related alterations in periodontal tissue. In Vivo (Brooklyn). 2020;34(2):615–622. https://doi.org/10.21873/invivo.11815

Ngibad K, Yusmiati SNH, Merlina DM, Rini YP, Valenata V, Jannah EF. Comparison of Total Flavonoid, Phenolic Levels, and Antioxidant Activity between Robusta and Arabica Coffee. KOVALEN J Ris Kim. 2023;9(3):241–249. https://doi.org/10.22487/kovalen.2023.v9.i3.16506




DOI: https://doi.org/10.24198/pjd.vol36no3.57868

Refbacks

  • There are currently no refbacks.


 

Creative Commons License All publications by the Universitas Padjadjaran [e-ISSN: 2549-6212, p-ISSN: 1979-0201] are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.This license requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.

Visitor Stat