Prevalensi dan pola penyakit infeksi virus rongga mulut di RSUP Dr. Hasan Sadikin Bandung tahun 2013-2017
Prevalence and patterns of oral viral infection in Dr Hasan Sadikin Hospital Bandung in 2013-2017
Abstract
Pendahuluan: Terdapat sejumlah virus yang dapat menyebabkan infeksi daerah perioral, mulut, dan orofaring. Virus dapat menginisiasi infeksi, menyebar ke seluruh tubuh, dan bereplikasi berdasarkan sifat dan karakteristik virulensinya. Penyakit akibat virus dapat menyebabkan kerusakan sel secara langsung maupun dapat berupa reaksi sekunder. Virus yang menyerang rongga mulut dapat bermanifestasi diantaranya seperti vesikula dan ulser. Penelitian ini bertujuan untuk mengetahui prevalensi dan pola penyakit infeksi virus rongga mulut di RSUP Dr. Hasan Sadikin Bandung tahun 2013-2017. Metode: Penelitian deskriptif dengan menggambarkan prevalensi dan pola penyakit infeksi rongga mulut. Data yang dikumpulkan merupakan data sekunder berbentuk rekam medis pasien. Pengambilan sampel dilakukan dengan cara purposive sampling, dengan kriteria inklusi yaitu pasien dengan diagnosis infeksi virus rongga mulut di RSUP Dr. Hasan Sadikin Bandung tahun 2013-2017. Hasil: Penelitian ini menunjukkan total pasien rawat inap berjumlah 742 orang, didapatkan 21 pasien dengan infeksi virus rongga mulut, yang paling banyak ditemukan yaitu HSV-1 (66,67%), diikuti oleh infeksi HSV-2 (4,76%), CMV (9,52%), dan VZV sebanyak (19,05%). Sedangkan pada pasien rawat jalan yang berjumlah 531 orang didapatkan 58 pasien dengan infeksi virus rongga mulut, infeksi HSV-1 juga paling banyak ditemukan (91,38%), diikuti oleh infeksi CMV (1,72%), dan VZV (6,90%). Simpulan: Prevalensi infeksi virus rongga mulut sebanyak 2,83% pada pasien rawat inap dan sebanyak 10,92% pada pasien rawat jalan, dengan jumlah tertinggi yaitu infeksi HSV-1.
Kata kunci: Infeksi virus, orofasial, famili herpes virus
ABSTRACT
Introduction: Several viruses can cause infection of the perioral region, mouth, and oropharynx. Viruses can initiate infections, spread throughout the body, and replicate based on their virulence characteristics. Viral diseases can cause cell damage directly or can trigger a secondary reaction. Viruses that attack the oral cavity can manifest, such as vesicles and ulcers. This study was aimed to determine the prevalence and patterns of oral viral infection in Dr Hasan Sadikin Hospital Bandung in 2013-2017. Methods: Descriptive study was performed by describing the prevalence and pattern of oral infections. Data collected was secondary data in the form of patient medical records. Sampling was carried out by purposive sampling, with inclusion criteria, namely patients with a diagnosis of oral cavity virus infection in Dr Hasan Sadikin Hospital Bandung in 2013-2017. Results: This study showed a total of 742 inpatients, 21 patients with oral cavity infections, the most common were HSV-1 (66.67%), followed by HSV-2 infection (4.76%), CMV (9.52%), and VZV infections (19.05%). Whereas in total 531 outpatients, 58 patients were found with oral cavity infections, HSV-1 infections were also found the most (91.38%), followed by CMV (1.72%), and VZV infections (6.90%). Conclusion: The prevalence of oral cavity infection is 2.83% in inpatients and as many as 10.92% in outpatients, with the highest number being HSV-1 infection.
Keywords: Viral infection, orofacial, herpes virus familyKeywords
Full Text:
PDFReferences
Nair RG, Salajegheh A, Itthagarun A, Pakneshan S, Brennan MT, Samaranayake LP. Orofacial viral infections - An update for clinicians. Dent Update. 2014;41(6):518–24.
Rao KB. Herpes Viruses–An Overview. J Pharm 2014;4(10):39–41. Tersedia pada: http://www.iosrphr.org/papers/v4i10/G041039041.pdf.
Scully C, Epstein J, Porter S, Cox M. Viruses and chronic disorders involving the human oral mucosa. Oral surgery, oral medicine, and oral pathology 1991;72:537-544.
Ballyram R, Wood N, Lemmer J, Feller L. Oral diseases associated with human herpes viruses: aetiology, clinical features, diagnosis and management. South African Dental Journal 2016;71(6):253-9.
Berhman R., Vaughan V. Nelson Textbook Of Pediatrics. 12th ed. Philadelphia: W.B. Saunders Company; 1983.
Jenkins FJ, Hoffman LJ. Overview of Herpesviruses. Infectious Causes of Cancer 2000;(7):33–49.
Koh WM, Bogich T, Siegel K, Jin J, Chong EY, Tan CY, et al. The epidemiology of hand, foot and mouth disease in Asia: A systematic review and analysis. Pediatr Infect Dis J 2016;35(10):e285–300.
Arvin ANNM. Varicella-Zoster Virus. Clin Microbiol Rev 1996;9(3):361–81.
Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA. Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis of Disease, and Latency. Neurol Clin 2008;26:675–97. DOI: 10.1016/j.ncl.2008.03.011.
Boven M Van, Kassteele J Van De, Korndewal MJ, Van CH, Kretzschmar M, Klis F Van Der, et al. Infectious reactivation of cytomegalovirus explaining age and sex-specific patterns of seroprevalence. PLOS Computational Biology S 2017;(26):1–18. DOI:10.1371/journal.pcbi.1005719.
Crough T, Khanna R, Crough T, Khanna R. Immunobiology of Human Cytomegalovirus: from Bench to Bedside Immunobiology of Human Cytomegalovirus: from Bench to Bedside. Clin Microbiol Rev 2009;22(1):76-98.
Staras SAS, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ. Seroprevalence of Cytomegalovirus Infection in the United States, 1988-1994. Clin Infect Dis 2006;43(9):1143–51. DOI:10.1086/508173.
Smith JS, Robinson NJ, Thomas CA, Elisa T, Elisa T. Age-specific prevalence of infection with herpes simplex virus types 2 and 1: A global review. J Infect Dis 2002;Oct 15;186 Suppl 1:S3-28.
Doi Y, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Arima H, et al. Seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in Japan. J Epidemiol 2009;19(2):56–62. DOI: 10.2188/jea.JE20080061.
Buxbaum S, Geers M, Gross G, Schöfer H, Rabenau HF, Doerr HW. Epidemiology of herpes simplex virus types 1 and 2 in Germany: What has changed? Med Microbiol Immunol. 2003;192(3):177–81.
Schillinger JA, Xu F, Sternberg MR, Armstrong GL, Lee FK, Nahmias AJ, et al. National seroprevalence and trends in herpes simplex virus type 1 in the United States, 1976-1994. Sex Transm Dis. 2004;31(12):753–60.
Jatmiko AC, Nurharini F, Dewi DK, Murtiastutik D. Penderita Herpes Genitalis di Divisi Infeksi Menular Seksual Unit Rawat Jalan Kesehatan Kulit dan Kelamin RSUD Dr . Soetomo Surabaya Periode 2005 – 2007 (Genital Herpes in Division of Sexually Transmitted Infection–Outpatient Clinic Dr . Soetomo. 2007;(318):2005–10.
Fatahzadeh M, Schwartz RA. Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management. J Am Acad Dermatol 2007;57(5):737–63.
Mendoza JH De, Marin- B, Stock C, Guille F, Aguinaga-ontoso I, Kra A. Risk factors of herpes simplex type 1 (HSV-1) infection and lifestyle factors associated with HSV-1 manifestations. Eur J Epidemiol. 2001;17(9):885-90.
Glaser R, Kiecolt-Glaser JK. Chronic stress modulates the virus-specific immune response to latent herpes simplex virus type 1. Ann Behav Med. 1997;19(2):78–82.
Glaser R, Kiecolt-Glaser JK, Speicher CE, Holliday JE. Stress, loneliness, and changes in herpesvirus latency. J Behav Med 1985;8(3):249–60.
Dalkvist J, Wahlin TBR, Bartsch E, Forsbeck M. Herpes simplex and mood: A prospective study. Psychosom Med 1995;57(2):127–37.
Logan HL, Lutgendorf S, Hartwig A, Lilly J. Editors: Jed Jacobson and Margot Van Dis Immune, stress , and mood markers related to recurrent oral herpes outbreaks. Pathology. 1998;86(1):48–54..
Hapsari D. Pengaruh lingkungan sehat, dan perilaku hidup sehat terhadap status kesehatan. Bul Penelit Kesehat 2009;40-49.
Olsson J, Kok E, Adolfsson R, Lövheim H, Elgh F. Herpes virus seroepidemiology in the adult Swedish population. Immun Ageing 2017;May 10:4–9. DOI: 10.1186/s12979-017-0093-4.
Mcquillan G, Ph D, Kruszon-moran D, Flagg EW, Ph D, Paulose-ram R, et al. Prevalence of Herpes Simplex Virus Type 1 and Type 2 in Persons Aged 14–49: United State, 2015–2016. NCHS Data Brief 2018;(304):1-8.
Stowe RP, Peek MK, Perez NA, Yetman DL, Cutchin MP, Goodwin JS. Herpesvirus reactivation and socioeconomic position: a community-based study. Epidemiol Community Health. 2010;Aug;64(8):666-71. DOI: 10.1136/jech.2008.078808.
Al-Turab M, Chehadeh W. Varicella infection in the Middle East: Prevalence, complications, and vaccination. J Res Med Sci 2018 Apr 26;23:19. DOI: 10.4103/jrms.JRMS_979_17.
DOI: https://doi.org/10.24198/pjdrs.v3i1.22180
Refbacks
- There are currently no refbacks.
Statistik Pengunjung
Padjadjaran Journal of Dental Researchers and Students dilisensikan di bawah Creative Commons Attribution 4.0 International License